INT104045

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 65
Total Number 68
Disease Relevance 51.32
Pain Relevance 16.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
T cell 5
CANS 2
macrophage 1
left-right 1
Th1 cells 1
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1038 100.00 Very High Very High Very High
cINOD 22 100.00 Very High Very High Very High
Versed 3 100.00 Very High Very High Very High
Multiple sclerosis 382 99.84 Very High Very High Very High
Neuritis 53 99.76 Very High Very High Very High
Opioid 7 99.60 Very High Very High Very High
Inflammation 826 99.40 Very High Very High Very High
Inflammatory response 62 99.30 Very High Very High Very High
chemokine 348 99.28 Very High Very High Very High
epidural 2 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 887 100.00 Very High Very High Very High
Demyelinating Disease 278 99.84 Very High Very High Very High
Disease 909 99.78 Very High Very High Very High
Experimental Autoimmune Neuritis 32 99.76 Very High Very High Very High
Immunization 285 99.72 Very High Very High Very High
Burns 128 99.58 Very High Very High Very High
Mycobacterial Infection 165 99.52 Very High Very High Very High
Influenza Virus Infection 93 99.44 Very High Very High Very High
Cold Sores 422 99.28 Very High Very High Very High
Neuromyelitis Optica 36 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of the nonsteroidal anti-inflammatory drug indomethacin on Th1 and Th2 immune responses in mice.
Regulation (Effect) of Th1 associated with inflammation and cinod
1) Confidence 0.35 Published 2003 Journal J Pharm Sci Section Title Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.35
The present study was undertaken to study the effect of the nonsteroidal anti-inflammatory drug indomethacin on Th1 and Th2 immune responses.
Regulation (effect) of Th1 associated with inflammation and cinod
2) Confidence 0.35 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.17 Pain Relevance 0.17
Indomethacin inhibited both Th1 and Th2 responses, although the nonsteroidal anti-inflammatory drug suppressed the former more effectively than the latter.
Regulation (responses) of Th1 associated with inflammation and cinod
3) Confidence 0.35 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.37
This stress hormone has been reported to shift the immune response from Th1 to Th2 by the down-regulation of Th1 cytokine expression.
Regulation (regulation) of Th1 associated with stress and cytokine
4) Confidence 0.35 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20408448 Disease Relevance 1.43 Pain Relevance 0.70
In repeated restimulations, reflecting a lack of clearance of the antigen and increased risk of immunopathology, regulation of Th1 may help to limit immunopathology, as we show in the chronic inflammation of the antigen-induced arthritis model by knockdown of twist1, but twist1-expressing Th1 cells are still capable of driving inflammation.
Regulation (regulation) of Th1 in Th1 cells associated with inflammation and arthritis
5) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.79 Pain Relevance 0.28
Therefore, our studies and other previous studies suggested that BECs are a promising target for intranasal Th1 modulator genes in the management of allergic pulmonary disease, and that intranasal administration is a safe, efficient and noninvasive mucosal route of treatment against allergic asthma [33].
Regulation (target) of Th1 associated with asthma, pulmonary disease and hypersensitivity
6) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 1.08 Pain Relevance 0.18
Many microbial products, including heat-killed bacteria and CpG motifs can up-regulate Th1 cytokines.
Regulation (regulate) of Th1 associated with cytokine
7) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.67 Pain Relevance 0.19
As Th1-promoting activity of CpG-ODN is controlled by IL-12[12], we measured the levels of IL-12 and found that production was elevated in the CpG-ODN WT group.
Regulation (controlled) of Th1
8) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.80 Pain Relevance 0.26
Ab treatment did not reveal an inhibitory effect on TH1 mediated airway neutrophilia and AHR.
Regulation (effect) of TH1
9) Confidence 0.26 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.70 Pain Relevance 0.22
Modulation of SOCS3 levels in T cells could be useful in regulating the Th1/Th2 balance for the treatment of autoimmune inflammatory diseases.


Regulation (regulating) of Th1 in T cells associated with inflammation and disease
10) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.87 Pain Relevance 0.31
Treatment with CD40 siRNA remarkably inhibited Th1 recall response, as evidenced by decreased IL-2 (Figure 2C), and IFN-?
Regulation (response) of Th1
11) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.26 Pain Relevance 0.21
A Th2 response was superimposed on the background Th1 response.
Regulation (response) of Th1
12) Confidence 0.25 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.27 Pain Relevance 0.17
It has been reported that elderly people, who face higher risk from influenza infection, have decreased IL-2 production, diminished cytotoxic T-lymphocyte (CTL) activity [46], [47], [48] and changes in T helper cell memory affecting the Th1 responses to influenza infection [49].
Regulation (affecting) of Th1 in cytotoxic T-lymphocyte associated with influenza virus infection
13) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.38 Pain Relevance 0
Systemic administration of recombinant pBTLA decreased the role of characteristic Th1 cytokines during HSV-1 infection.
Regulation (role) of Th1 associated with cold sores, infection and cytokine
14) Confidence 0.23 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.87 Pain Relevance 0.17
Cells cultured with IL-12p70 up-regulated the Th1-associated transcription factor, T-bet, and secreted IFN-?
Regulation (regulated) of Th1
15) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.46 Pain Relevance 0.10
While there are clearly some differences in human and murine systems, therapies for MS have nevertheless aimed to either reduce Th1 or Th17 responses or to increase Th2 responses.
Regulation (responses) of Th1 associated with multiple sclerosis
16) Confidence 0.22 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.42 Pain Relevance 0.67
Depending on the concept of balance shift, this review introduces [I] alteration of the balance between Th1(IFN-?)
Regulation (alteration) of Th1
17) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.96 Pain Relevance 0.33
Dysregulation of the Th1/Th2 balance can result in autoimmune diseases [143].
Regulation (Dysregulation) of Th1 associated with autoimmune disease
18) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.20 Pain Relevance 0.92
Since the underlying mechanisms by which this and other immunomodulatory effects occur have not been established, this report explores the in vitro modulation of Th1 and Th2 cytokine expression by these peptides.
Regulation (modulation) of Th1 associated with cytokine
19) Confidence 0.17 Published 2005 Journal Neuroimmunomodulation Section Abstract Doc Link 16557034 Disease Relevance 0.09 Pain Relevance 0.33
We found a clear reduction in Th1 response (IL-2 and IFN-?)
Regulation (response) of Th1
20) Confidence 0.16 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.79 Pain Relevance 0.25

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