INT104284

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.57
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch3) plasma membrane (Notch3) nucleus (Notch3)
Anatomy Link Frequency
Notch 1
smooth muscle cells 1
Notch3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 2 99.72 Very High Very High Very High
Migraine 7 95.08 Very High Very High Very High
headache 1 88.96 High High
fibrosis 1 84.28 Quite High
Substantia nigra 7 83.00 Quite High
medulla 1 80.80 Quite High
imagery 2 74.12 Quite High
ketamine 3 66.72 Quite High
agonist 1 56.44 Quite High
dopamine receptor 1 56.12 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 2 99.72 Very High Very High Very High
Atrial Heart Septal Defects 1 99.36 Very High Very High Very High
Cadasil 23 99.20 Very High Very High Very High
Disease 44 98.04 Very High Very High Very High
Stroke 9 97.48 Very High Very High Very High
Leukoencephalopathies 5 97.40 Very High Very High Very High
Cardiovascular Disease 1 96.00 Very High Very High Very High
Headache 6 95.08 Very High Very High Very High
Dementia 4 94.00 High High
Migraine With Aura 4 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The aim of the present study was to evaluate whether the functional Notch3 polymorphism T6746C, which is not causative for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), might be a risk factor for migraine.
Neg (not) Positive_regulation (causative) of Notch3 associated with migraine, cadasil and leukoencephalopathies
1) Confidence 0.50 Published 2006 Journal Headache Section Abstract Doc Link 16492242 Disease Relevance 0.36 Pain Relevance 0.17
Here we report an update on mutations of the Notch3 gene and some information on the pathogenesis of the disease.
Positive_regulation (update) of Notch3 gene associated with disease
2) Confidence 0.47 Published 2005 Journal Neurol. Sci. Section Abstract Doc Link 15995828 Disease Relevance 0.77 Pain Relevance 0.08
The progressive degeneration of smooth muscle cells in small blood vessels could be caused by an abnormal accumulation of the Notch3 ectodomain.
Positive_regulation (accumulation) of Notch3 in smooth muscle cells
3) Confidence 0.45 Published 2009 Journal Rinsho Byori Section Abstract Doc Link 19363995 Disease Relevance 0.99 Pain Relevance 0.08
CADASIL is caused by single missense mutations or small deletions in Notch3 gene encoding a transmembrane receptor Notch3, of which upon ligand binding a nuclear signaling protein is generated by regulated intramembrane proteolysis.
Positive_regulation (generated) of Notch3 associated with cadasil
4) Confidence 0.45 Published 2002 Journal Brain Pathol. Section Abstract Doc Link 12146805 Disease Relevance 1.36 Pain Relevance 0.14
Notch3 mutations have been suggested to induce an abnormally high incidence of atrial septal defects in a family harbouring an Arg141Cys pathogenetic mutation.
Positive_regulation (induce) of Notch3 associated with atrial heart septal defects
5) Confidence 0.45 Published 2009 Journal Eur. Neurol. Section Abstract Doc Link 18948701 Disease Relevance 0.84 Pain Relevance 0.17
Ten-micron-thick tissue sections were stained to visualize the cells that were positive for TH, ubiquitin, Notch-3, IBA-1, GFAP and iNOS, according to a previously described immunohistochemical procedure [40].
Positive_regulation (positive) of Notch-3 in Notch
6) Confidence 0.24 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0 Pain Relevance 0.13
[Case of CADASIL showing spontaneous subcortical hemorrhage with a novel mutation of Notch3 gene].
Positive_regulation (mutation) of Notch3 gene associated with cadasil and cva
7) Confidence 0.12 Published 2006 Journal Rinsho Shinkeigaku Section Title Doc Link 17260807 Disease Relevance 1.25 Pain Relevance 0.22

General Comments

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