INT104233

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
limb 2
Fgf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 12 98.00 Very High Very High Very High
Restless leg syndrome 4 75.00 Quite High
cINOD 1 75.00 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 8 99.84 Very High Very High Very High
Toxicity 2 99.24 Very High Very High Very High
Cv Unclassified Under Development 12 98.00 Very High Very High Very High
Increased Venous Pressure Under Development 6 84.24 Quite High
Ulcers 2 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene transfer of FGF1 has been demonstrated to successfully promote angiogenesis.
Positive_regulation (transfer) of Gene_expression (transfer) of FGF1
1) Confidence 0.63 Published 2009 Journal Curr Opin Investig Drugs Section Abstract Doc Link 19333884 Disease Relevance 0.34 Pain Relevance 0.14
In phase I and phase II clinical trials, NV1FGF effectively reduced the number of amputations and deaths in the trials, with minimal toxicity, and in conjunction with a sustained increase in mRNA and protein levels of FGF1 and its receptors in patients with critical limb ischemia (CLI).
Positive_regulation (increase) of Gene_expression (levels) of FGF1 in limb associated with toxicity and ischemia
2) Confidence 0.42 Published 2009 Journal Curr Opin Investig Drugs Section Abstract Doc Link 19333884 Disease Relevance 0.71 Pain Relevance 0.41
Basic FGF treatment produced significant enhancement of wound re-epitheliazation at the various concentrations [10, 20, 30, 40, 50 and 70 ng/ml] studied.
Positive_regulation (enhancement) of Gene_expression (produced) of FGF associated with injury
3) Confidence 0.20 Published 2002 Journal Life Sci. Section Abstract Doc Link 12138016 Disease Relevance 0.74 Pain Relevance 0.07

General Comments

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