INT104392

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 113
Total Number 129
Disease Relevance 106.86
Pain Relevance 34.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
T cell 7
monocyte 4
joints 3
spore 3
endothelial cells 3
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2255 100.00 Very High Very High Very High
chemokine 1877 100.00 Very High Very High Very High
cytokine 1341 100.00 Very High Very High Very High
Inflammatory response 220 100.00 Very High Very High Very High
Inflammatory mediators 67 100.00 Very High Very High Very High
Inflammatory stimuli 18 100.00 Very High Very High Very High
interstitial cystitis 1069 99.84 Very High Very High Very High
rheumatoid arthritis 776 99.84 Very High Very High Very High
Sciatic nerve 3 99.84 Very High Very High Very High
Lasting pain 26 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2411 100.00 Very High Very High Very High
Cancer 1672 100.00 Very High Very High Very High
Adhesions 104 100.00 Very High Very High Very High
Necrosis 93 100.00 Very High Very High Very High
Cystitis 1821 99.98 Very High Very High Very High
Interstitial Cystitis 1069 99.84 Very High Very High Very High
Rheumatoid Arthritis 781 99.84 Very High Very High Very High
Sprains And Strains 306 99.82 Very High Very High Very High
Colitis 975 99.76 Very High Very High Very High
Pain 95 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CSF-1 induced expression of the proatherogenic chemokines CXCL10/IP-10, CCL2 and CCL7 but repressed expression of the antiatherogenic chemokine receptor CXCR4 [53].
Gene_expression (expression) of CXCL10 associated with chemokine
1) Confidence 0.75 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.78 Pain Relevance 0.27
, CXCL1, CXCL5/ENA78, CXCL8/IL8, CXCL9/MIG, CXCL10/IP10) were found to be overexpressed in the tumours while CCL15/MIP-1?
Gene_expression (overexpressed) of CXCL10 associated with cancer
2) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.28 Pain Relevance 0.05
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Gene_expression (expression) of Cxcl10 in retinas
3) Confidence 0.75 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.97 Pain Relevance 0.35
In summary, mice with CYP-induced cystitis expressed higher serum CXCL10 > CXCL9 than unaffected controls, while IC patients displayed higher CXCL9 > CXCL10 serum levels than unaffected individuals.


Gene_expression (expressed) of CXCL10 associated with cystitis and interstitial cystitis
4) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.41
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Gene_expression (expression) of CXCL10 in T cell
5) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.24 Pain Relevance 0.37
is a potent inducer of CXCL10 expression by endothelial cells [60]; this inflammatory cytokine was negatively modulated by CXCL10 blockade during CYP-induced cystitis.
Gene_expression (expression) of CXCL10 in endothelial cells associated with inflammation, cystitis and cytokine
6) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.72 Pain Relevance 0.41
To this end, CXCR3 expression and CXCL10-signaling by sensory neurons correlate with the maintenance phase of persistent pain [19].
Gene_expression (expression) of CXCL10-signaling in sensory neurons associated with pain and lasting pain
7) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.61 Pain Relevance 0.56
Serum CXCL9, CXCL10, and CXCL11 levels of CYP-treated mice given control Ab were compared to similar mice that received anti-CXCL10 Ab.
Gene_expression (levels) of CXCL10
8) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.36 Pain Relevance 0.45
Taken together, the higher expression of CXCL9 in man and CXCL10 in mouse, during clinical and experimental disease, respectively, could be explained by these promoter differences or the imperfect correlation between clinical disease and the experimental mouse model used in this study.
Gene_expression (expression) of CXCL10 associated with disease
9) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.07 Pain Relevance 0.52
CXCL10 expression has also been shown to be elevated in bladders following cancer therapy and febrile urinary infection [20,21].
Gene_expression (expression) of CXCL10 in bladders associated with cancer, fever and infection
10) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.65 Pain Relevance 0.54
CD4+ T cell infiltration and expression of CXCL10 is seen in many mucosal inflammatory diseases [30-43].
Gene_expression (expression) of CXCL10 in T cell associated with inflammation and disease
11) Confidence 0.73 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.95 Pain Relevance 0.38
This notion is supported by the ability of epithelial [38], [39] and mononuclear cells [5] to produce significant amounts of CXCL9, CXCL10, and/or CXCL11 in response to inflammatory stimuli, with concentrations of CXCL9 and CXCL10 reaching several hundred nanograms per milliliter [39].
Gene_expression (produce) of CXCL10 in mononuclear cells associated with inflammatory stimuli
12) Confidence 0.70 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.67 Pain Relevance 0.31
Sulindac, but not aspirin or sodium salicylate, inhibited IFNgamma-induced expression of the CXC ligand 9 (CXCL9) mRNA, a chemokine for activated T cells, whereas the interferon-induced expression of CXCL10 or IFN regulatory factor-1 was not affected by sulindac.
Gene_expression (expression) of CXCL10 in T cells associated with chemokine and aspirin
13) Confidence 0.67 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.31 Pain Relevance 0.25
In animal studies, expression levels of the MIP-2 and IP-10 are inversely correlated with the degree of lung damage, with the extent of neovascularization, and with fibrogenesis in bleomycin-treated samples [11].
Gene_expression (expression) of IP-10 in lung associated with fibrosis
14) Confidence 0.66 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 1.57 Pain Relevance 0.50
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL10
15) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.70 Pain Relevance 0
The following genes (CXCL5/ENA-78, CXCL8/IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL10
16) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.40 Pain Relevance 0
In contrast, EpCAM, IL8, CXCL10/IP10, CCL3/MIP-1?
Gene_expression (/) of CXCL10
17) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.05 Pain Relevance 0.15
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL10
18) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.86 Pain Relevance 0.15
EpCAM, IL8, CXCL10/IP10, CCL3/MIP-1?
Gene_expression (/) of CXCL10
19) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.31 Pain Relevance 0.18
is a potent inducer of CXCL10 expression by endothelial cells [60]; this inflammatory cytokine was negatively modulated by CXCL10 blockade during CYP-induced cystitis.
Gene_expression (blockade) of CXCL10 in endothelial cells associated with inflammation, cystitis and cytokine
20) Confidence 0.63 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.60 Pain Relevance 0.43

General Comments

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