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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1)
cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)
Anatomy Link Frequency
neurons 2
MAP2K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 10 99.98 Very High Very High Very High
dopamine receptor 2 72.44 Quite High
gABA 3 69.04 Quite High
Clonidine 1 60.48 Quite High
agonist 1 58.96 Quite High
Morphine 1 57.24 Quite High
opioid receptor 1 56.48 Quite High
antagonist 6 50.20 Quite High
Opioid 1 49.76 Quite Low
Dopamine 1 33.60 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 1 46.76 Quite Low
Alcohol Addiction 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, blockade of ERK 1/2 phosphorylation with the mitogen-activated protein kinase (MEK) 1/2 inhibitor SL327 blocked alcohol-induced c-Fos expression, suggesting that alcohol induces c-Fos in Edinger-Westphal neurons through activation of the MEK1/2-ERK1/2-Stat3 pathway.
Positive_regulation (induces) of Positive_regulation (activation) of MEK1 in neurons associated with alcohol
1) Confidence 0.49 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0 Pain Relevance 0.54

General Comments

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