INT104324

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 9.79
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat)
molecular_function (Baat) lipid metabolic process (Baat)
Anatomy Link Frequency
BAT 4
body 2
Baat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 8 83.72 Quite High
fluoxetine 3 78.88 Quite High
Serotonin 3 70.24 Quite High
Neurotransmitter 4 65.68 Quite High
anesthesia 5 10.00 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 223 100.00 Very High Very High Very High
Weight Loss 24 99.90 Very High Very High Very High
Hypoxia 272 99.20 Very High Very High Very High
Targeted Disruption 4 97.72 Very High Very High Very High
Body Weight 28 96.24 Very High Very High Very High
Apnoea 56 88.96 High High
Depression 8 83.72 Quite High
Stress 8 72.84 Quite High
Sleep Disorders 20 64.08 Quite High
Syndrome 12 58.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In series 2, anesthetized rats (ketamine-based anesthesia) were given propranolol, reserpine, or diazepam intraperitoneally before (18)F-FDG injection to determine whether the drug reduced (18)F-FDG uptake in BAT.
Spec (whether) Negative_regulation (reduced) of BAT in BAT
1) Confidence 0.38 Published 2004 Journal J. Nucl. Med. Section Body Doc Link 15235065 Disease Relevance 0.07 Pain Relevance 0
FEN produced a significant depletion of BAT NE content, and the magnitude of BAT NE depletion was related to the dose of FEN (-57.4% at 3 mg/kg dose and -75.9% at 10 mg/kg dose).
Negative_regulation (depletion) of BAT in BAT associated with obesity
2) Confidence 0.31 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151039 Disease Relevance 0.78 Pain Relevance 0.10
FEN produced a significant depletion of BAT NE content, and the magnitude of BAT NE depletion was related to the dose of FEN (-57.4% at 3 mg/kg dose and -75.9% at 10 mg/kg dose).
Negative_regulation (depletion) of BAT in BAT associated with obesity
3) Confidence 0.31 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151039 Disease Relevance 0.78 Pain Relevance 0.09
However, the extent of BAT NE depletion was equal at 22 and 4 degrees C.
Negative_regulation (depletion) of BAT in BAT associated with obesity
4) Confidence 0.31 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151039 Disease Relevance 0.76 Pain Relevance 0.11
To elucidate what causes the decrease in BAT it will be necessary to measure the amount of UCP1 or at least the protein amount in the BAT in future experiments.
Negative_regulation (decrease) of BAT associated with obesity
5) Confidence 0.23 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.84 Pain Relevance 0.12
The finding of body mass loss and BAT reduction in rats submitted to IIH is original.
Negative_regulation (reduction) of BAT in body associated with hypoxia and obesity
6) Confidence 0.17 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.81 Pain Relevance 0
This is the first report of weight loss and reduction of BAT under intermittent hypoxia.
Negative_regulation (reduction) of BAT associated with weight loss, hypoxia and obesity
7) Confidence 0.17 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.96 Pain Relevance 0
The finding of body mass loss and BAT reduction in rats submitted to IIH is original.
Negative_regulation (loss) of BAT in body associated with hypoxia and obesity
8) Confidence 0.17 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.80 Pain Relevance 0

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