INT104390

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Got1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.62 Very High Very High Very High
Glutamate 2 85.04 High High
Inflammation 1 64.96 Quite High
cytokine 3 25.00 Low Low
chemokine 1 25.00 Low Low
imagery 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis 2 99.28 Very High Very High Very High
Necrosis 4 90.64 High High
Apoptosis 4 85.92 High High
Disease 20 80.56 Quite High
Adhesions 2 78.80 Quite High
Toxicity 23 76.36 Quite High
Body Weight 2 76.28 Quite High
Injury 6 75.00 Quite High
Cancer 10 71.04 Quite High
INFLAMMATION 1 64.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In wild-type BALB/c mice, i.p. administration of acetaminophen (APAP; 750 mg/kg) induced intrahepatic IFN-gamma mRNA expression and a marked increase in serum transaminase levels, leading to acute lethality of approximately 45%.
Positive_regulation (induced) of Positive_regulation (increase) of serum transaminase associated with paracetamol
1) Confidence 0.26 Published 2002 Journal FASEB J. Section Abstract Doc Link 12153990 Disease Relevance 0.61 Pain Relevance 0.21
Increasing the dose to 7mg/m2 did not increase the treatment efficacy but the incidence of transaminase and CPK elevations and serious AEs.
Neg (not) Positive_regulation (increase) of Positive_regulation (elevations) of transaminase
2) Confidence 0.04 Published 2009 Journal Marine Drugs Section Abstract Doc Link PMC2666889 Disease Relevance 0.34 Pain Relevance 0
The significant increase of GOT and GPT activities was found to be accompanied with the elevation of hepatic TBARS level, IL-18 mRNA expression and serum IL-18 concentration, and was significantly alleviated by supplementation with 6 % S. platensis in diets.
Positive_regulation (accompanied) of Positive_regulation (increase) of GOT
3) Confidence 0.02 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20102673 Disease Relevance 0.39 Pain Relevance 0.62

General Comments

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