INT104348

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc, Gnrh1) extracellular space (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
neurons 4
Pnoc (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 24 100.00 Very High Very High Very High
Opioid 3 96.84 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Orphanin FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neurons.
Orphanin FQ Negative_regulation (inhibits) of Localization (secretion) of GnRH in neurons associated with orphanin
1) Confidence 0.45 Published 2002 Journal Neuroreport Section Title Doc Link 12151779 Disease Relevance 0 Pain Relevance 0.41
The studies revealed that orphanin FQ potently and dose-dependently inhibits forskolin-induced gonadotropin-releasing hormone release from rat hypothalamic fragments.
orphanin FQ Negative_regulation (inhibits) of Localization (release) of releasing hormone associated with orphanin
2) Confidence 0.34 Published 2002 Journal Neuroreport Section Abstract Doc Link 12151779 Disease Relevance 0 Pain Relevance 0.42
To test this hypothesis, we used rat hypothalamic fragments and immortalized gonadotropin-releasing hormone neurons (GT1-7) in vitro and examined whether orphanin FQ would inhibit forskolin-induced gonadotropin-releasing hormone release.
orphanin FQ Spec (whether) Negative_regulation (inhibit) of Localization (release) of releasing hormone in neurons associated with orphanin
3) Confidence 0.34 Published 2002 Journal Neuroreport Section Abstract Doc Link 12151779 Disease Relevance 0 Pain Relevance 0.41

General Comments

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