INT104013

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 2.36
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal cord 10
spinal 6
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 31 99.12 Very High Very High Very High
intrathecal 15 98.78 Very High Very High Very High
Morphine 36 98.24 Very High Very High Very High
Kinase C 17 98.08 Very High Very High Very High
tolerance 24 97.20 Very High Very High Very High
Inflammation 40 95.16 Very High Very High Very High
Hyperalgesia 15 89.52 High High
Inflammatory stimuli 5 85.96 High High
Analgesic 3 83.84 Quite High
spinal dorsal horn 5 82.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 95.16 Very High Very High Very High
Hyperalgesia 20 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal treatment with the antisense, but not the missense, in rats decreased expression of spinal protein kinase Calpha mRNA and protein, as revealed by real-time quantitative reverse transcription-polymerase chain reaction and western blots.
Negative_regulation (decreased) of Gene_expression (expression) of protein kinase in spinal associated with intrathecal
1) Confidence 0.31 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.63
These results demonstrate that selective reduction in the expression of the spinal protein kinase Calpha isozyme followed by a decrease of local protein kinase C-mediated phosphorylation will reverse spinal morphine infusion-induced tolerance.
Negative_regulation (reduction) of Gene_expression (expression) of protein kinase in spinal associated with kinase c, tolerance and morphine
2) Confidence 0.31 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.51
Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance.
Negative_regulation (Inhibition) of Gene_expression (expression) of protein kinase in spinal associated with tolerance and morphine
3) Confidence 0.31 Published 2002 Journal Neuroscience Section Title Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.36
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
4) Confidence 0.22 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.67
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
5) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.50 Pain Relevance 0.70
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
6) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
7) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Negative_regulation (decreased) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
8) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.51 Pain Relevance 0.70

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