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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.92 Very High Very High Very High
Glutamate 8 94.00 High High
Pain 6 93.40 High High
Lasting pain 1 87.68 High High
agonist 2 85.84 High High
sNRI 1 85.12 High High
depression 4 82.96 Quite High
Analgesic 2 75.00 Quite High
Fibrositis 2 75.00 Quite High
central sensitization 2 60.00 Quite High
Disease Link Frequency Relevance Heat
Injury 2 95.08 Very High Very High Very High
Pain 7 93.40 High High
Death 2 93.40 High High
Fibromyalgia 10 93.28 High High
Congenital Anomalies 4 84.16 Quite High
Depression 4 82.96 Quite High
Schizophrenia 13 66.28 Quite High
Somatoform Disorder 72 50.00 Quite Low
Obsessive-compulsive Disorder 10 50.00 Quite Low
Cerebral Toxoplasmosis 1 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examples of these include the use of CCKB antagonists to block on-cell activation or of nitric oxide synthetase antagonists to block the downstream mediators of NMDA activation.
Negative_regulation (block) of Positive_regulation (activation) of NMDA associated with antagonist
1) Confidence 0.15 Published 2002 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 12122916 Disease Relevance 1.24 Pain Relevance 0.83
Activation of the NMDAR as indicated by calcium influx was not inhibited, suggesting that clarithromycin (and the other macrolides studied) inhibited a downstream aspect of the NMDAR signal transduction (NMDAR-ST) cascade.
Negative_regulation (inhibited) of Positive_regulation (Activation) of NMDAR
2) Confidence 0.04 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2825652 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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