INT104289

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 4.46
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
liver 4
skeletal muscle 3
fat 2
body 2
white fat 1
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 98.76 Very High Very High Very High
tolerance 51 98.08 Very High Very High Very High
cytokine 3 94.24 High High
Inflammatory response 2 93.24 High High
antagonist 7 83.28 Quite High
Central nervous system 2 81.56 Quite High
metalloproteinase 1 79.52 Quite High
alcohol 2 75.00 Quite High
Pain threshold 1 75.00 Quite High
cerebral cortex 6 54.32 Quite High
Disease Link Frequency Relevance Heat
Obesity 240 99.72 Very High Very High Very High
Targeted Disruption 10 99.44 Very High Very High Very High
Body Weight 179 99.00 Very High Very High Very High
Pain 4 98.76 Very High Very High Very High
Fatty Liver 6 98.08 Very High Very High Very High
Atherosclerosis 7 96.20 Very High Very High Very High
Hyperlipidemia 14 93.72 High High
INFLAMMATION 17 92.88 High High
Hyperinsulinism 40 91.48 High High
Death 3 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased UCP2 expression in steatotic liver appears to play a reactive and protective role in limiting oxidative damage associated with increased fatty-acid oxidation [13-16].
Positive_regulation (Increased) of Gene_expression (expression) of UCP2 in liver
1) Confidence 0.59 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.48 Pain Relevance 0.07
In comparison with lean animals, hepatic gene expression of UCP2 is increased in ob/ob mice and DIO rats [11,12].
Positive_regulation (increased) of Gene_expression (expression) of UCP2 associated with obesity
2) Confidence 0.59 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.49 Pain Relevance 0.07
Increased fatty acid levels lead to elevations in hepatic UCP2 expression in rats [24], and the circulating free fatty acid concentration correlates with UCP2 expression in white fat and skeletal muscle [25], suggesting that UCP2 is important for the metabolic adaptation of these tissues to excessive fatty acid.
Positive_regulation (elevations) of Gene_expression (expression) of UCP2 in skeletal muscle
3) Confidence 0.59 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.19 Pain Relevance 0.03
In adipocytes and skeletal muscle tissue, UCP2 expression appears to increase following high-fat feeding.
Spec (appears) Positive_regulation (increase) of Gene_expression (expression) of UCP2 in fat associated with obesity
4) Confidence 0.56 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.54 Pain Relevance 0
In UCP2 overexpressing mice, sensitivity to ethanol was decreased compared to that of wild-type animals, while UCP2 knockouts had increased ethanol sensitivity.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of UCP2
5) Confidence 0.50 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12147287 Disease Relevance 0.34 Pain Relevance 0.53
Therefore, it is plausible to hypothesize that functional UCP2 gene polymorphisms leading to reduced expression of UCP2 may be related to a proinflammatory status and possibly to the development and progression of atherosclerosis.
Positive_regulation (leading) of Gene_expression (expression) of UCP2 associated with atherosclerosis
6) Confidence 0.46 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.55 Pain Relevance 0.16
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Positive_regulation (on) of Gene_expression (expression) of UCP2 mRNA
7) Confidence 0.43 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
Consistent with these observations we found elevated UCP2 expression levels in the livers of HFD-fed GhrR KO mice.
Positive_regulation (elevated) of Gene_expression (expression) of UCP2 in livers
8) Confidence 0.40 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.16 Pain Relevance 0.04
In addition, gene expression of uncoupling protein 2 (UCP2), whose expression is involved in energy balance, was upregulated by 2.55-fold in the berberine group.
Positive_regulation (upregulated) of Gene_expression (expression) of UCP2
9) Confidence 0.38 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.13 Pain Relevance 0.03
Reductions in body weight and adiposity by fenofibrate are associated with elevation of hepatic UCP2 expression [44].
Positive_regulation (elevation) of Gene_expression (expression) of UCP2 in body associated with body weight
10) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.75 Pain Relevance 0.05
Increased fatty acid levels lead to elevations in hepatic UCP2 expression in rats [24], and the circulating free fatty acid concentration correlates with UCP2 expression in white fat and skeletal muscle [25], suggesting that UCP2 is important for the metabolic adaptation of these tissues to excessive fatty acid.
Positive_regulation (elevations) of in white fat Gene_expression (expression) of UCP2 in skeletal muscle
11) Confidence 0.20 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.19 Pain Relevance 0.03
-cell function in part via increased UCP-2 expression, we clearly demonstrated in the present study (microarray and PCR data) that the polyunsaturated NEFA AA did not increase Ucp-2 expression, therefore avoiding any UCP-2-dependent deleterious effects associated with saturated NEFAs.
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of Ucp-2
12) Confidence 0.19 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.08 Pain Relevance 0
-cell function in part via increased UCP-2 expression, we clearly demonstrated in the present study (microarray and PCR data) that the polyunsaturated NEFA AA did not increase Ucp-2 expression, therefore avoiding any UCP-2-dependent deleterious effects associated with saturated NEFAs.
Positive_regulation (increased) of Gene_expression (expression) of UCP-2
13) Confidence 0.19 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.09 Pain Relevance 0

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