INT104293

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
liver 1
respiratory 1
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 8 99.20 Very High Very High Very High
alcohol 2 98.48 Very High Very High Very High
Central nervous system 2 94.88 High High
Inflammation 9 87.80 High High
Pain 5 83.92 Quite High
Pain threshold 1 75.00 Quite High
Analgesic 1 25.00 Low Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 1 99.80 Very High Very High Very High
Obesity 15 91.20 High High
Cardiovascular Disease 7 90.32 High High
INFLAMMATION 12 87.80 High High
Pain 4 83.92 Quite High
Atherosclerotic Plaque 1 82.20 Quite High
Rupture 1 81.00 Quite High
Atherosclerosis 7 78.64 Quite High
Diabetes Mellitus 15 70.00 Quite High
Impaired Glucose Tolerance 2 54.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol.
Negative_regulation (inhibition) of UCP2 associated with tolerance, poisoning and alcohol
1) Confidence 0.59 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12147287 Disease Relevance 0.39 Pain Relevance 0.54
Uncoupling protein 2 (UCP2) uncouples the substrate oxidation from ATP synthesis, thus decreasing ATP production by the mitochondrial respiratory chain.
Negative_regulation (decreasing) of UCP2 in respiratory
2) Confidence 0.42 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.81 Pain Relevance 0.12
Additionally, the levels of UCP2 and UCP1 were reduced in the liver and BAT, respectively, in GhrR KO mice relative to WT mice.


Negative_regulation (reduced) of UCP2 in liver
3) Confidence 0.16 Published 2011 Journal BMC Physiol Section Abstract Doc Link PMC3024223 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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