INT104120

Context Info Confidence 0.49 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.54

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1) cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)

Anatomy Link Frequency neurons 2 MAP2K1 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 10 99.98 dopamine receptor 2 72.44 gABA 3 69.04 Clonidine 1 60.48 agonist 1 58.96 Morphine 1 57.24 opioid receptor 1 56.48 antagonist 6 50.20 Opioid 1 49.76 Dopamine 1 33.60

Disease Link Frequency Relevance Heat Aids-related Complex 1 46.76 Alcohol Addiction 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, blockade of ERK 1/2 phosphorylation with the mitogen-activated protein kinase (MEK) 1/2 inhibitor SL327 blocked alcohol-induced c-Fos expression, suggesting that alcohol induces c-Fos in Edinger-Westphal neurons through activation of the MEK1/2-ERK1/2-Stat3 pathway.

Positive_regulation (induces) of Positive_regulation (activation) of MEK1 in neurons associated with alcohol

1) Confidence 0.49 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0 Pain Relevance 0.54

General Comments

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