INT104291

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.71
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
livers 1
adipose tissue 1
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 2 99.48 Very High Very High Very High
Central nervous system 2 99.32 Very High Very High Very High
tolerance 26 94.76 High High
Pain 5 88.36 High High
antagonist 1 82.40 Quite High
qutenza 4 79.08 Quite High
Pain threshold 1 75.00 Quite High
Analgesic 1 25.00 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 51 100.00 Very High Very High Very High
Body Weight 35 97.80 Very High Very High Very High
Poisoning 1 97.04 Very High Very High Very High
Targeted Disruption 2 90.24 High High
Pain 4 88.36 High High
Hepatocellular Cancer 3 86.80 High High
Insulin Resistance 23 82.40 Quite High
Metabolic Disorder 5 79.84 Quite High
Diabetes Mellitus 69 77.60 Quite High
Weight Gain 12 20.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol.
Positive_regulation (activation) of UCP2 associated with tolerance, poisoning and alcohol
1) Confidence 0.70 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12147287 Disease Relevance 0.40 Pain Relevance 0.56
Moreover, berberine could upregulate UCP2.
Positive_regulation (upregulate) of UCP2
2) Confidence 0.56 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.40 Pain Relevance 0
An increase in UCP2 levels might be expected to increase energy expenditure and decrease the risk of obesity.
Positive_regulation (increase) of UCP2 associated with obesity
3) Confidence 0.56 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.55 Pain Relevance 0
Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue.
Positive_regulation (increased) of UCP2 in adipose tissue associated with obesity
4) Confidence 0.42 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12959953 Disease Relevance 0.47 Pain Relevance 0.15
Consistent with these observations we found elevated UCP2 expression levels in the livers of HFD-fed GhrR KO mice.
Positive_regulation (elevated) of UCP2 in livers
5) Confidence 0.40 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.16 Pain Relevance 0.04
We speculated that bererine could upregulate UCP2, increase energy dissipation, and decrease the risk of obesity.
Positive_regulation (upregulate) of UCP2 associated with obesity
6) Confidence 0.38 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.64 Pain Relevance 0
NEFAs increase UCP-2 mRNA and protein levels in several cells including ?
Positive_regulation (increase) of UCP-2 mRNA
7) Confidence 0.17 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.09 Pain Relevance 0

General Comments

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