INT104040

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr2) Golgi apparatus (Crhr2) endoplasmic reticulum (Crhr2)
plasma membrane (Crhr2) signal transducer activity (Crhr2)
Anatomy Link Frequency
striatum 1
Crhr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 14 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
opioid receptor 1 97.20 Very High Very High Very High
dopamine receptor 1 94.16 High High
mu opioid receptor 10 85.76 High High
Nucleus accumbens 4 68.80 Quite High
Neuropeptide 2 30.24 Quite Low
antagonist 7 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 23 99.32 Very High Very High Very High
Targeted Disruption 17 96.56 Very High Very High Very High
Lung Cancer 4 89.68 High High
Stress 5 89.44 High High
Aggression 55 86.28 High High
Sprains And Strains 8 43.12 Quite Low
Depression 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice.
Regulation (Effects) of corticotropin-releasing hormone receptor mRNA in striatum associated with targeted disruption, enkephalin, opioid receptor and cocaine
1) Confidence 0.36 Published 2002 Journal Synapse Section Title Doc Link 12125043 Disease Relevance 0.27 Pain Relevance 0.81
Levels of CRFR2 in these mice was not altered.
Neg (not) Regulation (altered) of CRFR2
2) Confidence 0.22 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 1.03 Pain Relevance 0

General Comments

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