INT104000

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Context Info
Confidence 0.82
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 73
Total Number 114
Disease Relevance 48.34
Pain Relevance 93.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 22
dorsal horn 16
spinal 7
paw 5
descending colon 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2139 100.00 Very High Very High Very High
nMDA receptor 1721 100.00 Very High Very High Very High
Inflammation 670 100.00 Very High Very High Very High
Neuropathic pain 456 100.00 Very High Very High Very High
Thermal hyperalgesia 810 99.90 Very High Very High Very High
spinal dorsal horn 385 99.84 Very High Very High Very High
Eae 364 99.84 Very High Very High Very High
Dorsal horn 873 99.80 Very High Very High Very High
long-term potentiation 294 99.72 Very High Very High Very High
Ultiva 2310 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1131 100.00 Very High Very High Very High
INFLAMMATION 642 100.00 Very High Very High Very High
Hyperalgesia 2990 99.90 Very High Very High Very High
Inflammatory Pain 256 99.84 Very High Very High Very High
Pain 894 99.28 Very High Very High Very High
Post Operative Pain 211 99.26 Very High Very High Very High
Nociception 921 99.06 Very High Very High Very High
Frailty 63 98.28 Very High Very High Very High
Stress Incontinence 18 98.08 Very High Very High Very High
Complex Regional Pain Syndromes 6 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, pretreated ketamine decreased the higher level of NR2B tyrosine phosphorylation in spinal dorsal horn caused by intraoperative infusion of remifentanil (P < 0.05).


Phosphorylation (phosphorylation) of NR2B in spinal associated with ketamine, spinal dorsal horn and ultiva
1) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.14 Pain Relevance 0.96
The expression of NR2B tyrosine phosphorylation in rats receiving intraoperative remifentanil infusion was significantly upregulated when compared with rats receiving intraoperative saline infusion (P < 0.01).
Phosphorylation (phosphorylation) of NR2B associated with ultiva
2) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.22 Pain Relevance 1.07
Immunocytochemical localization and expression of NR2B phosphorylation at Tyr-1472 in spinal cord
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with spinal cord
3) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.57 Pain Relevance 0.96
So the activation of NMDARs positively correlates with phosphorylation of NR2B at Y1472 may be a component of underlying mechanisms of hyperalgesia induced by remifentanil.
Phosphorylation (phosphorylation) of NR2B associated with hyperalgesia and ultiva
4) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.76 Pain Relevance 1.60
These studies suggested an implication of tyrosine phosphorylation of NR2B in the enhancement of synaptic efficacy and thus the development of central sensitization.
Phosphorylation (phosphorylation) of NR2B associated with central sensitization
5) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.47 Pain Relevance 1.26
The second finding is that pretreatment with ketamine, via inhibiting tyrosine phosphorylation of NR2B in superficial spinal cord of rats, attenuated exaggerated hyperalgesia induced by remifentanil.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with hyperalgesia, ketamine, ultiva and spinal cord
6) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.77 Pain Relevance 1.63
To localize and assess the expression of NR2B phosphorylation at Tyr-1472 in the spinal cord during the maintenance of hyperalgesia induced by remifentanil, immunohistochemical studies were performed.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with hyperalgesia, ultiva and spinal cord
7) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.56 Pain Relevance 0.98
When compared with rats receiving sevoflurane and saline in the absence of surgery, the right hind paw plantar incision increased the level of NR2B tyrosine phosphorylation in the spinal dorsal cord (P < 0.01).
Phosphorylation (phosphorylation) of NR2B in spinal
8) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.20 Pain Relevance 1.04
This hypothesis is supported by immunohistochemical and westernblotting experiments in our study showing that remifentanil significantly increased the expression of tyrosine phosphorylation of NR2B in the lamina I-II of the L4-L5 spinal cord.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with ultiva and spinal cord
9) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.76 Pain Relevance 1.64
Our study reports for the first time in an vivo model of hyperalgesia induced by remifentanil that tyrosine phosphorylation of NR2B at Tyr1472 in spinal dorsal horn plays a key role in hyperalgesia induced by remifentanil.
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with hyperalgesia, spinal dorsal horn and ultiva
10) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.77 Pain Relevance 1.82
However, there have been no reports on whether tyrosine phosphorylation of NR2B is associated with the postoperative hyperalgesia induced by remifentanil.
Phosphorylation (phosphorylation) of NR2B associated with hyperalgesia and ultiva
11) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.41 Pain Relevance 1.25
It has been reported that tyrosine phosphorylation of the NR2B at Tyr1472 in the spinal dorsal horn contribute to the development of hyperalgesia in inflammation pain model, as well as neuropathic pain model [30,33].
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with pain, hyperalgesia, inflammation, spinal dorsal horn and neuropathic pain
12) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.80 Pain Relevance 1.20
The expression of NR2B tyrosine phosphorylation in the superficial dorsal horn of the group I, K, R, K+R was increased when compared to group C (P < 0.01).
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with dorsal horn
13) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.31 Pain Relevance 1.09
Correlated with the antihyperalgesic and antiallodynic effects of ketamine, in the present study immunocytochemical and western blotting experiment revealed pretreatment with ketamine 10 mg/kg reduced the higher level of NR2B tyrosine phosphorylation in spinal dorsal horn caused by remifentanil.
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with antihyperalgesic, ketamine, spinal dorsal horn, ultiva and antiallodynic
14) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.61 Pain Relevance 1.65
The expression of NR2B tyrosine phosphorylation in the superficial dorsal horn was weak in rats receiving sevoflurane and saline without surgery.
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with dorsal horn
15) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.38 Pain Relevance 1.08
Intraoperative infusion of remifentanil significantly enhanced the expression of NR2B tyrosine phosphorylation in the superficial dorsal horn of spinal cord(P < 0.05).
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with dorsal horn, ultiva and spinal cord
16) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.24 Pain Relevance 1.10
For each rat, the mean optical density of NR2B tyrosine phosphorylation was obtained by averaging the values from six sections.


Phosphorylation (phosphorylation) of NR2B
17) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0 Pain Relevance 0.18
Conversely, pretreatment of ketamine decreased the higher level of NR2B tyrosine phosphorylation in spinal dorsal horn caused by remifentanil (P < 0.01) (Figure 5).


Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with ketamine, spinal dorsal horn and ultiva
18) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.36 Pain Relevance 1.27
The first one is that hyperalgesia induced by remifentanil in a rat model of postoperative pain associated with an enhancement of tyrosine phosphorylation of NR2B in superficial spinal cord.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with hyperalgesia, perioperative pain, ultiva and spinal cord
19) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.67 Pain Relevance 1.53
To quantificate the expression of NR2B phosphorylation at Tyr-1472 in the dorsal horn during the maintenance of hyperalgesia induced by remifentanil, western blot studies were performed.
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with hyperalgesia, dorsal horn and ultiva
20) Confidence 0.82 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.15 Pain Relevance 0.97

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