INT104387

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 22.26
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9)
Anatomy Link Frequency
spore 2
leukocytes 2
Th1 cells 2
monocyte 1
mast cells 1
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 782 100.00 Very High Very High Very High
Inflammatory mediators 16 100.00 Very High Very High Very High
rheumatoid arthritis 558 99.84 Very High Very High Very High
interstitial cystitis 164 99.84 Very High Very High Very High
Inflammation 435 99.18 Very High Very High Very High
Osteoarthritis 250 99.04 Very High Very High Very High
cytokine 245 96.04 Very High Very High Very High
Inflammatory response 36 94.16 High High
fibrosis 44 82.88 Quite High
Central nervous system 22 78.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 473 100.00 Very High Very High Very High
Injury 9 100.00 Very High Very High Very High
Rheumatoid Arthritis 558 99.84 Very High Very High Very High
Interstitial Cystitis 164 99.84 Very High Very High Very High
Sprains And Strains 243 99.64 Very High Very High Very High
Bacillus Anthracis Infection 130 99.56 Very High Very High Very High
Cystitis 280 99.44 Very High Very High Very High
Infection 591 99.12 Very High Very High Very High
Osteoarthritis 250 99.04 Very High Very High Very High
Mycobacterial Infection 151 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, mice with CYP-induced cystitis expressed higher serum CXCL10 > CXCL9 than unaffected controls, while IC patients displayed higher CXCL9 > CXCL10 serum levels than unaffected individuals.


Positive_regulation (higher) of CXCL9 associated with cystitis and interstitial cystitis
1) Confidence 0.67 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.95 Pain Relevance 0.40
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Positive_regulation (increases) of CXCL9
2) Confidence 0.67 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.24
We show that serum levels of CXCL9, CXCL10, and CXCL11 were increased in IC patients.
Positive_regulation (increased) of CXCL9 associated with interstitial cystitis
3) Confidence 0.67 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.22 Pain Relevance 0.37
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Cxcl9 associated with chemokine
4) Confidence 0.59 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.97 Pain Relevance 0.63
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Cxcl9 in immune cell associated with chemokine, injury and infection
5) Confidence 0.59 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.53 Pain Relevance 0.27
CYP-induced cystitis in mice led to substantial increases in serum levels of CXCL10 >> CXCL9 when compared with the levels in unaffected controls (Figure 1B).
Positive_regulation (increases) of CXCL9 associated with cystitis
6) Confidence 0.58 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.86 Pain Relevance 0.41
Indeed, the post-challenge induction of endogenous CXCL9, CXCL10, and CXCL11 previously associated with resistance to inhalational B. anthracis infection [22] was maintained in animals receiving CXCR3 neutralizing serum (Figure S3).
Positive_regulation (induction) of CXCL9 associated with infection
7) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.85 Pain Relevance 0.08
In the present study, we investigated the consequences of selectively neutralizing CXCL9, CXCL10, and/or CXCL11 during pulmonary B. anthracis infection, and whether potential ligand-mediated contributions to host defense were independent of interactions with CXCR3.
Positive_regulation (neutralizing) of CXCL9 associated with infection
8) Confidence 0.42 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.37 Pain Relevance 0.15
, but did not increase CXCL9 or CXCL10 mRNAs at 21 days.
Neg (not) Positive_regulation (increase) of CXCL9
9) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.37 Pain Relevance 0.13
Antimicrobial activity against B. anthracis spores during infection is consistent with the previously reported association between CXCL9, CXCL10, and CXCL11 induction and decreased spore germination in vivo [22], as well as observations that the reduction of spore burden on resident macrophages is important in preventing intracellular vegetative outgrowth and subsequent disease progression [46].
Positive_regulation (induction) of CXCL9 in spore associated with disease progression and infection
10) Confidence 0.39 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.63 Pain Relevance 0.18
CXCL9 and CXCL10 are each induced to relatively high levels within the lungs following spore challenge suggesting that antimicrobial activity may act early in infection against the spore form of the organism.
Positive_regulation (induced) of CXCL9 in spore associated with infection
11) Confidence 0.39 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.48 Pain Relevance 0.26
Importantly, the CXCR3 ligands CXCL9 and CXCL10 are also upregulated in RA.
Positive_regulation (upregulated) of CXCL9 associated with rheumatoid arthritis
12) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.31 Pain Relevance 0.70
These findings suggest that substantial expression of CXCR3 protein on mast cells within synovial tissue from RA patients plays a significant role in the pathophysiology of RA, accompanied by elevated levels of the chemokines CXCL9 and CXCL10.
Positive_regulation (elevated) of CXCL9 in mast cells associated with chemokine and rheumatoid arthritis
13) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193722 Disease Relevance 1.28 Pain Relevance 0.56
inducible chemokine receptor CXCR3 and of its ligands CXCL9 and CXCL10 are strongly upregulated in RA as compared with OA (Table 2).
Positive_regulation (upregulated) of CXCL9 associated with chemokine, rheumatoid arthritis and osteoarthritis
14) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.16 Pain Relevance 0.55
Concomitantly, significantly increased mRNA levels of CXCL9 and CXCL10 were also detected in RA synovial tissue.
Positive_regulation (increased) of CXCL9 associated with rheumatoid arthritis
15) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.29 Pain Relevance 0.72
Also, chemokine profiles in the acute phase were different, with high levels of RANTES found in mice infected either both strains, but with higher levels of cardiac MIG, MCP-1, and MIP-1?
Positive_regulation (levels) of MIG associated with chemokine and sprains and strains
16) Confidence 0.36 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.71 Pain Relevance 0.21
Capitol building during the 2001 anthrax attacks demonstrated elevated levels of several inflammatory mediators including CXCL9 [41].
Positive_regulation (elevated) of CXCL9 associated with inflammatory mediators and bacillus anthracis infection
17) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.67 Pain Relevance 0.16
CXCR3 exhibited 2.3-fold, CXCL9 4.6-fold, and CXCL10 9.8-fold increased levels in RA samples.
Positive_regulation (increased) of CXCL9 associated with rheumatoid arthritis
18) Confidence 0.33 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.20 Pain Relevance 0.58
The CXC chemokines CXCL8, CXCL9, and CXCL10, and the CC chemokines CCL2 and CCL4 could be detected in rheumatoid ST.
Positive_regulation (chemokines) of CXCL9 associated with chemokine
19) Confidence 0.32 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0 Pain Relevance 0.19
These data suggest that induction of neutrophil-associated chemokines such as CXCL9 and CXCL10 on D12–D15 may be key to accumulation of activated Th1 cells in the lung on D21.
Positive_regulation (induction) of CXCL9 in Th1 cells associated with chemokine and infection
20) Confidence 0.31 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.09 Pain Relevance 0.05

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