INT10433

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 6.55
Pain Relevance 12.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Junb) nucleus (Junb) DNA binding (Junb)
Anatomy Link Frequency
CPu 7
IMG 4
DRN 2
nucleus accumbens 2
neurons 2
Junb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 63 100.00 Very High Very High Very High
noradrenaline 1 99.84 Very High Very High Very High
withdrawal 12 99.80 Very High Very High Very High
Nucleus accumbens 14 99.68 Very High Very High Very High
qutenza 25 99.56 Very High Very High Very High
Raphe 6 99.38 Very High Very High Very High
Central grey 12 99.08 Very High Very High Very High
Spinal cord 3 99.04 Very High Very High Very High
Thalamus 14 98.96 Very High Very High Very High
Versed 2 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 40 99.84 Very High Very High Very High
Urological Neuroanatomy 12 99.08 Very High Very High Very High
INFLAMMATION 1 98.56 Very High Very High Very High
Stress 17 97.20 Very High Very High Very High
Cv Unclassified Under Development 2 96.44 Very High Very High Very High
Opiate Addiction 1 95.44 Very High Very High Very High
Drug Dependence 1 95.36 Very High Very High Very High
Colitis 12 94.12 High High
Aids-related Complex 1 92.68 High High
Nociception 2 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies from this laboratory have demonstrated that acute administration of morphine induces the immediate-early genes (IEGs) c-Fos and JunB in the rat caudate putamen (CPu).
Positive_regulation (induces) of JunB in CPu associated with morphine
1) Confidence 0.70 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 0.57
JunB was induced in the same regions of the caudate-putamen as found for c-Fos, but was not induced in the nucleus accumbens or thalamus.
Neg (not) Positive_regulation (induced) of JunB in caudate-putamen associated with nucleus accumbens and thalamus
2) Confidence 0.67 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548308 Disease Relevance 0 Pain Relevance 0.49
JunB was induced in the same regions of the caudate-putamen as found for c-Fos, but was not induced in the nucleus accumbens or thalamus.
Positive_regulation (induced) of JunB in caudate-putamen associated with nucleus accumbens and thalamus
3) Confidence 0.67 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548308 Disease Relevance 0 Pain Relevance 0.47
In the caudate-putamen, JunB induction was still present 3 h after injection.
Positive_regulation (induction) of JunB in caudate-putamen
4) Confidence 0.67 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548308 Disease Relevance 0 Pain Relevance 0.49
These results suggest that morphine acts within the PAG-DRN to exert rapid behavioral effects and to induce c-Fos and JunB in the striatum.
Positive_regulation (induce) of JunB in DRN associated with central grey and morphine
5) Confidence 0.66 Published 1999 Journal Brain Res. Section Abstract Doc Link 10526114 Disease Relevance 0.34 Pain Relevance 0.92
The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA.
Positive_regulation (induction) of junB
6) Confidence 0.65 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.11
A strong induction of junB, a weak induction of c-fos and c-jun, but not of junD, was seen in nucleus accumbens.
Positive_regulation (induction) of junB in nucleus accumbens associated with nucleus accumbens
7) Confidence 0.65 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
By using in situ hybridization of adjacent sections we found a rapid, transient, and dose-dependent increase of c-fos, c-jun, and junB by caffeine in striatum, especially in the lateral part.
Positive_regulation (increase) of junB in lateral
8) Confidence 0.65 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.04
An increase in the IEG protein, Jun-B, was also seen following 7 but not 14 days of withdrawal in both the dorsomedial and dorsolateral CPu.
Positive_regulation (increase) of Jun-B in CPu associated with withdrawal
9) Confidence 0.61 Published 1999 Journal Brain Res. Section Abstract Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.98
Previous studies from this laboratory have demonstrated that acute, systemic administration of morphine results in an induction of the immediate-early gene (IEG) proteins, c-Fos and Jun-B, in the dorsomedial portion of the rat caudate-putamen (CPu).
Positive_regulation (induction) of Jun-B in CPu associated with morphine
10) Confidence 0.61 Published 1999 Journal Brain Res. Section Abstract Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.62
Stimulation with nicotine also caused a drastic increase in the mRNA levels, whereas muscarine only induced moderate elevations. c-fos and c-jun were induced strongly in adrenaline cells and only weakly in noradrenaline cells. junB was upregulated mainly in adrenaline cells.
Positive_regulation (upregulated) of junB associated with nicotine and noradrenaline
11) Confidence 0.48 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.45
In the CPu of beta-FNA treated rats, morphine-induced c-Fos and JunB were attenuated compared to vehicle-infused rats.
Positive_regulation (morphine-induced) of JunB in CPu associated with morphine
12) Confidence 0.48 Published 1999 Journal Brain Res. Section Abstract Doc Link 10526114 Disease Relevance 0.26 Pain Relevance 0.97
A strong induction of junB, a weak induction of c-fos and c-jun, but not of junD, was seen in nucleus accumbens.
Positive_regulation (induction) of junB in nucleus accumbens associated with nucleus accumbens
13) Confidence 0.47 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
While c-Fos, Fra-2 and JunB were increased in response to either stimuli, only Fra-1, c-Jun and JunD were increased by PMA.
Positive_regulation (increased) of JunB
14) Confidence 0.46 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.04
The pre-administration with L-NAME further increased KA-induced c-jun and c-fos mRNA levels in addition to their protein product levels, although the pre-treatment with L-NAME did not affect KA-induced FosB, Fra-2, JunB, and JunD protein levels at 6 h after treatment.
Positive_regulation (induced) of JunB
15) Confidence 0.40 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
Rapid increases in c-fos, fos-B, jun-B, and c-jun mRNA levels accompany withdrawal, with the relative level of induction correlating with the severity of physical dependence.
Positive_regulation (increases) of jun-B associated with physical dependence and withdrawal
16) Confidence 0.36 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838131 Disease Relevance 0.51 Pain Relevance 0.81
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, Fra-2, FosB, c-Jun, and JunB protein levels, which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin.
Positive_regulation (increased) of JunB
17) Confidence 0.33 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, Fra-2, FosB, c-Jun, and JunB protein levels, which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin.
Positive_regulation (increases) of JunB
18) Confidence 0.33 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
Several commonly used anesthetic agents such as midazolam and thiopental were shown to elicit rapid and transient induction of several immediate early genes in neurons, including c-Fos, Egr-1 and Jun B [12,13].
Positive_regulation (induction) of Jun B in neurons associated with versed
19) Confidence 0.33 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.29 Pain Relevance 0.58
In addition, C2 ceramide also increased AP-1 proteins, such as Fra-1, c-Jun, JunB and JunD, and phosphorylation of CREB.
Positive_regulation (increased) of JunB
20) Confidence 0.32 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox