INT104207

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 25.80
Pain Relevance 7.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
osteoclast 14
osteoblasts 12
T cells 12
MC3T3-E1 6
macrophages 4
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 450 99.96 Very High Very High Very High
cytokine 439 99.88 Very High Very High Very High
Inflammation 603 99.50 Very High Very High Very High
Arthritis 421 98.88 Very High Very High Very High
chemokine 46 94.80 High High
Inflammatory marker 8 90.28 High High
antagonist 31 84.92 Quite High
Inflammatory mediators 40 83.92 Quite High
Pain 45 77.76 Quite High
metalloproteinase 29 71.44 Quite High
Disease Link Frequency Relevance Heat
Metastasis 24 100.00 Very High Very High Very High
Reprotox - General 1 13 100.00 Very High Very High Very High
Rheumatoid Arthritis 450 99.96 Very High Very High Very High
Atherosclerosis 186 99.92 Very High Very High Very High
Cancer 186 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 58 99.64 Very High Very High Very High
INFLAMMATION 639 99.50 Very High Very High Very High
Osteoporosis 381 99.42 Very High Very High Very High
Arthritis 488 98.88 Very High Very High Very High
Osteolysis 77 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The expressions of RANKL mRNA and protein in synovial cells were increased with compressive force.
Positive_regulation (increased) of Gene_expression (expressions) of RANKL mRNA in synovial cells
1) Confidence 0.69 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17321443 Disease Relevance 0.08 Pain Relevance 0
RANKL mRNA and RANKL protein expressions increased in both ST2 cells and MC3T3-E1 cells in a MIP-1alpha concentration-dependent manner.
Positive_regulation (increased) of Gene_expression (expressions) of RANKL mRNA in MC3T3-E1
2) Confidence 0.69 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.31 Pain Relevance 0.11
RANKL mRNA expression began to increase at 1 h after the addition of MIP-1alpha; the increase became remarkable at 2 h, and continuous expression was observed subsequently.
Positive_regulation (increase) of Gene_expression (expression) of RANKL mRNA
3) Confidence 0.69 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.30 Pain Relevance 0.11
When SB203580, a p38MAPK inhibitor, was added, RANKL mRNA and RANKL protein expression were increased in these cells.
Positive_regulation (increased) of Gene_expression (expression) of RANKL protein
4) Confidence 0.69 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.46 Pain Relevance 0.04
Both ST2 and MC3T3-E1 cells showed similar levels of increased RANKL protein expression at 1, 2, and 3 days after the addition of MIP-1alpha.
Positive_regulation (increased) of Gene_expression (expression) of RANKL protein in MC3T3-E1
5) Confidence 0.69 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.27 Pain Relevance 0.10
This, in turn, upregulates levels of expression of RANKL and interleukin-6, which further exacerbates bone destruction and increases tumor burden [30].
Positive_regulation (upregulates) of Gene_expression (expression) of RANKL associated with cancer
6) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.06 Pain Relevance 0.22
Moreover, transfer of the OPG gene into ARH-77 cells reduces the development of osteolytic bony lesions when these cells are injected into SCID mice, compared to mice injected with either unmodified ARH-77 cells or ARH-77 cells transduced with the OPG gene in the antisense orientation.
Positive_regulation (transfer) of Gene_expression (transfer) of OPG gene in ARH-77
7) Confidence 0.53 Published 2004 Journal Exp. Hematol. Section Body Doc Link 15050745 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Our results indicated that the expression of RANKL in compressed synovial cells enhanced osteoclast formation, whereas continuous compressive force may induce osteoclastic bone destruction in the TMJ.


Positive_regulation (enhanced) of Gene_expression (expression) of RANKL in TMJ
8) Confidence 0.50 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17321443 Disease Relevance 0.06 Pain Relevance 0
This substance also indirectly induces osteoclastic differentiation through the promotion of RANKL expression in bone-marrow stromal cells and osteoblasts.
Positive_regulation (promotion) of Gene_expression (expression) of RANKL in osteoblasts associated with osteoporosis
9) Confidence 0.50 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.53 Pain Relevance 0.04
RANKL mRNA and RANKL protein expressions increased in both ST2 cells and MC3T3-E1 cells in a MIP-1alpha concentration-dependent manner.
Positive_regulation (increased) of Gene_expression (expressions) of RANKL protein in MC3T3-E1
10) Confidence 0.50 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.31 Pain Relevance 0.11
When SB203580, a p38MAPK inhibitor, was added, RANKL mRNA and RANKL protein expression were increased in these cells.
Positive_regulation (increased) of Gene_expression (expression) of RANKL mRNA
11) Confidence 0.50 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.46 Pain Relevance 0.04
CONCLUSIONS: A lentiviral vector can efficiently transfer the native human OPG gene to myeloma cells ex vivo and inhibit myeloma-induced bone destruction, thereby suggesting a therapeutic potential for unmodified, native OPG gene transfer for osteoclast-dependent skeletal disorders.


Positive_regulation (transfer) of Gene_expression (transfer) of OPG gene in osteoclast
12) Confidence 0.46 Published 2004 Journal Exp. Hematol. Section Body Doc Link 15050745 Disease Relevance 0 Pain Relevance 0
Second, RANKL signalling can also promote mineral
Positive_regulation (promote) of Gene_expression (signalling) of RANKL
13) Confidence 0.46 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 0.75 Pain Relevance 0.03
RANKL is produced by prostate cancer bone metastases, enabling these metastases to induce osteolysis through osteoclast activation.
Positive_regulation (enabling) of Gene_expression (produced) of RANKL in osteoclast associated with osteolysis, metastasis and reprotox - general 1
14) Confidence 0.45 Published 2002 Journal Drugs Today Section Abstract Doc Link 12532187 Disease Relevance 1.95 Pain Relevance 0.11
Early studies demonstrated that co-culture of myeloma cells and BMSCs leads to marked induction of RANKL expression by both cell types, and a concomitant downregulation of OPG expression by BMSCs [5]; this illustrates the importance of interactions between myeloma cells and stromal cells.
Positive_regulation (induction) of Gene_expression (expression) of RANKL in stromal cells
15) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.64 Pain Relevance 0.17
These findings of RANKL induction and concomitant OPG downregulation in bone-derived cells in myeloma were subsequently replicated in other studies involving myeloma cell-BMSC and myeloma cell-osteoblast co-cultures [6,7], although these latter studies and others did not observe an increase in RANKL expression in tumor cells [8].
Positive_regulation (increase) of Gene_expression (expression) of RANKL in osteoblast associated with cancer and osteoporosis
16) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.57 Pain Relevance 0
demonstrating the increase of levels of RANKL expression in T cells during acute
Positive_regulation (increase) of Gene_expression (expression) of RANKL in T cells
17) Confidence 0.43 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.11 Pain Relevance 0.03
evidences showed RANKL and OPG presence and activity in early and advanced
Positive_regulation (advanced) of Gene_expression (presence) of RANKL
18) Confidence 0.40 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.02 Pain Relevance 0.03
evidences showed RANKL and OPG presence and activity in early and advanced
Positive_regulation (advanced) of Gene_expression (presence) of OPG
19) Confidence 0.40 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.02 Pain Relevance 0.03
MATERIALS AND METHODS: We used replication-incompetent lentiviral vectors to transfer the unmodified, native human OPG gene ex vivo into human ARH-77 cells injected into severe combined immunodeficient (SCID) mice, to determine gene transfer efficiency as well as the impact on disease progression in this in vivo model.
Positive_regulation (transfer) of Gene_expression (transfer) of OPG gene in ARH-77
20) Confidence 0.36 Published 2004 Journal Exp. Hematol. Section Body Doc Link 15050745 Disease Relevance 0 Pain Relevance 0

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