INT104388

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 25.68
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
macrophage 17
epithelial cells 4
neutrophils 3
liver 2
fibroblast 2
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 608 100.00 Very High Very High Very High
cytokine 257 100.00 Very High Very High Very High
Inflammatory mediators 29 100.00 Very High Very High Very High
chemokine 198 98.92 Very High Very High Very High
fibrosis 428 98.00 Very High Very High Very High
ischemia 71 95.92 Very High Very High Very High
anesthesia 24 95.32 Very High Very High Very High
Inflammatory stimuli 8 89.88 High High
Paracetamol 2 86.16 High High
cINOD 6 82.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 650 100.00 Very High Very High Very High
Cancer 104 100.00 Very High Very High Very High
Infection 53 100.00 Very High Very High Very High
Adhesions 45 100.00 Very High Very High Very High
Necrosis 35 100.00 Very High Very High Very High
Hyperoxia 17 99.98 Very High Very High Very High
Injury 509 99.70 Very High Very High Very High
Burns 17 99.56 Very High Very High Very High
Apoptosis 107 99.44 Very High Very High Very High
Bacterial Infection 7 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the main pathways include the ingestion of apoptotic cells by macrophages which lead to the production of MIP-2 which is a potent chemoattractants for neutrophils.
Positive_regulation (lead) of in macrophages Gene_expression (production) of MIP-2 in neutrophils associated with apoptosis
1) Confidence 0.66 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.53 Pain Relevance 0.27
A recent study showed that C3a (the first component of the alternative pathway) is required for the production of macrophage inflammatory factor (MIP-2/CXCL2) and keratinocyte-derived chemokine (KC/CXCL1/IL-8) by proximal tubular epithelial cells after renal ischemia/reperfusion.
Positive_regulation (required) of Gene_expression (production) of macrophage inflammatory factor in epithelial cells associated with chemokine, inflammation and ischemia
2) Confidence 0.53 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.89 Pain Relevance 0.33
Similarly to IGF-1, we found an immediate, early increase in MIP-2 mRNA expression after chemical injury, which was greater in the bevacizumab-treated than in the untreated group.
Positive_regulation (increase) of Gene_expression (expression) of MIP-2 mRNA associated with injury
3) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.61 Pain Relevance 0.12
In our model there was a successive elevation of all MIP-2 levels up to 24 hours after which the irradiated groups generally maintained their levels whilst the sham levels dropped at 48 hours. 19 Gy irradiation being significantly raised compared to sham treatment at this time point.
Positive_regulation (elevation) of Gene_expression (levels) of MIP-2
4) Confidence 0.48 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.55 Pain Relevance 0.24
The mRNA data were confirmed by ELISA analysis (Figure 5A), which also showed that the protein levels of MIP-2, KC, IL-1?
Positive_regulation (showed) of Gene_expression (levels) of MIP-2
5) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.65 Pain Relevance 0.35
The profile of induced cytokines and MIP-2 is likely to contribute to OSN apoptosis as well as accompanying rhinitis
Positive_regulation (induced) of Gene_expression (profile) of MIP-2 associated with rhinitis, apoptosis and cytokine
6) Confidence 0.42 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0.62 Pain Relevance 0.08
Similarly, mRNA levels and lung protein expression of MIP-2/CXCL2/3 were also significantly elevated with an increasing trend noted in BAL protein from dsRNA-treated lungs as compared to controls (Fig. 5B, D, and 5F).
Positive_regulation (elevated) of Gene_expression (expression) of MIP-2/CXCL2/3 in lung
7) Confidence 0.40 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.08 Pain Relevance 0.16
In ALI there is an initial accumulation of neutrophils and a later loss of adhesion of epithelial cells to the basement membrane, which induces the epithelia to express inflammatory mediators such as macrophage inflammatory protein-2 (MIP-2) and 10 kDa IFN?
Positive_regulation (induces) of Gene_expression (express) of MIP-2 in macrophage associated with inflammatory mediators, inflammation, adult respiratory distress syndrome and adhesions
8) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 2.05 Pain Relevance 0.46
We found that high-tidal-volume ventilation increased production of MIP-2 but reduced production of IP-10 (Figure 1c,d).
Positive_regulation (increased) of Gene_expression (production) of MIP-2
9) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.66 Pain Relevance 0.29
This hypothesis is supported by the data from the present study, which showed a significant increase in MIP-2 production and liver injury (as indicated by ALT and histopathology) by 6 h of reperfusion with moderate neutrophil infiltration into the ischemic liver lobe.
Positive_regulation (increase) of Gene_expression (production) of MIP-2 in liver associated with injury
10) Confidence 0.39 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.95 Pain Relevance 0.34
A recent study showed that C3a (the first component of the alternative pathway) is required for the production of macrophage inflammatory factor (MIP-2/CXCL2) and keratinocyte-derived chemokine (KC/CXCL1/IL-8) by proximal tubular epithelial cells after renal ischemia/reperfusion.
Positive_regulation (required) of Gene_expression (production) of CXCL2 in epithelial cells associated with chemokine, inflammation and ischemia
11) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.89 Pain Relevance 0.33
The prior burn injury in this model induced two-peaked production of cytokines, TNF-alpha, and macrophage inflammatory protein-2 at 2 and 12 h after LPS administration, and it was associated with increased mortality.
Positive_regulation (induced) of Gene_expression (production) of inflammatory protein-2 in macrophage associated with inflammation, burns, injury and cytokine
12) Confidence 0.38 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12388363 Disease Relevance 1.38 Pain Relevance 0.35
One study showed that following infection, both the corneal resident cells and infiltrating neutrophils produced MIP-2 and VEGF, and the significantly high levels of both genes paralleled the extensive corneal neovascularization seen at later stages of the disease.
Positive_regulation (following) of Gene_expression (produced) of MIP-2 in neutrophils associated with corneal neovascularization, disease and infection
13) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 1.22 Pain Relevance 0.09
MIP-2 expression significantly increased in both the untreated and treated mice on day 2 and then dropped to near-normal levels by day 14.
Positive_regulation (increased) of Gene_expression (expression) of MIP-2
14) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.16 Pain Relevance 0.05
In ALI there is an initial accumulation of neutrophils and a later loss of adhesion of epithelial cells to the basement membrane, which induces the epithelia to express inflammatory mediators such as macrophage inflammatory protein-2 (MIP-2) and 10 kDa IFN?
Positive_regulation (mediators) of Gene_expression (express) of MIP-2 in macrophage associated with inflammatory mediators, inflammation, adult respiratory distress syndrome and adhesions
15) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 1.98 Pain Relevance 0.43
In ALI there is an initial accumulation of neutrophils and a later loss of adhesion of epithelial cells to the basement membrane, which induces the epithelia to express inflammatory mediators such as macrophage inflammatory protein-2 (MIP-2) and 10 kDa IFN?
Positive_regulation (induces) of Gene_expression (express) of MIP-2 in macrophage associated with inflammatory mediators, inflammation, adult respiratory distress syndrome and adhesions
16) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 2.05 Pain Relevance 0.46
Increased production of MIP-2 but reduced production of IP-10 was found in mice ventilated at 30 ml/kg VT compared with control, nonventilated mice and compared with mice ventilated at 6 ml/kg VT.
Positive_regulation (Increased) of Gene_expression (production) of MIP-2
17) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.37 Pain Relevance 0.14
In our study, we found that high-tidal-volume ventilation increased epithelium–fibroblast transition, collagen accumulation, and MIP-2 production, but deceased production of IP-10.


Positive_regulation (increased) of Gene_expression (production) of MIP-2 in fibroblast
18) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.87 Pain Relevance 0.43
RESULTS: LPS induced significant increases in TNFalpha and MIP-2 production.
Positive_regulation (increases) of Gene_expression (production) of MIP-2
19) Confidence 0.26 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The data show that delta2- but not delta1-opioid agonists suppress LPS-induced p38 MAPK activation and expression of TNFalpha and MIP-2.


Positive_regulation (activation) of Gene_expression (expression) of MIP-2
20) Confidence 0.26 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0

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