INT104320

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adk) mitochondrion (Ado) nucleus (Adk)
kinase activity (Adk)
Adk (Rattus norvegicus)
Ado (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 10 100.00 Very High Very High Very High
Antihyperalgesic 2 100.00 Very High Very High Very High
antinociception 1 96.72 Very High Very High Very High
agonist 7 95.24 Very High Very High Very High
Antinociceptive 2 93.64 High High
Thermal hyperalgesia 5 92.68 High High
antagonist 2 68.88 Quite High
Inflammation 1 41.36 Quite Low
Pain 1 40.68 Quite Low
hyperexcitability 1 38.24 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 5 92.68 High High
INFLAMMATION 1 41.36 Quite Low
Pain 1 40.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that AK inhibitors produce specific antihyperalgesic effects via an interaction with ADO A(1) and A(2A) receptors at doses that lack detectable effects on exploratory motor activity and rotorod performance and offer an improved separation between antinociceptive and motor impairing effects as compared to ADO receptor agonists.
AK Binding (interaction) of ADO associated with antihyperalgesic, adenocard, agonist and antinociceptive
1) Confidence 0.33 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151032 Disease Relevance 0.30 Pain Relevance 1.12

General Comments

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