INT103999

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.12
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
neurons 2
ACC 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 8 99.80 Very High Very High Very High
Spinal cord 67 99.64 Very High Very High Very High
Inflammation 44 99.36 Very High Very High Very High
long-term potentiation 2 95.88 Very High Very High Very High
c fibre 5 94.68 High High
nMDA receptor 81 93.40 High High
Dorsal horn neuron 10 92.40 High High
Lasting pain 14 88.76 High High
Hyperalgesia 23 88.04 High High
allodynia 24 87.36 High High
Disease Link Frequency Relevance Heat
Nociception 43 99.74 Very High Very High Very High
INFLAMMATION 41 99.36 Very High Very High Very High
Targeted Disruption 3 91.76 High High
Pain 46 88.76 High High
Hyperalgesia 45 88.04 High High
Neuropathic Pain 38 87.36 High High
Inflammatory Pain 8 80.60 Quite High
Arthritis 15 66.64 Quite High
Congenital Anomalies 1 25.52 Quite Low
Frailty 5 20.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we used a relatively long lasting nociceptive stimulus to evaluate NR1 and NR2 subunit phosphorylation and protein expression.
Positive_regulation (evaluate) of Phosphorylation (phosphorylation) of NR2 associated with nociception
1) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.83 Pain Relevance 0.76
Importantly, BD1047 (30 nmol) administered intrathecally during the induction, but not the maintenance phase, blocked the CCI-induced increase in N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor subunit 1
2) Confidence 0.33 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.05 Pain Relevance 0
Indeed, EphB2 activation of Src by phosphorylation in cultured hippocampal and cortical neurons could induce NR2A phosphorylation (Grunwald et al., 2001).
Positive_regulation (induce) of Phosphorylation (phosphorylation) of NR2A in neurons
3) Confidence 0.27 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.15 Pain Relevance 0.33
Compared with naive rats, there was a rapid and prolonged increase in tyrosine phosphorylation of the NR2B, but not NR2A, subunit after inflammation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2A associated with inflammation
4) Confidence 0.25 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 0.98 Pain Relevance 0.95
Hindpaw inflammation increased the expression of NR2B, but not NR1 or NR2A, in the ACC [32] and increased tyrosine phosphorylation of NR2B, but not NR2A, in the spinal cord [34,35] but not ACC [32].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of NR2A in ACC associated with inflammation, anterior cingulate cortex and spinal cord
5) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2679723 Disease Relevance 1.11 Pain Relevance 1.91

General Comments

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