INT104389

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 17.42
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9)
Anatomy Link Frequency
plasma 4
lung 4
endothelial cells 2
monocyte 2
neutrophils 2
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 274 100.00 Very High Very High Very High
Inflammation 247 100.00 Very High Very High Very High
interstitial cystitis 123 99.84 Very High Very High Very High
rheumatoid arthritis 228 99.16 Very High Very High Very High
cytokine 156 96.04 Very High Very High Very High
Arthritis 23 94.40 High High
corticosteroid 1 88.04 High High
Paracetamol 2 86.16 High High
methotrexate 1 86.04 High High
Crohn's disease 55 78.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 257 100.00 Very High Very High Very High
Cancer 151 100.00 Very High Very High Very High
Necrosis 23 100.00 Very High Very High Very High
Adhesions 14 100.00 Very High Very High Very High
Cystitis 210 99.98 Very High Very High Very High
Interstitial Cystitis 123 99.84 Very High Very High Very High
Colitis 144 99.76 Very High Very High Very High
Respiratory Syncytial Virus 109 99.72 Very High Very High Very High
Granuloma 17 99.70 Very High Very High Very High
Infection 480 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and CXCL9/MIG) to be detected at a higher level in the plasma from gastric cancer patients than in patients with non-malignant gastric conditions or with normal gastric mucosa.
Positive_regulation (level) of Gene_expression (detected) of MIG in plasma associated with malignant neoplastic disease and stomach cancer
1) Confidence 0.49 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.92 Pain Relevance 0.15
and CXCL9/MIG) to be detected at a higher level in the plasma from gastric cancer patients than in patients with non-malignant gastric conditions or with normal gastric mucosa.
Positive_regulation (level) of Gene_expression (detected) of CXCL9 in plasma associated with malignant neoplastic disease and stomach cancer
2) Confidence 0.49 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.92 Pain Relevance 0.15
In summary, mice with CYP-induced cystitis expressed higher serum CXCL10 > CXCL9 than unaffected controls, while IC patients displayed higher CXCL9 > CXCL10 serum levels than unaffected individuals.


Positive_regulation (serum) of Gene_expression (expressed) of CXCL9 associated with cystitis and interstitial cystitis
3) Confidence 0.48 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.41
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Positive_regulation (received) of Gene_expression (blockade) of CXCL9
4) Confidence 0.48 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.03 Pain Relevance 0.24
We show that serum levels of CXCL9, CXCL10, and CXCL11 were increased in IC patients.
Positive_regulation (increased) of Gene_expression (levels) of CXCL9 associated with interstitial cystitis
5) Confidence 0.45 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.22 Pain Relevance 0.37
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Cxcl9 associated with chemokine
6) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.97 Pain Relevance 0.63
Production of chemokines such as CXCL9 (monokine induced by IFN-?)
Positive_regulation (induced) of Gene_expression (Production) of CXCL9 associated with chemokine
7) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.50 Pain Relevance 0.74
The ligands of CXCR3 (CXCL9 and CXCL10) do not chemotactically attract granulocytes, but appear to promote T-cell adhesion to endothelial cells [44].
Positive_regulation (promote) of Gene_expression (ligands) of CXCL9 in endothelial cells associated with adhesions
8) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.84 Pain Relevance 0.41
In the present study, we demonstrate that the murine interferon-inducible ELR- CXC chemokines CXCL9, CXCL10, and/or CXCL11 exert direct antimicrobial effects against toxigenic, unencapsulated B. anthracis Sterne strain (pXO1+ pXO2?)
Positive_regulation (murine) of Gene_expression (/) of chemokines CXCL9 associated with chemokine and sprains and strains
9) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.71 Pain Relevance 0.21
PP and MLN DCs expressed elevated levels of CXCL9 and CXCL11, but not CXCL10, during Mycobacteria-enhanced colitis as indicated by their relative mean fluorescent intensities (Figure 5A).
Positive_regulation (elevated) of Gene_expression (expressed) of CXCL9 associated with colitis
10) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.56 Pain Relevance 0.08
In conclusion, this study demonstrates the expression of CCL2, CXCL10, CCL4, CXCL9, and CXCL8 in ST of RA patients.
Positive_regulation (demonstrates) of Gene_expression (expression) of CXCL9 associated with rheumatoid arthritis
11) Confidence 0.32 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.90 Pain Relevance 0.53
The expression of CXCR3 and its ligands (CXCL10 >> CXCL11 or CXCL9) by mucosal T cells significantly increased in mice challenged with live Mycobacteria than compared with similar mice challenged with heat-killed Mycobacteria or controls.
Positive_regulation (increased) of Gene_expression (expression) of CXCL9 in T cells
12) Confidence 0.32 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.15 Pain Relevance 0.14
Increased production of MIG after RSV infection has been documented in vitro [31] and by us in BALB/c mice[7].
Positive_regulation (Increased) of Gene_expression (production) of MIG associated with infection and respiratory syncytial virus
13) Confidence 0.28 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 1.84 Pain Relevance 0.21
Histopathological examination showed centrilobular hepatic necrosis with leukocyte infiltration and a large number of apoptotic hepatocytes 10 and 24 h after APAP challenge. mRNA expression of intercellular adhesion molecule 1, vascular cell adhesion molecule 1, interleukin (IL) 1alpha, IL-1beta, IL-6, tumor necrosis factor alpha, monocyte chemoattractant protein 1, macrophage inflammatory protein (MIP) 1alpha, MIP-2, KC, IP-10, Mig, Fas, and inducible nitric oxide synthase was enhanced in the liver of wild-type mice injected with APAP.
Positive_regulation (enhanced) of Gene_expression (expression) of Mig in monocyte associated with necrosis, inflammation, cancer, apoptosis and adhesions
14) Confidence 0.22 Published 2002 Journal FASEB J. Section Abstract Doc Link 12153990 Disease Relevance 0.98 Pain Relevance 0.21
In the mouse model of tuberculosis, depletion of neutrophils one day prior to infection did not impact overall susceptibility but had an effect on granuloma formation and resulted in delayed expression of CXCL9 [79].
Positive_regulation (resulted) of Gene_expression (expression) of CXCL9 in neutrophils associated with mycobacterial infection, granuloma and infection
15) Confidence 0.21 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.88 Pain Relevance 0.03
This hypothesis is tested by depleting neutrophils between D10–15 and we show that this results in decreased expression of CXCL9 mRNA expression and reduced accumulation of Th1 cells in the M.tuberculosis-infected lung on D21.
Positive_regulation (results) of Gene_expression (expression) of CXCL9 mRNA in lung associated with mycobacterial infection and infection
16) Confidence 0.21 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.99 Pain Relevance 0.04
This hypothesis is tested by depleting neutrophils between D10–15 and we show that this results in decreased expression of CXCL9 mRNA expression and reduced accumulation of Th1 cells in the M.tuberculosis-infected lung on D21.
Positive_regulation (results) of Gene_expression (expression) of CXCL9 mRNA in lung associated with mycobacterial infection and infection
17) Confidence 0.21 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.04 Pain Relevance 0.04

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