INT104183

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.16
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC2) ATPase activity (ABCC2) plasma membrane (ABCC2)
transmembrane transport (ABCC2)
Anatomy Link Frequency
MDCK 8
proximal 2
lung 2
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 11 98.96 Very High Very High Very High
cINOD 8 98.82 Very High Very High Very High
dexamethasone 2 97.84 Very High Very High Very High
Potency 1 89.20 High High
Inflammation 3 82.72 Quite High
diclofenac 1 54.40 Quite High
Opioid 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Lung Cancer 6 96.58 Very High Very High Very High
Cancer 2 91.56 High High
Disease 1 83.08 Quite High
INFLAMMATION 7 82.72 Quite High
Asthma 2 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DEX and HCT in the submicromolar concentration range caused a 2-fold induction of transcriptional activity at the MRP3 promoter construct, while MRP2 expression was not activated.
Neg (not) Positive_regulation (activated) of Gene_expression (expression) of MRP2
1) Confidence 0.68 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15979871 Disease Relevance 0.41 Pain Relevance 0.13
A549 cells (non-small-cell lung cancer cell line) were challenged with glucocorticoids (dexamethasone, hydrocortisone and prednisone) at physiologically and therapeutically relevant concentrations for 24h and changes in MRP2 and MRP3 expression were followed on four levels: promoter regulation (luciferase reporter constructs), mRNA level (semi-quantitative real-time PCR), protein level (Western blotting) and activity (drug resistance and cellular transport of the model substrate calcein).
Positive_regulation (changes) of Gene_expression (expression) of MRP2 in lung associated with lung cancer and dexamethasone
2) Confidence 0.49 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15979871 Disease Relevance 0.43 Pain Relevance 0.13
Here, we studied the effect of various NSAIDs on MTX transport in membrane vesicles isolated from cells overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP) 2/ABCC2 and MRP4/ABCC4.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ABCC2 in proximal associated with cinod and methotrexate
3) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.32 Pain Relevance 0.92
MDCK cells transfected with the human MDR1 gene (MDCK-MDR1), and MDCK cells transfected with human MRP2 gene (MDCK-MRP2).
Positive_regulation (transfected) of Gene_expression (transfected) of MRP2 in MDCK
4) Confidence 0.48 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134948 Disease Relevance 0 Pain Relevance 0
MDCK cells transfected with the human MDR1 gene (MDCK-MDR1), and MDCK cells transfected with human MRP2 gene (MDCK-MRP2).
Positive_regulation (transfected) of Gene_expression (transfected) of MRP2 in MDCK
5) Confidence 0.48 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134948 Disease Relevance 0 Pain Relevance 0
METHODS: The cellular permeation characteristics of AD were investigated using Caco-2 cells, Madin-Darby canine kidney wild-type II cells (MDCK-WT), MDCK cells transfected with the human MDR1 gene (MDCK-MDR1), and MDCK cells transfected with the human MRP2 gene (MDCK-MRP2).
Positive_regulation (transfected) of Gene_expression (transfected) of MRP2 in MDCK
6) Confidence 0.47 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134947 Disease Relevance 0 Pain Relevance 0
The cellular permeation characteristics of DADLE and its oxymethyl-modified prodrug 2 were measured by HPLC using Caco-2 cells, wild type Madin-Darby Canine Kidney cells (MDCK-WT), MDCK cells transfected with human MDR1 gene (MDCK-MDR1), and MDCK cells transfected with human MRP2 gene (MDCK-MRP2) grown onto microporous membranes.
Positive_regulation (transfected) of Gene_expression (transfected) of MRP2 in MDCK
7) Confidence 0.43 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134949 Disease Relevance 0 Pain Relevance 0

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