INT104226

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.22
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
dendrites 2
cochlea 1
skin 1
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 20 100.00 Very High Very High Very High
nMDA receptor 18 100.00 Very High Very High Very High
opioid receptor 56 99.92 Very High Very High Very High
addiction 27 99.92 Very High Very High Very High
alcohol 36 99.48 Very High Very High Very High
Physical dependence 1 99.04 Very High Very High Very High
Opioid 15 94.36 High High
Cannabinoid 4 94.24 High High
tolerance 17 86.72 High High
antinociception 2 81.52 Quite High
Disease Link Frequency Relevance Heat
Alcohol Addiction 35 99.92 Very High Very High Very High
Targeted Disruption 17 99.64 Very High Very High Very High
Drug Dependence 2 99.04 Very High Very High Very High
Sprains And Strains 12 94.08 High High
Nociception 13 90.88 High High
Pain 36 80.72 Quite High
Opiate Addiction 2 77.12 Quite High
Ganglion Cysts 72 75.88 Quite High
Stress 5 74.32 Quite High
Diuresis 5 73.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OPRK1 is located on human chromosome 8q11.2.
Localization (located) of OPRK1
1) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.73 Pain Relevance 0.79
However, acute effects of Delta9-tetrahydrocannabinol (THC) and physical dependence were not modified in knockout mice with single deletion of mu (MOR), delta (DOR) or kappa (KOR) opioid receptors.
Localization (deletion) of KOR associated with targeted disruption, physical dependence and opioid receptor
2) Confidence 0.73 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534979 Disease Relevance 0.56 Pain Relevance 0.70
Two of the QTL reported, Morph1 and Morph4 co-localise with the strong candidate genes, Oprk and Oprm, which encode kappa (?
Localization (localise) of Oprk
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 1.19 Pain Relevance 0.77
KOR and NR1 also were colocalized within dendrites, and rarely were observed in the same cell bodies.
Localization (observed) of KOR in dendrites associated with nmda receptor and kappa opioid receptor
4) Confidence 0.17 Published 2002 Journal Brain Res. Section Abstract Doc Link 12137930 Disease Relevance 0 Pain Relevance 0.88
KOR and NR1 also were colocalized within dendrites, and rarely were observed in the same cell bodies.
Localization (colocalized) of KOR in dendrites associated with nmda receptor and kappa opioid receptor
5) Confidence 0.17 Published 2002 Journal Brain Res. Section Abstract Doc Link 12137930 Disease Relevance 0 Pain Relevance 0.87
The aim of the present study was therefore to identify and localize the mu (MOR), delta (DOR) and kappa (KOR) opioid receptor subtypes within the rat cochlea.
Localization (localize) of KOR in cochlea associated with opioid receptor
6) Confidence 0.16 Published 2003 Journal Hear. Res. Section Abstract Doc Link 12855366 Disease Relevance 0 Pain Relevance 0.27
Using immunohistochemistry, DOR and KOR were localized in skin fibroblast-like and mononuclear cells.
Localization (localized) of KOR in skin
7) Confidence 0.12 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16263089 Disease Relevance 0.08 Pain Relevance 0.77
Silencing of SHP-2 blocked this complex formation (Fig. 4 E) and nuclear export of Grb7 and KOR mRNA (Fig. 4 F), which could be rescued by expressing siRNA off-target Flag–SHP-2 (see Materials and methods).
Localization (export) of KOR
8) Confidence 0.03 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Collectively, this study establishes a dual action of EGF through a novel mechanism that couples stimulated nuclear–cytoplasmic export of a KOR mRNA–protein complex and enhanced KOR translation in the cytoplasm (Fig. 5 C).
Localization (export) of KOR
9) Confidence 0.03 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
EGF mediates Grb7-dependent activation of KOR levels and KOR mRNA nuclear export
Localization (export) of KOR
10) Confidence 0.03 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.51 Pain Relevance 0.28
FAK could phosphorylate Grb7 and thereby release KOR mRNA for translation (Tsai et al., 2007).
Localization (release) of KOR
11) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Together, these data suggest that EGF triggers KOR mRNA nuclear export in a Grb7-dependent manner.


Localization (export) of KOR
12) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.14 Pain Relevance 0.07

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