INT104342

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.18
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
dorsal horn 2
spinal 1
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 188 100.00 Very High Very High Very High
Spinal nerve ligature 173 100.00 Very High Very High Very High
Eae 14 100.00 Very High Very High Very High
Neuropathic pain 181 99.88 Very High Very High Very High
c fibre 3 99.84 Very High Very High Very High
chronic construction injury 29 99.80 Very High Very High Very High
allodynia 125 99.12 Very High Very High Very High
spinal dorsal horn 25 98.48 Very High Very High Very High
antagonist 29 98.32 Very High Very High Very High
Dorsal horn 36 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 97 100.00 Very High Very High Very High
Neuropathic Pain 319 99.88 Very High Very High Very High
Nociception 41 90.28 High High
INFLAMMATION 7 89.84 High High
Inflammatory Pain 4 86.40 High High
Nervous System Injury 63 75.00 Quite High
Hypersensitivity 8 56.24 Quite High
Neuroma 1 51.44 Quite High
Pain 53 5.00 Very Low Very Low Very Low
Ganglion Cysts 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant differences between the effect of spinal capsazepine on the non-potentiated component of the C-fibre evoked response of SNL and sham operated rats are reported (p< 0.01, two-way ANOVA).
Regulation (response) of SNL in spinal associated with c fibre
1) Confidence 0.15 Published 2002 Journal Neuroreport Section Abstract Doc Link 12151758 Disease Relevance 0.16 Pain Relevance 0.38
Besides its effect on the SNL-induced ipsilateral mechanic allodynia, c-fos ASO significantly inhibited SNL-induced Fos protein expression in the ipsilateral dorsal horn.
Regulation (effect) of SNL-induced in dorsal horn associated with allodynia, spinal nerve ligature and dorsal horn
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.94
On the other hand, we found SNL injury did not affect the number of NeuN-positive cells in spinal dorsal horn both in wild-type and Cav2.2-/- mice.
Neg (not) Regulation (affect) of SNL in dorsal horn associated with spinal dorsal horn and injury
3) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.34
To investigate whether combining NMDAR antagonist ketamine with astrocytic inhibitor LAA could exert some additive and complementary effects on SNL-induced neuropathic pain, we coadministrated ketamine (100 ?
Regulation (effects) of SNL associated with ketamine, spinal nerve ligature, antagonist and neuropathic pain
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.58 Pain Relevance 1.54
Effects of ketamine on SNL-induced NMDAR phosphorylation
Regulation (Effects) of SNL associated with ketamine and spinal nerve ligature
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.19 Pain Relevance 0.95
This is in contrast to some studies examining cold sensitivity in the SNL and CCI models or neuropathic pain [40], [49], [50].
Spec (examining) Regulation (sensitivity) of SNL associated with eae, neuropathic pain and chronic construction injury
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.30 Pain Relevance 0.69

General Comments

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