INT104250

Context Info Confidence 0.69 First Reported 2002 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 17 Total Number 18 Disease Relevance 13.22 Pain Relevance 1.44

extracellular space (SPP1) extracellular region (SPP1) cell adhesion (SPP1) cytoplasm (SPP1)

Anatomy Link Frequency macrophages 2 myocardium 2 plasma 2 osteoclast 2 granulation 2 SPP1 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 152 99.96 Inflammation 119 99.56 Mechanotransduction 8 98.98 Pain 31 92.28 dexamethasone 4 89.20 metalloproteinase 63 83.40 medulla 2 82.16 Inflammatory response 42 75.68 cytokine 34 63.28 Serotonin 6 50.68

Disease Link Frequency Relevance Heat Atherosclerosis 6 100.00 Fibrosis 31 99.96 Respiratory Syncytial Virus 232 99.88 Injury 157 99.84 Pulmonary Fibrosis 130 99.64 INFLAMMATION 162 99.56 Cancer 281 99.52 Metastasis 196 99.38 Myocardial Infarction 32 99.00 Diabetes Mellitus 11 98.96

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also, osteopontin expression is increased in the myocardium after myocardial infarction, and the lack of this mediator is associated with decreased collagen accumulation [25].

Positive_regulation (increased) of Gene_expression (expression) of osteopontin in myocardium associated with myocardial infarction

1) Confidence 0.69 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.67 Pain Relevance 0.24

The data revealed a high incidence of osteopontin expression in chronic calcifying pancreatitis in comparison with its expression in CP without stones (p = 0.0081).

Positive_regulation (incidence) of Gene_expression (expression) of osteopontin

2) Confidence 0.50 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0

Osteopontin expression levels were higher in most IPF lungs than in any control lung (Figure 1B).

Positive_regulation (higher) of Gene_expression (expression) of Osteopontin in lung associated with fibrosis

3) Confidence 0.46 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.80 Pain Relevance 0.40

Elevated expression of SPP1 has been correlated with poor prognosis in prostate tumors and other cancers and it has often been implicated in metastasis to bone and other organs [2,23-28].

Positive_regulation (Elevated) of Gene_expression (expression) of SPP1 associated with cancer, prostate cancer and metastasis

4) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.27 Pain Relevance 0

It has been postulated that metastasis to specific target organs may require not only expression of SPP1 but an additional set of signaling molecules that promote metastasis to the specific organ.

Spec (may) Positive_regulation (require) of Gene_expression (expression) of SPP1 associated with metastasis

5) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.41 Pain Relevance 0.04

SPP1 is a secreted integrin-binding glycoprotein that is overexpressed in various tumors and has been reported to be involved in tumorigenesis and metastasis.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SPP1 associated with cancer and metastasis

6) Confidence 0.35 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 1.07 Pain Relevance 0.06

The OPN SiRNA expression vector was generated using Seqwright DNA Technology Services (Houston, TX).

Positive_regulation (generated) of Gene_expression (expression) of OPN SiRNA

7) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.20 Pain Relevance 0

With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.

Positive_regulation (inducing) of Gene_expression (expression) of osteopontin in osteoclast associated with osteoporosis

8) Confidence 0.31 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.35 Pain Relevance 0.09

Some studies have demonstrated an elevated expression of osteopontin (OPN) in highly invasive metastatic breast and prostate cancer cells [2-4].

Positive_regulation (elevated) of Gene_expression (expression) of OPN associated with prostate cancer

9) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.25 Pain Relevance 0

Analysis of morphology of live PC3 cells by phase contrast microscopy: Over-expression of OPN has been shown to augment the occurrence of multinucleated giant cells in pancreatic adenocarcinoma [35] and macrophages of rat glomerulonephritis [36].

Positive_regulation (expression) of Gene_expression (expression) of OPN in macrophages associated with adenocarcinoma and renal disease

10) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.27 Pain Relevance 0

We show here coclustering of CD44/MMP-9 on the surface is dependent on the expression levels of OPN and CD44 as well as integrin ?

Positive_regulation (dependent) of Gene_expression (expression) of OPN

11) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.71 Pain Relevance 0.04

Conversely, pharmacologically inhibiting mechanotransduction with either blebbistatin or Y27632 resulted in an increase of OPN mRNA expression in both MDA231 and RWGT2 (data not shown).

Positive_regulation (increase) of Gene_expression (expression) of OPN mRNA associated with mechanotransduction

12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0 Pain Relevance 0.12

Free phosphates can induce the mRNA and protein expression of osteogenic markers such as osteopontin, and these phosphates have known effects on the production and nuclear export of a key osteogenesis regulatory gene, Cbfa1 (core binding factor alpha1) [63-65].

Positive_regulation (induce) of Gene_expression (expression) of osteopontin

13) Confidence 0.11 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.15 Pain Relevance 0.04

The mechanism is dependent on increased expression of the atherosclerotic matrix protein osteopontin [134, 137].

Positive_regulation (increased) of Gene_expression (expression) of osteopontin associated with atherosclerosis

14) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.25 Pain Relevance 0.08

M RSV, the expression of osteogenic markers such as vitamin D3 receptor (VD3R), osteocalcin, osteopontin (OPN), and alkaline phosphatase (ALP) was upregulated relative to cells not treated with PDM02 or RSV (Fig. 5).

Positive_regulation (upregulated) of Gene_expression (expression) of osteopontin associated with respiratory syncytial virus

15) Confidence 0.10 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.90 Pain Relevance 0

M RSV, the expression of osteogenic markers such as vitamin D3 receptor (VD3R), osteocalcin, osteopontin (OPN), and alkaline phosphatase (ALP) was upregulated relative to cells not treated with PDM02 or RSV (Fig. 5).

Positive_regulation (upregulated) of Gene_expression (expression) of OPN associated with respiratory syncytial virus

16) Confidence 0.08 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.90 Pain Relevance 0

It has been shown that mast-cell secreted factors, specifically PDGF, could contribute to inflammation-associated fibrosis, inducing the expression of osteopontin by wound granulation tissue fibroblasts [171].

Positive_regulation (inducing) of Gene_expression (expression) of osteopontin in granulation associated with fibrosis, inflammation and injury

17) Confidence 0.07 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2945962 Disease Relevance 1.88 Pain Relevance 0.32

RESULTS: Patients with AS had significantly higher plasma OPN, TNF-alpha and IL-6 levels and more mRNA expression than healthy controls.

Positive_regulation (higher) of Gene_expression (levels) of plasma OPN in plasma

18) Confidence 0.06 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18854347 Disease Relevance 0.14 Pain Relevance 0

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