INT104185

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.64
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC2) ATPase activity (ABCC2) plasma membrane (ABCC2)
transmembrane transport (ABCC2)
Anatomy Link Frequency
plasma 1
hepatocytes 1
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 11 100.00 Very High Very High Very High
cINOD 7 100.00 Very High Very High Very High
Bile 3 99.10 Very High Very High Very High
Bioavailability 30 98.08 Very High Very High Very High
diclofenac 10 95.80 Very High Very High Very High
Cancer pain 1 94.08 High High
rheumatoid arthritis 1 92.44 High High
Perioperative pain 1 91.56 High High
Inflammation 2 88.96 High High
Analgesic 1 88.08 High High
Disease Link Frequency Relevance Heat
Breast Cancer 3 100.00 Very High Very High Very High
Cancer Pain 1 94.08 High High
Rheumatoid Arthritis 1 92.44 High High
Post Operative Pain 1 91.56 High High
INFLAMMATION 5 88.96 High High
Disease 1 45.72 Quite Low
Hepatotoxicity 3 41.96 Quite Low
Arrhythmia Under Development 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that loss of multidrug resistance protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ABCG2) in mice results in highly increased plasma levels of diclofenac acyl glucuronide, after both oral and intravenous administration.
Negative_regulation (loss) of ABCC2 in plasma associated with breast cancer and diclofenac
1) Confidence 0.57 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.60
The substrate activity of CD for MRP2 was determined by using cyclosporin A (CsA), a known MRP2 and P-gp inhibitor.
Negative_regulation (using) of MRP2
2) Confidence 0.41 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134948 Disease Relevance 0 Pain Relevance 0
Our data suggest that the inhibition by NSAIDs of renal MTX efflux via MRP2 and MRP4 is a potential new site and mechanism contributing to the overall interaction between these drugs.
Negative_regulation (inhibition) of MRP2 associated with cinod and methotrexate
3) Confidence 0.40 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.07 Pain Relevance 0.65
The substrate activity of AD for MRP2 was determined by using cyclosporin A, a known MRP2 and P-gp inhibitor.
Negative_regulation (using) of MRP2
4) Confidence 0.40 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134947 Disease Relevance 0 Pain Relevance 0
In conclusion, sulindac and metabolites are potent inhibitors of the uptake and biliary clearance of bile acids in rat and human hepatocytes and also inhibit substrates of rat breast cancer resistance protein, rat and human organic anion-transporting polypeptides, and human multidrug resistance-associated protein 2.
Negative_regulation (inhibit) of multidrug resistance-associated protein 2 in hepatocytes associated with bile and breast cancer
5) Confidence 0.37 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20430841 Disease Relevance 0.10 Pain Relevance 0.05
The efflux of the modified prodrug could be inhibited by GF120918 (an inhibitor for P-gp) and cyclosporin A (an inhibitor for P-gp and MRP2).
Negative_regulation (inhibitor) of MRP2
6) Confidence 0.37 Published 2002 Journal Pharm. Res. Section Body Doc Link 12134949 Disease Relevance 0 Pain Relevance 0
In fact, grapefruit juice has also shown inhibition of multidrug resistant protein 2 (MRP2), an efflux protein closely related to Pgp in terms of its expression and function [26].
Negative_regulation (inhibition) of MRP2
7) Confidence 0.03 Published 2007 Journal Nutr J Section Body Doc Link PMC2147024 Disease Relevance 0 Pain Relevance 0.20

General Comments

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