INT104335

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Anatomy Link Frequency
nerve 1
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 7 97.50 Very High Very High Very High
tetrodotoxin 2 96.94 Very High Very High Very High
gABA 2 94.16 High High
antagonist 20 84.28 Quite High
agonist 12 72.60 Quite High
Potency 16 50.00 Quite Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 65 95.76 Very High Very High Very High
Sprains And Strains 3 31.96 Quite Low
Body Weight 3 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional release studies performed in the presence of tetrodotoxin suggested that the dopamine release-stimulating M4 receptors are probably located on neuronal cell bodies, but that the release-facilitating M5 and the release-inhibiting M3 receptors are likely to be located on nerve terminals.
Localization (release) of M3 in nerve associated with tetrodotoxin and dopamine
1) Confidence 0.62 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12151512 Disease Relevance 0.14 Pain Relevance 0.49
The binding affinities (pKD, negative log dissociation constant) of AF-DX 116 for the human M2 and M3 receptor subtypes are 7.27?
Localization (subtypes) of M3
2) Confidence 0.47 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.44 Pain Relevance 0.08

General Comments

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