INT104031

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 13.48
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ENPEP) peptidase activity (ENPEP) cell-cell signaling (ENPEP)
Anatomy Link Frequency
plasma 2
osteoblasts 2
platelet 1
ENPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 39 99.64 Very High Very High Very High
Fibrositis 141 96.28 Very High Very High Very High
allodynia 3 85.68 High High
Pain 32 84.20 Quite High
Restless leg syndrome 6 82.32 Quite High
backache 3 81.40 Quite High
headache 17 80.44 Quite High
Myofascial pain syndrome 3 79.72 Quite High
spastic colon 9 73.64 Quite High
depression 6 72.60 Quite High
Disease Link Frequency Relevance Heat
Dengue 832 99.84 Very High Very High Very High
Flavivirus Infection 640 99.84 Very High Very High Very High
Infection 308 99.22 Very High Very High Very High
Disease 165 98.80 Very High Very High Very High
Emergencies 21 98.80 Very High Very High Very High
Fibromyalgia 141 96.28 Very High Very High Very High
Neurodegenerative Disease 2 93.12 High High
Thrombocytopenia 64 89.76 High High
Pharyngitis 9 89.68 High High
Constipation 6 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 2007 APA resolution [12] reaffirmed the APA's commitment to a casebook and commentary, this time in the hands of the Ethics Committee.
Regulation (reaffirmed) of APA
1) Confidence 0.33 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2248202 Disease Relevance 0.14 Pain Relevance 0
Most consequential, though, is that the APA Ethics Committee did officially approve the report, calling it, without a single alteration, consistent with the APA Code of Ethics.
Regulation (approve) of APA
2) Confidence 0.33 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2248202 Disease Relevance 0.15 Pain Relevance 0
The 2007 APA resolution [12] reaffirmed the APA's commitment to a casebook and commentary, this time in the hands of the Ethics Committee.
Regulation (reaffirmed) of APA
3) Confidence 0.33 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2248202 Disease Relevance 0.19 Pain Relevance 0
APA levels were determined on serum samples by an indirect ELISA kit that detects IgG APA.
Spec (determined) Regulation (determined) of APA
4) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212586 Disease Relevance 0.93 Pain Relevance 0.55
APA levels were determined on serum samples by an indirect ELISA kit that detects IgG APA (Corgenix, Westminster, CO, USA), according to the manufacturer's instructions.
Spec (determined) Regulation (determined) of APA
5) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 1.83 Pain Relevance 0.76
APA rules and regulations on such task forces require "emergency" reports to be ratified by the Council of Representatives at the next Council meeting.
Regulation (regulations) of APA associated with emergencies
6) Confidence 0.20 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2248202 Disease Relevance 0.24 Pain Relevance 0
The effect of these drugs or of the addition of LTB(4) on alkaline phosphatase (AP) activity and osteocalcin release by OA and normal osteoblasts was determined.
Regulation (effect) of AP in osteoblasts
7) Confidence 0.18 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.09 Pain Relevance 0
A significant correlation was found, however, between APA levels and IL-1 values within the subset of patients with positive APA (P = 0.0072; Figure 2).
Regulation (values) of APA
8) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212586 Disease Relevance 0.94 Pain Relevance 0.38
Regardless of the differently worded position statements of the APA and A?
Regulation (Regardless) of APA
9) Confidence 0.14 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2561033 Disease Relevance 0 Pain Relevance 0
Selective effects of licofelone on AP and osteocalcin occur via its role on LTB(4) production.
Regulation (effects) of AP
10) Confidence 0.07 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
In normal osteoblasts, LTB(4) dose-dependently stimulated osteocalcin, whereas it failed to influence AP.
Neg (failed) Regulation (influence) of AP in osteoblasts
11) Confidence 0.07 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
Recent reports suggest that the puromycin sensitive aminopeptidase (PSA, EC 3.4.11.14) may regulate Tau levels in vivo [11], and is able to hydrolyze Tau in vitro [12].
Regulation (sensitive) of aminopeptidase
12) Confidence 0.05 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.33 Pain Relevance 0
Overall, the majority of the data presented here point to an association between the improper modulation of AP regulatory proteins and increased dengue severity.
Regulation (modulation) of AP associated with dengue
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.81 Pain Relevance 0
The complement factors of the CP that we examined here did not show any direct correlation with platelet levels; however, factor H did show strong correlation, supporting our conclusion that the lack of AP regulation is one of the mechanisms contributing to complement activation and disease severity.
Regulation (regulation) of AP in platelet associated with disease
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.89 Pain Relevance 0
Taken together, these data suggests that AP regulatory proteins such as factor H and factor D, as well as their substrates, are potential therapeutic targets to prevent the onset of DHF.



Regulation (targets) of AP associated with flavivirus infection
15) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.70 Pain Relevance 0
The lack of proper regulation of the AP convertase may be responsible for the increased complement activation that has been observed in DHF patients (Figure 6; Table 3).
Regulation (regulation) of AP associated with flavivirus infection
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.04 Pain Relevance 0
These results further support our conclusion that abnormal modulation of AP regulatory proteins is a significant factor contributing to dengue severity.


Regulation (modulation) of AP associated with dengue
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.42 Pain Relevance 0
The increased log-ratios in concentration between these factors in plasma samples from patients with acute dengue infection clearly pointed to an increase in the regulation of the AP in DF patients and a reduced regulation of the AP in DHF patients when compared to healthy controls.
Regulation (regulation) of AP in plasma associated with flavivirus infection, dengue and infection
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.03 Pain Relevance 0
Although factor D appears to play a role in determining dengue severity, factor H is also widely regarded as one of the most important regulator of the AP.
Regulation (regulator) of AP associated with dengue
19) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.71 Pain Relevance 0
The increased log-ratios in concentration between these factors in plasma samples from patients with acute dengue infection clearly pointed to an increase in the regulation of the AP in DF patients and a reduced regulation of the AP in DHF patients when compared to healthy controls.
Regulation (regulation) of AP in plasma associated with flavivirus infection, dengue and infection
20) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.05 Pain Relevance 0

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