INT104356

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 6.64
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp)
Anatomy Link Frequency
Caco-2 3
nerve 2
brain 2
capillary 1
nerve trunks 1
Pgp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 164 100.00 Very High Very High Very High
depression 74 99.30 Very High Very High Very High
Morphine 9 99.04 Very High Very High Very High
Analgesic 5 98.32 Very High Very High Very High
Calcitonin gene-related peptide 5 98.16 Very High Very High Very High
opiate 1 97.92 Very High Very High Very High
addiction 1 96.88 Very High Very High Very High
lidocaine 4 96.66 Very High Very High Very High
qutenza 10 94.28 High High
Hypoesthesia 1 93.52 High High
Disease Link Frequency Relevance Heat
Pain 163 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 99.36 Very High Very High Very High
Depression 76 99.30 Very High Very High Very High
Injury 271 94.44 High High
Adhesions 5 93.88 High High
Hypesthesia 1 93.52 High High
Inflammatory Pain 6 93.16 High High
Increased Venous Pressure Under Development 3 92.48 High High
Hyperalgesia 3 88.96 High High
Coronary Artery Disease 17 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to characterize the rat jejunal passive transport and the possible active efflux of three local anaesthetics, ropivacaine, lidocaine and bupivacaine using two different absorption models, the in situ single-pass intestinal perfusion and the in vitro Ussing chamber model, as well as P-glycoprotein (Pgp)-mediated calcein transport inhibition in Caco-2 cells.
Negative_regulation (inhibition) of Pgp in Caco-2 associated with lidocaine
1) Confidence 0.43 Published 2004 Journal Eur J Pharm Sci Section Abstract Doc Link 14998587 Disease Relevance 0 Pain Relevance 0.22
Axotomized rats had near-total loss of PGP9.5(+) innervation within ipsilateral tibial-innervated skin at all time-points.
Negative_regulation (loss) of PGP9 in skin
2) Confidence 0.42 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15122703 Disease Relevance 0.47 Pain Relevance 0.09
At a predefined time a challenge has been made with a pharmacological dose with a PgP-inhibitor, allowing the tracer increase to reveal time course and magnitude of inhibition of the PgP.


Negative_regulation (inhibition) of PgP
3) Confidence 0.41 Published 2008 Journal BMC Med Phys Section Body Doc Link PMC2430701 Disease Relevance 0 Pain Relevance 0.09
Cyclosporin A-mediated inhibition of Pgp enhanced the uptake of morphine in lambda-carrageenan and control animals.
Negative_regulation (inhibition) of Pgp associated with morphine
4) Confidence 0.35 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.20 Pain Relevance 1.66
However, it remains to be seen whether the risk factors identified in the present study are of clinical value in treatment and prevention of PGP.


Spec (whether) Negative_regulation (prevention) of PGP associated with pain
5) Confidence 0.31 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890600 Disease Relevance 0.91 Pain Relevance 0.84
Specifically, it was shown in vitro that fluvoxamine induces intermediate Pgp inhibition in MDR1 cells (model for human Pgp) as well as in primary porcine brain capillary endothelial cells (model for the BBB) (15), although this could not be confirmed in another study in MDR-1 cells (16).
Negative_regulation (inhibition) of Pgp in capillary
6) Confidence 0.26 Published 2007 Journal Pharm Res Section Body Doc Link PMC2279155 Disease Relevance 0 Pain Relevance 0.09
In the paravaginal tissue, a large number of PGP-, NOS-, TH-, VIP-immunoreactive (IR) and few CGRP-IR nerve trunks were observed, giving off branches to the smooth muscle wall.
Negative_regulation (number) of PGP in nerve trunks associated with calcitonin gene-related peptide
7) Confidence 0.25 Published 2002 Journal Int. J. Impot. Res. Section Abstract Doc Link 12152117 Disease Relevance 0 Pain Relevance 0.22
Specifically, it has been shown that fluvoxamine inhibits Pgp in MDR1 cells (a model for human Pgp) as well as in primary porcine brain capillary endothelial cells (model for the blood-brain barrier) (15).
Negative_regulation (inhibits) of Pgp in brain
8) Confidence 0.23 Published 2007 Journal Pharm Res Section Body Doc Link PMC2279155 Disease Relevance 0 Pain Relevance 0.03
TSB transport from the apical (AP) to basolateral (BL) side in Caco-2 monolayers was 3.3- to 5.7-fold lower than that from BL to AP side, but this polarized transport was attenuated by co-incubation of PgP or MRP1/2 inhibitors.
Negative_regulation (inhibitors) of PgP in Caco-2
9) Confidence 0.22 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0.11 Pain Relevance 0.09
The uptake and efflux of TSB in Caco-2 cells were also significantly altered in the presence of an inhibitor for P-glycoprotein (PgP) or for multi-drug resistance associated protein (MRP1/2).
Negative_regulation (inhibitor) of PgP in Caco-2
10) Confidence 0.21 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0.14 Pain Relevance 0.11
Likewise, no indication for efflux transport of VPA was obtained in a rat microdialysis model, using inhibitors of either Pgp or MRPs.
Negative_regulation (inhibitors) of Pgp
11) Confidence 0.15 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17043155 Disease Relevance 0.17 Pain Relevance 0.06
This was closely associated with the decrease of PGP-ir intraepithelial nerve fibers.
Negative_regulation (decrease) of PGP-ir in nerve
12) Confidence 0.13 Published 2004 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 15615030 Disease Relevance 0 Pain Relevance 0.73
The western blot analysis showing progressive decrease in levels of cellular markers (CNPase, NSE and PGP9.5) up to 4 weeks is likely to reflect the clearance of non-cell associated markers.
Negative_regulation (decrease) of PGP9
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2918504 Disease Relevance 0.49 Pain Relevance 0
PGP9.5 content was also significantly reduced from about 70% of control levels at 24 hours (p<0.01) to 40% at 4 days (p<0.05) and 30% at 4 (p<0.001) and 10 weeks.


Negative_regulation (reduced) of PGP9
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2918504 Disease Relevance 0.66 Pain Relevance 0.04
Reduced potential amplitudes (electroneuromyographic data) were found to be associated with reduced PGP 9.5 (63.6%) and nerve fiber neurofilament staining (45.4%) by immunohistochemistry and with loss of myelinated fibers (100%) by semithin section analysis.
Negative_regulation (reduced) of PGP in nerve
15) Confidence 0.01 Published 2006 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 16906282 Disease Relevance 0.38 Pain Relevance 0.19
Furthermore, HPA hyperactivity during depression alters the blood brain barrier by deregulation of the multidrug resistance p-glycoprotein (MRD PGP) [30].
Negative_regulation (deregulation) of PGP in brain associated with depression and attention deficit hyperactivity disorder
16) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2994859 Disease Relevance 2.11 Pain Relevance 0.43

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