INT104290

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 33
Disease Relevance 12.81
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
liver 5
fat 3
skeletal muscle 2
white fat 2
macrophages 1
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 10 98.76 Very High Very High Very High
tolerance 143 98.08 Very High Very High Very High
Inflammation 55 95.64 Very High Very High Very High
cytokine 11 93.48 High High
Inflammatory response 10 92.48 High High
antagonist 14 83.28 Quite High
Central nervous system 11 81.56 Quite High
metalloproteinase 5 78.76 Quite High
alcohol 4 75.00 Quite High
Pain threshold 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Obesity 532 99.84 Very High Very High Very High
Targeted Disruption 55 99.44 Very High Very High Very High
Lifespan 33 99.38 Very High Very High Very High
Pain 8 98.76 Very High Very High Very High
Body Weight 316 98.58 Very High Very High Very High
Fatty Liver 15 98.08 Very High Very High Very High
Atherosclerosis 43 96.20 Very High Very High Very High
Aging 16 96.08 Very High Very High Very High
INFLAMMATION 71 95.64 Very High Very High Very High
Insulin Resistance 74 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In UCP2 overexpressing mice, sensitivity to ethanol was decreased compared to that of wild-type animals, while UCP2 knockouts had increased ethanol sensitivity.
Gene_expression (overexpressing) of UCP2
1) Confidence 0.78 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12147287 Disease Relevance 0.34 Pain Relevance 0.53
In addition, UCP2 expression was inversely correlated with the impairment of pain and temperature sensation induced by ethanol.
Gene_expression (expression) of UCP2 associated with pain
2) Confidence 0.78 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12147287 Disease Relevance 0.34 Pain Relevance 0.56
Therefore, it is plausible to hypothesize that functional UCP2 gene polymorphisms leading to reduced expression of UCP2 may be related to a proinflammatory status and possibly to the development and progression of atherosclerosis.
Gene_expression (expression) of UCP2 associated with atherosclerosis
3) Confidence 0.76 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.55 Pain Relevance 0.16
Likewise, in the present study hepatic expression of UCP2 mRNA was lower in HFD-fed GhrR KO mice.
Gene_expression (expression) of UCP2 mRNA
4) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.13 Pain Relevance 0
Ghrelin deficiency has been associated previously with a decrease in mitochondrial UCP2 mRNA expression in the livers of chow-fed mice [3].
Gene_expression (expression) of UCP2 mRNA in livers
5) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.13 Pain Relevance 0
Increased fatty acid levels lead to elevations in hepatic UCP2 expression in rats [24], and the circulating free fatty acid concentration correlates with UCP2 expression in white fat and skeletal muscle [25], suggesting that UCP2 is important for the metabolic adaptation of these tissues to excessive fatty acid.
Gene_expression (expression) of UCP2 in skeletal muscle
6) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.18 Pain Relevance 0.03
Taken together, our results suggest that lower expression of UCP2 mRNA of liver reflects improved lipid metabolism in HFD-fed GhrR KO mice and likely contributes to the overall insulin sensitivity in these animals.
Gene_expression (expression) of UCP2 mRNA in liver
7) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.12 Pain Relevance 0
Increased UCP2 expression in steatotic liver appears to play a reactive and protective role in limiting oxidative damage associated with increased fatty-acid oxidation [13-16].
Gene_expression (expression) of UCP2 in liver
8) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.48 Pain Relevance 0.07
Effects of GhrR KO on UCP1 and UCP2 mRNA expression in response to HFD
Gene_expression (expression) of UCP2 mRNA
9) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.47 Pain Relevance 0.11
Increased fatty acid levels lead to elevations in hepatic UCP2 expression in rats [24], and the circulating free fatty acid concentration correlates with UCP2 expression in white fat and skeletal muscle [25], suggesting that UCP2 is important for the metabolic adaptation of these tissues to excessive fatty acid.
Gene_expression (expression) of UCP2 in skeletal muscle
10) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.18 Pain Relevance 0.03
In comparison with lean animals, hepatic gene expression of UCP2 is increased in ob/ob mice and DIO rats [11,12].
Gene_expression (expression) of UCP2 associated with obesity
11) Confidence 0.66 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.49 Pain Relevance 0.07
In adipocytes and skeletal muscle tissue, UCP2 expression appears to increase following high-fat feeding.
Gene_expression (expression) of UCP2 in fat associated with obesity
12) Confidence 0.63 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.49 Pain Relevance 0
UCP2 is expressed in spleen, lung, macrophages, and T cells, which suggests a role for UCP2 in the regulation of immunity and inflammatory responsiveness [7].
Gene_expression (expressed) of UCP2 in T cells associated with inflammation
13) Confidence 0.59 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.79 Pain Relevance 0.12
mRNA expression of UCP1 and UCP2 in WAT and BAT
Gene_expression (expression) of UCP2 associated with obesity
14) Confidence 0.56 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.32 Pain Relevance 0.03
In agreement with UCR index, the level of expression from the gene encoding the uncoupling protein two (Ucp2) was unchanged, suggesting that mitochondrial respiration was not uncoupled (Fig. 6B).
Gene_expression (expression) of Ucp2
15) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0 Pain Relevance 0
In the present study GhrR KO mice fed a HFD showed significantly reduced UCP2 expression relative to HFD-fed WT mice (Figure 6A), consistent with the decreased hepatic steatosis in HFD-fed GhrR KO mice [2].
Gene_expression (expression) of UCP2
16) Confidence 0.52 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.38 Pain Relevance 0.06
Additionally, the levels of UCP2 and UCP1 were reduced in the liver and BAT, respectively, in GhrR KO mice relative to WT mice.


Gene_expression (levels) of UCP2 in liver
17) Confidence 0.52 Published 2011 Journal BMC Physiol Section Abstract Doc Link PMC3024223 Disease Relevance 0.24 Pain Relevance 0.03
Consistent with these observations we found elevated UCP2 expression levels in the livers of HFD-fed GhrR KO mice.
Gene_expression (expression) of UCP2 in livers
18) Confidence 0.52 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.16 Pain Relevance 0.04
In addition, gene expression of uncoupling protein 2 (UCP2), whose expression is involved in energy balance, was upregulated by 2.55-fold in the berberine group.
Gene_expression (expression) of UCP2
19) Confidence 0.49 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.07 Pain Relevance 0
In addition, gene expression of uncoupling protein 2 (UCP2), whose expression is involved in energy balance, was upregulated by 2.55-fold in the berberine group.
Gene_expression (expression) of uncoupling protein 2
20) Confidence 0.49 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.07 Pain Relevance 0

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