INT104170

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.38
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 98.96 Very High Very High Very High
induced neuropathy 3 97.28 Very High Very High Very High
Sciatic nerve 6 95.88 Very High Very High Very High
Spinal cord 5 95.60 Very High Very High Very High
tetrodotoxin 3 86.92 High High
Action potential 3 79.40 Quite High
cerebral cortex 1 62.08 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 1 99.66 Very High Very High Very High
Hypoxia 15 98.68 Very High Very High Very High
Neuropathic Pain 3 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calpain inhibitors (10 microM calpain inhibitor I or 50 microM MDL 28,170) significantly reduced NF160 and NF200 breakdown/dephosphorylation, but did not improve electrophysiological recovery.
Phosphorylation (breakdown/dephosphorylation) of NF200
1) Confidence 0.34 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133577 Disease Relevance 0.37 Pain Relevance 0.11
Calpain inhibitors (10 microM calpain inhibitor I or 50 microM MDL 28,170) significantly reduced NF160 and NF200 breakdown/dephosphorylation, but did not improve electrophysiological recovery.
Phosphorylation (breakdown/dephosphorylation) of NF160
2) Confidence 0.34 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133577 Disease Relevance 0.38 Pain Relevance 0.11
CaMKII and PKC might mediate the HD neurotoxicity by altering the NF phosphorylation status and PRs.
Phosphorylation (phosphorylation) of NF associated with kinase c and drug induced neurotoxicity
3) Confidence 0.27 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.21 Pain Relevance 0.84
Non-phosphorylated NF200 appeared after reperfusion post-anoxia or OGD, and was also greatly reduced by zero-Ca(2+) or TTX.
Phosphorylation (phosphorylated) of NF200 associated with hypoxia
4) Confidence 0.23 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133577 Disease Relevance 0.42 Pain Relevance 0.13

General Comments

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