INT104395

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 83
Total Number 87
Disease Relevance 73.10
Pain Relevance 19.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9)
Anatomy Link Frequency
T cells 6
plasma 5
joints 3
lung 3
spore 3
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1570 100.00 Very High Very High Very High
Inflammation 1038 100.00 Very High Very High Very High
Inflammatory stimuli 8 100.00 Very High Very High Very High
rheumatoid arthritis 712 99.92 Very High Very High Very High
interstitial cystitis 615 99.68 Very High Very High Very High
Central nervous system 89 99.68 Very High Very High Very High
cytokine 778 99.24 Very High Very High Very High
cINOD 10 99.04 Very High Very High Very High
aspirin 3 99.00 Very High Very High Very High
agonist 54 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 1417 100.00 Very High Very High Very High
Cancer 1281 100.00 Very High Very High Very High
INFLAMMATION 1116 100.00 Very High Very High Very High
Respiratory Syncytial Virus 347 100.00 Very High Very High Very High
Necrosis 64 100.00 Very High Very High Very High
Adhesions 46 100.00 Very High Very High Very High
Cystitis 1050 99.98 Very High Very High Very High
Rheumatoid Arthritis 713 99.92 Very High Very High Very High
Airway Obstruction 69 99.80 Very High Very High Very High
Colitis 720 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac, a nonsteroidal anti-inflammatory drug, selectively inhibits interferon-gamma-induced expression of the chemokine CXCL9 gene in mouse macrophages.
Gene_expression (expression) of CXCL9 in macrophages associated with chemokine, inflammation and cinod
1) Confidence 0.76 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17010317 Disease Relevance 0.39 Pain Relevance 0.28
In addition, median plasma levels of IL8, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (levels) of MIG in plasma
2) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.83 Pain Relevance 0
and CXCL9/MIG) to be detected at a higher level in the plasma from gastric cancer patients than in patients with non-malignant gastric conditions or with normal gastric mucosa.
Gene_expression (detected) of MIG in plasma associated with malignant neoplastic disease and stomach cancer
3) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.92 Pain Relevance 0.15
, CXCL1, CXCL5/ENA78, CXCL8/IL8, CXCL9/MIG, CXCL10/IP10) were found to be overexpressed in the tumours while CCL15/MIP-1?
Gene_expression (overexpressed) of CXCL9 associated with cancer
4) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.29 Pain Relevance 0.05
In addition, median plasma levels of IL8, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (levels) of CXCL9 in plasma
5) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.83 Pain Relevance 0
, CXCL1, CXCL5/ENA78, CXCL8/IL8, CXCL9/MIG, CXCL10/IP10) were found to be overexpressed in the tumours while CCL15/MIP-1?
Gene_expression (overexpressed) of MIG associated with cancer
6) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.28 Pain Relevance 0.05
and CXCL9/MIG) to be detected at a higher level in the plasma from gastric cancer patients than in patients with non-malignant gastric conditions or with normal gastric mucosa.
Gene_expression (detected) of CXCL9 in plasma associated with malignant neoplastic disease and stomach cancer
7) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.92 Pain Relevance 0.15
In summary, mice with CYP-induced cystitis expressed higher serum CXCL10 > CXCL9 than unaffected controls, while IC patients displayed higher CXCL9 > CXCL10 serum levels than unaffected individuals.


Gene_expression (expressed) of CXCL9 associated with cystitis and interstitial cystitis
8) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.96 Pain Relevance 0.41
Taken together, the higher expression of CXCL9 in man and CXCL10 in mouse, during clinical and experimental disease, respectively, could be explained by these promoter differences or the imperfect correlation between clinical disease and the experimental mouse model used in this study.
Gene_expression (expression) of CXCL9 associated with disease
9) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.07 Pain Relevance 0.51
Serum CXCL9, CXCL10, and CXCL11 levels of CYP-treated mice given control Ab were compared to similar mice that received anti-CXCL10 Ab.
Gene_expression (levels) of CXCL9
10) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.37 Pain Relevance 0.45
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Gene_expression (expression) of CXCL9 in T cell
11) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.24 Pain Relevance 0.37
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (levels) of MIG
12) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.71 Pain Relevance 0
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of MIG
13) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.86 Pain Relevance 0.15
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL9
14) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.86 Pain Relevance 0.15
The following genes (CXCL5/ENA-78, CXCL8/IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL9
15) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.41 Pain Relevance 0
IL8, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of MIG
16) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.03 Pain Relevance 0.08
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (levels) of MIG
17) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.92 Pain Relevance 0.15
IL8, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of CXCL9
18) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.03 Pain Relevance 0.08
IL8, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of MIG
19) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.03 Pain Relevance 0.08
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of MIG
20) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.65 Pain Relevance 0

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