INT104394

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 25.64
Pain Relevance 8.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
Th1 cells 4
endothelial cells 4
astrocyte 4
T cell 4
macrophages 3
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 441 100.00 Very High Very High Very High
chemokine 371 100.00 Very High Very High Very High
Sciatic nerve 2 99.84 Very High Very High Very High
Lasting pain 8 99.72 Very High Very High Very High
cytokine 268 99.52 Very High Very High Very High
rheumatoid arthritis 126 98.64 Very High Very High Very High
interstitial cystitis 328 98.36 Very High Very High Very High
Neuritis 9 94.48 High High
Arthritis 18 94.40 High High
corticosteroid 1 88.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 452 100.00 Very High Very High Very High
Cancer 31 100.00 Very High Very High Very High
Adhesions 29 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Cystitis 560 99.98 Very High Very High Very High
Colitis 173 99.76 Very High Very High Very High
Pain 21 99.72 Very High Very High Very High
Infection 396 99.16 Very High Very High Very High
Oral Lichen Planus 8 99.00 Very High Very High Very High
Apoptosis 137 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL10 expression has also been shown to be elevated in bladders following cancer therapy and febrile urinary infection [20,21].
Positive_regulation (elevated) of Gene_expression (expression) of CXCL10 in bladders associated with cancer, fever and infection
1) Confidence 0.65 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.67 Pain Relevance 0.54
In summary, mice with CYP-induced cystitis expressed higher serum CXCL10 > CXCL9 than unaffected controls, while IC patients displayed higher CXCL9 > CXCL10 serum levels than unaffected individuals.


Positive_regulation (serum) of Gene_expression (expressed) of CXCL10 associated with cystitis and interstitial cystitis
2) Confidence 0.47 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.41
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Positive_regulation (received) of Gene_expression (blockade) of CXCL10
3) Confidence 0.47 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.23
In addition, a number of studies have also reported an increased expression of CXCL10 in the serum and mucosa of patients with UC [29,39,40].
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 associated with inflammatory bowel disease
4) Confidence 0.46 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.33 Pain Relevance 0.08
The expression of CXCR3 and its ligands (CXCL10 >> CXCL11 or CXCL9) by mucosal T cells significantly increased in mice challenged with live Mycobacteria than compared with similar mice challenged with heat-killed Mycobacteria or controls.
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 in T cells
5) Confidence 0.46 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.15 Pain Relevance 0.14
In the present study, we demonstrate that the murine interferon-inducible ELR- CXC chemokines CXCL9, CXCL10, and/or CXCL11 exert direct antimicrobial effects against toxigenic, unencapsulated B. anthracis Sterne strain (pXO1+ pXO2?)
Positive_regulation (murine) of Gene_expression (/) of CXCL10 associated with chemokine and sprains and strains
6) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.71 Pain Relevance 0.21
Environmental (e.g., acrolein) or pathogenic (e.g., Escherichia coli) insults induce epithelial cells to increase their expression of CXCL10 [55], suggesting the mucosa participates in modulating T cell-mediated inflammation via CXCR3-CXCR3 ligand interactions.
Positive_regulation (increase) of Gene_expression (expression) of CXCL10 in T cell associated with inflammation
7) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.28 Pain Relevance 0.19
Taken together, the higher expression of CXCL9 in man and CXCL10 in mouse, during clinical and experimental disease, respectively, could be explained by these promoter differences or the imperfect correlation between clinical disease and the experimental mouse model used in this study.
Positive_regulation (higher) of Gene_expression (expression) of CXCL10 associated with disease
8) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.07 Pain Relevance 0.52
The expression of CXCL9, CXCL10, and CXCL11 can be induced by IFN-?
Positive_regulation (induced) of Gene_expression (expression) of CXCL10
9) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.55 Pain Relevance 0.18
is a potent inducer of CXCL10 expression by endothelial cells [60]; this inflammatory cytokine was negatively modulated by CXCL10 blockade during CYP-induced cystitis.
Positive_regulation (inducer) of Gene_expression (expression) of CXCL10 in endothelial cells associated with inflammation, cystitis and cytokine
10) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.72 Pain Relevance 0.42
The ability of CXCL10 blockade to modulate local chemokines as well as Th1 cytokine mRNA expression and to facilitate the decline of serum levels of CXCL9 and CXCL10 is an indication of reduced local as well as systemic inflammation.
Positive_regulation (facilitate) of Gene_expression (levels) of CXCL10 associated with chemokine, inflammation and cytokine
11) Confidence 0.44 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.75 Pain Relevance 0.37
Our data show that vault immunization results in the production of factors associated with increased lymphocyte recruitment such as CXCL10 production.
Positive_regulation (increased) of Gene_expression (production) of CXCL10 in lymphocyte associated with immunization
12) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.76 Pain Relevance 0.11
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Cxcl10 associated with chemokine
13) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.91 Pain Relevance 0.63
This resulted in antifibrogenic signals, including growth inhibition but also the increased expression of the IFN-inducible chemokine CXCL10.
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 associated with chemokine
14) Confidence 0.40 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.46 Pain Relevance 0.24
The ligands of CXCR3 (CXCL9 and CXCL10) do not chemotactically attract granulocytes, but appear to promote T-cell adhesion to endothelial cells [44].
Positive_regulation (promote) of Gene_expression (ligands) of CXCL10 in endothelial cells associated with adhesions
15) Confidence 0.38 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.84 Pain Relevance 0.41
+ NK and NKT cells express CXCL10 to recruit and activate CXCR3+ leukocytes to inductive and effector sites during Mycobacteria-enhanced colitis (Figure 8).
Positive_regulation (activate) of Gene_expression (express) of CXCL10 in leukocytes associated with colitis
16) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.80 Pain Relevance 0.04
Moreover, the expression of IP-10 and MCP-1 genes in KT5, an astrocyte cell line, was induced in vitro upon stimulation with a crude antigen of malaria parasites [12].
Positive_regulation (induced) of Gene_expression (expression) of IP-10 in astrocyte associated with malaria
17) Confidence 0.32 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.27 Pain Relevance 0.30
The expression of chemokine, IP-10 and MCP-1, genes in KT-5, an astrocyte cell line, have been shown to be upregulated in vitro upon stimulation with a crude antigen of malaria parasites [12].
Positive_regulation (upregulated) of Gene_expression (expression) of IP-10 in astrocyte associated with malaria and chemokine
18) Confidence 0.32 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.47 Pain Relevance 0.35
In addition, MOMP-vaults also significantly increased levels of CXCL10, a chemokine important for attracting Th1 cells (Fig. 3c).
Positive_regulation (increased) of Gene_expression (levels) of CXCL10 in Th1 cells associated with chemokine
19) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.18 Pain Relevance 0.30
This resulted in antifibrogenic signals, including growth inhibition but also the increased expression of the IFN-inducible chemokine CXCL10.
Positive_regulation (increased) of Gene_expression (expression) of CXCL10 associated with chemokine
20) Confidence 0.29 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.46 Pain Relevance 0.24

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