INT104221

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 20.01
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
blood 6
plasma 2
joints 2
hepatocytes 2
adipose tissue 2
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 496 99.10 Very High Very High Very High
cytokine 77 97.16 Very High Very High Very High
metalloproteinase 4 95.76 Very High Very High Very High
diclofenac 106 94.96 High High
Osteoarthritis 60 93.84 High High
methotrexate 28 92.24 High High
Inflammatory marker 62 88.08 High High
addiction 12 85.76 High High
Leflunomide 55 82.72 Quite High
rheumatoid arthritis 46 70.24 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 296 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 4 100.00 Very High Very High Very High
Obesity 318 99.68 Very High Very High Very High
Aneurism 7 99.62 Very High Very High Very High
INFLAMMATION 575 99.10 Very High Very High Very High
Apoptosis 13 98.76 Very High Very High Very High
Pathologic Dilatation 150 98.00 Very High Very High Very High
Cytomegalovirus Infection 7 97.92 Very High Very High Very High
Diabetes Mellitus 265 97.80 Very High Very High Very High
Coronary Artery Disease 180 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reviewers further conclude that acupuncture has no effect on ESR, CRP, pain, patient's global assessment, number of swollen joints, number of tender joints, general health, disease activity and reduction of analgesics.
Neg (no) Regulation (effect) of Gene_expression (reduction) of CRP in joints
1) Confidence 0.45 Published 2002 Journal Cochrane Database Syst Rev Section Body Doc Link 12137715 Disease Relevance 0 Pain Relevance 0
INVESTIGATIONS: Physical examination, CBC, blood chemistry panel, measurement of erythrocyte sedimentation rate and C-reactive protein level, liver function profile, urinalysis, lumbar puncture, blood cultures, urine cultures, cerebrospinal fluid culture, stool analysis and cultures, multiple viral studies including hepatitis serologies, measurement of antineutrophil cytoplasmic autoantibody levels, urine protein electrophoresis, serum protein electrophoresis, CT of the head, chest, abdomen and pelvis, MRI of the brain, temporal artery biopsy and pathologic analysis, scrotal ultrasonography, right spermatic cord biopsy and pathologic analysis.
Regulation (rate) of Gene_expression (level) of C-reactive protein in blood
2) Confidence 0.45 Published 2008 Journal Nature clinical practice. Urology Section Body Doc Link 18626512 Disease Relevance 0.19 Pain Relevance 0
To limit the possibility that CRP levels may have been affected by intercurrent illness, women were asked not to attend for their blood test on a day they were not well.
Regulation (affected) of Gene_expression (levels) of CRP in blood
3) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 0.11 Pain Relevance 0.09
However, the apparent influence in baseline CRP levels due to CRP polymorphisms may not be large enough to alter CHD risk, which may explain the lack of association between the majority of common haplotypes in the CRP gene and risk of CHD in either the NHS or the HPFS.
Regulation (influence) of Gene_expression (levels) of CRP associated with coronary artery disease
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.55 Pain Relevance 0.22
CRP levels did not differ over the days.
Neg (not) Regulation (differ) of Gene_expression (levels) of CRP
5) Confidence 0.44 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC115848 Disease Relevance 0.14 Pain Relevance 0
CRP expression was observed in all implants in the bronchial wall during initial ischemic damage, and then decreased in the autografts.
Regulation (observed) of Gene_expression (expression) of CRP
6) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.06 Pain Relevance 0
aneurysm, and higher serum CRP levels were observed in
Regulation (observed) of Gene_expression (levels) of CRP associated with aneurism
7) Confidence 0.44 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 1.76 Pain Relevance 0.33
The CRP levels in three of these subjects dropped below 2 ?
Regulation (dropped) of Gene_expression (levels) of CRP
8) Confidence 0.43 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.37 Pain Relevance 0.44
The CRP levels in three of these subjects dropped below 2 ?
Regulation (three) of Gene_expression (levels) of CRP
9) Confidence 0.43 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.37 Pain Relevance 0.41
with CRP and IL-6 were strongest and most consistent for the 8 individuals
Regulation (strongest) of Gene_expression (consistent) of CRP
10) Confidence 0.43 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.22 Pain Relevance 0.28
The finding that treatment with a statin has a rapid inhibitory effect on CRP stimulated IL-6 production is of interest, not only because it demonstrates a rapid anti-inflammatory action of a statin ex vivo,but also because IL-6 is thought to be one of the prime regulators of CRP production [37].
Regulation (regulators) of Gene_expression (production) of CRP associated with inflammation
11) Confidence 0.42 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.23 Pain Relevance 0.11
Thus, it is possible that the major source of postpartum CRP production is the constantly increasing PAM population in the neonatal lung.
Regulation (population) of Gene_expression (source) of CRP in lung
12) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.61 Pain Relevance 0.11
Insulin, for example, has been shown to act as an anti-inflammatory modulator and some oral hypoglycemic agents (OHAs) can affect hs-CRP levels [37,38].
Regulation (affect) of Gene_expression (levels) of hs-CRP associated with inflammation
13) Confidence 0.39 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.43 Pain Relevance 0.11
Tsimane and other Amerindians should be comprehensively investigated for distinct inflammation profiles due to genetic variability in loci affecting expression of CRP [39], apolipoprotein-E [40], mannose-binding lectin (MBL) [41], NR4A nuclear receptor family [42], interleukine-6 (IL-6) [43], IL-1 [44], and toll-like receptor 4 [45].
Regulation (affecting) of Gene_expression (expression) of CRP associated with inflammation and disorder of lipid metabolism
14) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722089 Disease Relevance 0.76 Pain Relevance 0.15
There is a direct effect of statins (rosuvastatin, atorvastatin, simvastatin and pravastatin) on CRP production by human hepatocytes.41–43
Regulation (effect) of Gene_expression (production) of CRP in hepatocytes
15) Confidence 0.39 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.28 Pain Relevance 0.04
The hs-CRP levels became similar after
Regulation (similar) of Gene_expression (levels) of hs-CRP
16) Confidence 0.38 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.05 Pain Relevance 0.03
In conclusion, we found that hs-CRP levels were significantly
Regulation (were) of Gene_expression (levels) of hs-CRP
17) Confidence 0.38 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.00 Pain Relevance 0.08
Examples of such changes are the fluctuations in the levels of CRP, SAA, TNF-?
Regulation (fluctuations) of Gene_expression (levels) of CRP
18) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.70 Pain Relevance 0.20
Additional adjustment for CRP and IL-6 (model 2) changed the mortality risk associated with high IL-10 to a non-significant level (adjusted odds ratio, 1.7; 95% confidence interval, 0.8 to 3.6) (p?
Regulation (changed) of Gene_expression (adjustment) of CRP
19) Confidence 0.32 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.78 Pain Relevance 0
Noteworthy aspects of treatment with tocilizumab are that SAA and CRP levels were normalized in nearly all the patients in whom pre-infusion trough levels of the drug can be detected in blood, that is, tocilizumab can be measured in blood before treatment.
Regulation (normalized) of Gene_expression (levels) of CRP in blood
20) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.11 Pain Relevance 0.18

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