INT104300

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.46
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
neutrophils 6
mononuclear phagocyte 4
plasma 2
T-cells 2
Sell (Mus musculus)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 7 98.04 Very High Very High Very High
cINOD 10 95.12 Very High Very High Very High
Pain 4 87.72 High High
anesthesia 5 85.52 High High
ketamine 5 84.56 Quite High
aspirin 1 80.80 Quite High
psoriasis 44 79.00 Quite High
diclofenac 1 78.52 Quite High
Catecholamine 1 76.72 Quite High
Inflammation 191 76.28 Quite High
Disease Link Frequency Relevance Heat
Adhesions 46 100.00 Very High Very High Very High
Stress 6 99.40 Very High Very High Very High
Complex Regional Pain Syndromes 7 98.04 Very High Very High Very High
Pain 3 87.72 High High
Psoriasis 50 79.00 Quite High
Hyperplasia 1 77.60 Quite High
Injury 30 76.96 Quite High
INFLAMMATION 173 76.28 Quite High
Pneumonia 34 75.20 Quite High
Cancer 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of a carboxylic acid group in the diphenylamine (N-phenylanthranilic acid) highly increased its ability to reduce the L-selectin surface expression in neutrophils.
Negative_regulation (reduce) of Gene_expression (expression) of L-selectin in neutrophils
1) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12147693 Disease Relevance 0.55 Pain Relevance 0.66
I/R leads to a nonsignificant decrease in CD62L expression in WT F4/80 cells, whereas a significant decrease in CD62L expression was observed in MC3R-null animals (Table 3), suggesting that the mononuclear phagocyte compartment is highly activated in the MC3R-null animals after I/R.


Negative_regulation (decrease) of Gene_expression (expression) of CD62L in mononuclear phagocyte
2) Confidence 0.44 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.20 Pain Relevance 0
I/R leads to a nonsignificant decrease in CD62L expression in WT F4/80 cells, whereas a significant decrease in CD62L expression was observed in MC3R-null animals (Table 3), suggesting that the mononuclear phagocyte compartment is highly activated in the MC3R-null animals after I/R.


Negative_regulation (decrease) of Gene_expression (expression) of CD62L in mononuclear phagocyte
3) Confidence 0.44 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.19 Pain Relevance 0
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Negative_regulation (reduced) of Gene_expression (expression) of L-selectin in neutrophils
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.08 Pain Relevance 0.04
Postsinusoidal rolling was further reduced to baseline following injection of an anti-P-selectin or anti-L-selectin MAb.
Negative_regulation (reduced) of Gene_expression (injection) of L-selectin
5) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.51 Pain Relevance 0.20
LPS induced a significant activation of lung-marginated neutrophils, promoting shedding of L-selectin (i.e. reduced expression), and upregulation of CD11b.
Negative_regulation (shedding) of Gene_expression (expression) of L-selectin in neutrophils
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.13 Pain Relevance 0.04
More extensive phenotyping failed to demonstrate uniform loss of CD62L or CCR7 expression on all TCR?
Negative_regulation (loss) of Gene_expression (expression) of CD62L
7) Confidence 0.18 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0 Pain Relevance 0
As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis.
Negative_regulation (decreased) of Gene_expression (expression) of CD62L in plasma associated with stress and reflex sympathetic dystrophy
8) Confidence 0.10 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17702656 Disease Relevance 1.22 Pain Relevance 0.81
In addition to reduced CD11a expression on the surface of CD3+ T-cells, binding of efalizumab also causes a reduced expression of other adhesion molecules, such as CD11b, L-selectin or ?
Negative_regulation (reduced) of Gene_expression (expression) of L-selectin in T-cells associated with adhesions
9) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.60 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox