INT104075

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Context Info
Confidence 0.09
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.36
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B4GALNT1) plasma membrane (B4GALNT1) carbohydrate metabolic process (B4GALNT1)
Anatomy Link Frequency
plaques 4
epithelial cell 2
B4GALNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 100.00 Very High Very High Very High
Kinase C 19 99.04 Very High Very High Very High
Abeta 10 98.34 Very High Very High Very High
cytokine 62 96.40 Very High Very High Very High
agonist 10 95.82 Very High Very High Very High
Inflammation 92 86.88 High High
Cannabinoid 4 85.04 High High
antagonist 2 81.76 Quite High
cannabis 1 78.76 Quite High
cINOD 8 76.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 11 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Atherosclerotic Plaque 10 99.62 Very High Very High Very High
Atherosclerosis 78 99.44 Very High Very High Very High
Apoptosis 8 99.24 Very High Very High Very High
Stress 46 98.36 Very High Very High Very High
Granuloma 4 97.92 Very High Very High Very High
Hypertension 77 97.30 Very High Very High Very High
INFLAMMATION 125 97.08 Very High Very High Very High
Disease 48 96.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.
Positive_regulation (inducible) of Gene_expression (expressions) of NO synthase
1) Confidence 0.09 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0
Recent studies show that amyloid beta (Abeta), a peptide extensively studied in Alzheimer's disease and that is cleaved from APP by beta- and gamma-secretase, and/or Abeta-like peptides are also present in human atherosclerotic plaques, in particular in activated, inducible nitric oxide synthase (iNOS) expressing perivascular macrophages that had phagocytized platelets.
Positive_regulation (inducible) of Gene_expression (expressing) of synthase in plaques associated with atherosclerotic plaque, alzheimer's dementia, disease and abeta
2) Confidence 0.03 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.38
Recent studies show that amyloid beta (Abeta), a peptide extensively studied in Alzheimer's disease and that is cleaved from APP by beta- and gamma-secretase, and/or Abeta-like peptides are also present in human atherosclerotic plaques, in particular in activated, inducible nitric oxide synthase (iNOS) expressing perivascular macrophages that had phagocytized platelets.
Positive_regulation (activated) of Gene_expression (expressing) of synthase in plaques associated with atherosclerotic plaque, alzheimer's dementia, disease and abeta
3) Confidence 0.03 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.38
The hypertension related organ damage was more completely prevented by zofenopril–HCTZ than by the enalapril–HCTZ combination and it was related to an activation of endothelial nitric oxide (NO) synthase expression and to a normalization of the oxidative stress components due to angiotensin II inhibition (Gagnon et al 2004).
Positive_regulation (activation) of Gene_expression (expression) of synthase associated with stress and hypertension
4) Confidence 0.01 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.74 Pain Relevance 0.04
PKC may have multiple adverse effects on vascular function, including the activation of superoxide-producing enzymes such as the nicotinamide adenine dinicleotide phosphate (NADPH) oxidase as well as increased expression of a dysfunctional, superoxide-producing, uncoupled endothelial nitric oxide synthase (NOS III).
Positive_regulation (activation) of Gene_expression (expression) of synthase associated with kinase c
5) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.15 Pain Relevance 0.24
PKC may have multiple adverse effects on vascular function, including the activation of superoxide-producing enzymes such as the nicotinamide adenine dinicleotide phosphate (NADPH) oxidase as well as increased expression of a dysfunctional, superoxide-producing, uncoupled endothelial nitric oxide synthase (NOS III).
Positive_regulation (increased) of Gene_expression (expression) of synthase associated with kinase c
6) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.05 Pain Relevance 0.23
Our results show that local administration of WIN 55,212-2, a CB(1)/CB(2) agonist, given daily or at time of implantation significantly decreased weight and neo-angiogenesis in granuloma tissue and inhibited nuclear factor-kappa B (NF-kappaB)/DNA binding that was associated with a reduced inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) messenger RNA (mRNA) and protein expression.
Positive_regulation (inducible) of Gene_expression (expression) of synthase associated with necrosis, cancer, agonist, cox2 and granuloma
7) Confidence 0.00 Published 2007 Journal J. Mol. Med. Section Abstract Doc Link 17447045 Disease Relevance 0.82 Pain Relevance 0.58
Expression of epithelial inducible nitric oxide synthase and NO production was reduced in a human trachea epithelial cell line where CFTR activity was blocked by the over-expression of the CFTR regulatory domain.
Positive_regulation (inducible) of Gene_expression (production) of synthase in epithelial cell
8) Confidence 0.00 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.37 Pain Relevance 0.22
IL-10 is expressed in advanced human atherosclerosis and is associated with low inducible nitric oxide synthase expression and low levels of apoptosis, again suggesting a protective role of this antiinflammatory cytokine [49].
Positive_regulation (inducible) of Gene_expression (expression) of synthase associated with inflammation, atherosclerosis, apoptosis and cytokine
9) Confidence 0.00 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.16 Pain Relevance 0.16

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