INT104014

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.59
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
Morphine 12 99.16 Very High Very High Very High
tolerance 8 98.12 Very High Very High Very High
antagonist 4 96.32 Very High Very High Very High
Spinal cord 2 94.84 High High
palliative 1 94.20 High High
intrathecal 5 78.96 Quite High
adenocard 3 77.76 Quite High
opiate 1 71.20 Quite High
Analgesic 1 65.24 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 5 84.20 Quite High
Disease 5 75.12 Quite High
Dyskinesias 2 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that selective reduction in the expression of the spinal protein kinase Calpha isozyme followed by a decrease of local protein kinase C-mediated phosphorylation will reverse spinal morphine infusion-induced tolerance.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of protein kinase in spinal associated with kinase c, tolerance and morphine
1) Confidence 0.23 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.40
In hemiparkinsonian rats, KW6002 reversed the intermittent L-dopa treatment-induced, protein kinase A-mediated hyperphosphorylation of striatal alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid receptor GluR1 S845 residues and the concomitant shortening in motor response duration.
Negative_regulation (reversed) of Phosphorylation (hyperphosphorylation) of protein kinase
2) Confidence 0.09 Published 2003 Journal Neurology Section Abstract Doc Link 14663022 Disease Relevance 0.59 Pain Relevance 0.32

General Comments

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