INT104263

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2008
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.15
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
macrophages 2
tracheal epithelial cells 2
Sympathetic 2
pia mater 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 85 97.84 Very High Very High Very High
Pain threshold 3 96.04 Very High Very High Very High
Morphine 9 95.28 Very High Very High Very High
bradykinin 7 95.12 Very High Very High Very High
analgesia 5 94.60 High High
tolerance 5 94.16 High High
addiction 6 93.60 High High
Migraine 5 87.60 High High
COX-2 inhibitor 1 86.56 High High
Sumatriptan 1 86.48 High High
Disease Link Frequency Relevance Heat
Stress 93 99.84 Very High Very High Very High
Sepsis 5 99.76 Very High Very High Very High
Fever 1 97.76 Very High Very High Very High
Pain 4 96.04 Very High Very High Very High
Otitis Media 134 95.44 Very High Very High Very High
Hypotension 4 94.52 High High
Otitis Media With Effusion 92 91.96 High High
Hyperplasia 4 88.56 High High
Metaplasia 4 88.08 High High
Headache 5 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NO regulation and synthesis via activation of the Ca2+ dependent eNOS or nNOS isozymes can occur in response to a diverse array of agonists that signal through GPCRs, including the widely documented bradykinin and muscarinic acetylcholine receptors signalling pathways, in addition to TP [70,80].
Regulation (regulation) of Positive_regulation (activation) of nNOS associated with agonist and bradykinin
1) Confidence 0.28 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.17
The activity of the constitutive NOS depends on Ca2+ and calmodulin, whereas the inducible NOS is independent of Ca2+.
Neg (independent) Regulation (independent) of Positive_regulation (inducible) of NOS
2) Confidence 0.19 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.18 Pain Relevance 0.15
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (Inducible) of NOS in pia mater associated with stress
3) Confidence 0.19 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.94 Pain Relevance 0.52
The effects of L-Canavanine, a selective inducible nitric oxide synthase (NOS) inhibitor and N(G)-nitro-L-arginine methyl ester (L-NAME), a nonselective NOS inhibitor, on pain threshold and morphine induced analgesia, tolerance and dependence in mice were investigated and compared.
Spec (investigated) Regulation (effects) of Spec (investigated) Positive_regulation (inducible) of nitric oxide synthase associated with addiction, pain threshold, tolerance, analgesia and morphine
4) Confidence 0.08 Published 2003 Journal Life Sci. Section Abstract Doc Link 12597993 Disease Relevance 0.16 Pain Relevance 1.06
Sympathetic nerve activation during sepsis appears to depend on the induction of NOS and COX; the COX pathway is involved in the elevation of temperature and in the activation of sympathetic nerve activity but not in the hypotension.
Spec (appears) Regulation (depend) of Positive_regulation (induction) of NOS in Sympathetic associated with hypotension and sepsis
5) Confidence 0.08 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144036 Disease Relevance 0.95 Pain Relevance 0.20
was reported to stimulate secretion of mucin by guinea pig tracheal epithelial cells via mechanisms involving activation of NO synthase (NOS) and generation of NO (243).
Regulation (involving) of Positive_regulation (activation) of NOS in tracheal epithelial cells
6) Confidence 0.02 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.91 Pain Relevance 0.06
Inhibitory effects of these drugs on lipopolysaccharide (LPS)-induction of inducible nitric oxide synthase (iNOS) and LPS-stimulated translocation of NficB were determined by use of RAW 264.7 murine macrophages.
Regulation (effects) of Positive_regulation (induction) of nitric oxide synthase in macrophages
7) Confidence 0.01 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0

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