INT104134

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2002
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.52
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6)
transmembrane transport (SLC22A6)
Anatomy Link Frequency
oocytes 1
SLC22A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 27 99.76 Very High Very High Very High
cINOD 23 99.76 Very High Very High Very High
diclofenac 1 89.60 High High
Paracetamol 1 87.92 High High
Disease Link Frequency Relevance Heat
Disease 2 95.36 Very High Very High Very High
INFLAMMATION 5 90.52 High High
Adverse Drug Reaction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.
hOAT1 Binding (interaction) of associated with methotrexate
1) Confidence 0.34 Published 2004 Journal Drug Metab. Pharmacokinet. Section Title Doc Link 15548848 Disease Relevance 0.17 Pain Relevance 0.60
In this study, we examined the drug interaction via hOAT1 and hOAT3, using Xenopus laevis oocytes. hOAT1 and hOAT3 mediated the methotrexate transport with low affinity (K(m) of 724.0 muM) and high affinity (K(m) of 17.2 muM), respectively.
hOAT1 Spec (examined) Binding (interaction) of in oocytes associated with methotrexate
2) Confidence 0.33 Published 2004 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 15548848 Disease Relevance 0.19 Pain Relevance 0.57
In addition, hOAT1, hOAT3, and hOAT4 are the sites of drug interactions between methotrexate and NSAIDs, probenecid, and penicillin G.
hOAT1 Binding (interactions) of associated with cinod and methotrexate
3) Confidence 0.08 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130730 Disease Relevance 0 Pain Relevance 0.48
By comparing the IC(50) values of NSAIDs for hOATs, it was found that hOAT1 and hOAT3 exhibited higher affinity interactions with NSAIDs than did hOAT2 and hOAT4.
hOAT1 Binding (interactions) of associated with cinod
4) Confidence 0.08 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388633 Disease Relevance 0.16 Pain Relevance 1.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox