INT104039

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 8.34
Pain Relevance 10.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) response to stress (Crhr1)
signal transducer activity (Crhr1)
Anatomy Link Frequency
neurons 2
NAc 1
BLA 1
body 1
ventral 1
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 20 100.00 Very High Very High Very High
amygdala 779 99.92 Very High Very High Very High
gABA 170 99.90 Very High Very High Very High
Dynorphin 441 99.68 Very High Very High Very High
Dopamine 27 99.54 Very High Very High Very High
Kappa opioid receptor 450 99.28 Very High Very High Very High
Ventral tegmentum 18 98.92 Very High Very High Very High
cocaine 14 98.84 Very High Very High Very High
opiate 7 98.48 Very High Very High Very High
GABAergic 112 98.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 499 99.48 Very High Very High Very High
Targeted Disruption 168 98.54 Very High Very High Very High
Aggression 111 98.36 Very High Very High Very High
Alcohol Addiction 56 98.04 Very High Very High Very High
Stress 457 96.68 Very High Very High Very High
Recurrence 16 92.24 High High
Depression 40 85.52 High High
Adrenocortical Insufficiency 1 67.36 Quite High
Sprains And Strains 25 46.36 Quite Low
Drug Dependence 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If future work demonstrates a consistent deficit in aggression in CRFR1-/- mice, this would be consistent with the idea that a certain level of activation of CRFR1 is necessary for normal maternal defense.
Positive_regulation (activation) of CRFR1 associated with aggression
1) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 1.27 Pain Relevance 0.15
Increasing central CRF levels (via icv injections) (which would presumably increase activation of CRFR1) decreases maternal responding in maternally sensitized virgin rats [6].
Positive_regulation (activation) of CRFR1
2) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.46 Pain Relevance 0.08
These data illustrate that CRF1R and CRF2R activation can initiate distinct dynorphin/KOR-dependent behaviors with CRF1R selectively initiating dynorphin-dependent anxiety-like responses and CRF2R initiating dynorphin-dependent place aversion.


Positive_regulation (activation) of CRF1R associated with dynorphin, anxiety disorder and kappa opioid receptor
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.44 Pain Relevance 0.66
mice is not clear, but it may be a consequence of the rewarding effects of dopamine release caused by CRF activation of CRF1-R expressing neurons in the ventral tegmental area [5], [35].
Positive_regulation (activation) of CRF1-R in ventral associated with ventral tegmentum and dopamine
4) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.41 Pain Relevance 0.59
The anxiogenic-like effects of CRF and stressin 1 suggest that CRF1-R receptor activation induces dynorphin release in the basolateral amygdala (BLA), a brain region regarded as necessary for anxiety-like behaviors [36].
Positive_regulation (activation) of CRF1-R in BLA associated with dynorphin, anxiety disorder and amygdala
5) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.38 Pain Relevance 0.72
However, CRF2-R knockout animals did not develop CRF conditioned place aversion, suggesting that CRF1-R activation may mediate anxiety and CRF2-R may encode aversion.
Positive_regulation (activation) of CRF1-R associated with targeted disruption and anxiety disorder
6) Confidence 0.52 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.80 Pain Relevance 0.86
These results were surprising given that CRF1-R activation contributes to the aversion evident during drug withdrawal and during reinstatement to drug seeking [3], [6].
Positive_regulation (activation) of CRF1-R associated with withdrawal
7) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.42 Pain Relevance 0.27
ACTH treatment increased epinephrine and PNMT mRNA level in CRHR1 null mice but failed to restore them to normal levels.
Neg (failed) Positive_regulation (increased) of CRHR1
8) Confidence 0.50 Published 2002 Journal Mol. Psychiatry Section Abstract Doc Link 12399950 Disease Relevance 0.13 Pain Relevance 0.23
Mice were sacrificed 30 min after the last injection and mRNAs for ppDyn and preproenkephalin (ppEnk) in the CPu and nucleus accumbens (NAc), and for type I corticotropin-releasing hormone receptor (CRH(1) receptor) and pro-opiomelanocortin (POMC) in the hypothalamus and pituitary, were measured by solution hybridization RNase protection assays.
Positive_regulation (sacrificed) of I corticotropin-releasing hormone receptor in NAc associated with nucleus accumbens
9) Confidence 0.44 Published 2002 Journal Synapse Section Abstract Doc Link 12125043 Disease Relevance 0.25 Pain Relevance 0.88
Using pharmacological and genetic approaches, we found that the anxiogenic-like effects of Corticotropin Releasing Factor (CRF) were triggered by CRF1-R activation of the dynorphin/kappa opioid receptor (KOR) system.
Positive_regulation (activation) of CRF1-R associated with dynorphin and kappa opioid receptor
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.38 Pain Relevance 0.70
This body of prior work, combined with the present study, reveal a connection between CRF1-R dependent activation and the BLA dynorphin/KOR system, and suggest that neurobiological mechanisms for stress-induced anxiety and reinstatement of drug seeking may be mediated via a common CRF-induced dynorphin/KOR dependent pathway.
Positive_regulation (activation) of CRF1-R in body associated with stress, dynorphin, anxiety disorder, kappa opioid receptor and amygdala
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.92 Pain Relevance 0.57
In finding that KORp-ir was not increased in CRF1-R (?
Neg (not) Positive_regulation (increased) of CRF1-R
12) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.55 Pain Relevance 0.77
Together with anatomical and behavioral results revealing a role for CRF1-R activity in the BLA, a role for these neurons is implicated in modulating anxiety responses and aversive memories including the modulation of hedonic state [4], [50].
Positive_regulation (role) of CRF1-R in neurons associated with anxiety disorder and amygdala
13) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.41 Pain Relevance 0.76
CRF1 is a GPCR that is positively linked to the activation of AC and other second messenger systems such as IP3 and PKC (Bajo et al., 2008).
Positive_regulation (activation) of CRF1
14) Confidence 0.31 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.38 Pain Relevance 0.33
Disruption of CRF1 activation reduces negative affective states of opiate and alcohol withdrawal (Contarino and Papaleo, 2005; Gilpin et al., 2008), and pharmacological inhibition of CRF1 suppresses stress-mediated alcohol relapse in rats genetically selected for high alcohol preference (Valdez and Koob, 2004; Hansson et al., 2006).
Positive_regulation (activation) of CRF1 associated with stress, opiate, withdrawal, recurrence and alcohol
15) Confidence 0.31 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.44 Pain Relevance 0.50
Previous studies indicated that in the CeA, ethanol acts through activation of CRF1 and its signaling pathways.
Positive_regulation (activation) of CRF1 associated with amygdala
16) Confidence 0.31 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.37 Pain Relevance 0.56
Previously, we found that both ethanol and corticotropin releasing factor (CRF) increase GABAergic transmission in mouse and rat CeA neurons, in part by enhancing the release of GABA via activation of presynaptic CRF1 receptors.
Positive_regulation (activation) of CRF1 in neurons associated with gaba, gabaergic and amygdala
17) Confidence 0.22 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.52
The CRF1 receptor is a G-protein-coupled receptor (GPCR) that is predominantly linked to the activation of adenylyl cyclase (AC), and also other second messenger systems such as inositol trisphosphate and protein kinase C (PKC; Grammatopoulos et al., 2001; Blank et al., 2003).
Positive_regulation (linked) of CRF1 receptor associated with kinase c
18) Confidence 0.22 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.18 Pain Relevance 0.46
In addition, eight splice variants of CRHR1 (a-h isoforms) (Pisarchik and Slominski, 2001) and three splice variants of CRHR2 (?
Positive_regulation (variants) of CRHR1
19) Confidence 0.21 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.08 Pain Relevance 0.43
Recent data suggest that CRF1 activation increases the enzymatic activity of AC7 (Antoni et al., 2003; Pronko et al., 2010).
Positive_regulation (activation) of CRF1
20) Confidence 0.21 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.49

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