INT1044

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 4
Speculated 8
Reported most in Abstract
Documents 358
Total Number 367
Disease Relevance 25.95
Pain Relevance 151.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 35
hypothalamus 27
neurons 19
plasma 16
MPOA 13
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 952 100.00 Very High Very High Very High
antagonist 536 100.00 Very High Very High Very High
opiate 373 100.00 Very High Very High Very High
Opioid 269 100.00 Very High Very High Very High
Morphine 170 100.00 Very High Very High Very High
gABA 145 100.00 Very High Very High Very High
Dynorphin 48 100.00 Very High Very High Very High
Hippocampus 33 100.00 Very High Very High Very High
agonist 354 99.98 Very High Very High Very High
Nicotine 78 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 452 100.00 Very High Very High Very High
Hypoglycemia 56 100.00 Very High Very High Very High
Galactorrhea 67 99.98 Very High Very High Very High
Anovulation 3 99.92 Very High Very High Very High
Diabetes Mellitus 14 99.84 Very High Very High Very High
Urological Neuroanatomy 58 99.68 Very High Very High Very High
Body Weight 40 99.10 Very High Very High Very High
Hemorrhage 13 99.04 Very High Very High Very High
Aids-related Complex 6 97.70 Very High Very High Very High
INFLAMMATION 152 96.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of these antagonists resulted in suppression of the acute release of LH and T secretion in nalmefene-treated but not in naloxone-injected animals.
Negative_regulation (suppression) of Localization (release) of LH associated with antagonist and narcan
1) Confidence 0.59 Published 1985 Journal Steroids Section Abstract Doc Link 3842024 Disease Relevance 0 Pain Relevance 0.66
Involvement of ovarian steroids and endogenous opioids in the fasting-induced suppression of pulsatile LH release in ovariectomized rats.
Negative_regulation (suppression) of Localization (release) of LH associated with narcan and endogenous opioid
2) Confidence 0.59 Published 1991 Journal J. Endocrinol. Section Title Doc Link 2066689 Disease Relevance 0.07 Pain Relevance 0.50
The participation of the ovarian steroids and opioid peptides in the suppression of pulsatile LH release during acute fasting was examined in rats.
Negative_regulation (suppression) of Localization (release) of LH associated with opioid
3) Confidence 0.59 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.05 Pain Relevance 0.23
These experiments indicate that the suppression of pulsatile LH release after 48 h of fasting is dependent upon oestradiol and that endogenous opioids are involved in the suppression.
Negative_regulation (suppression) of Localization (release) of LH associated with endogenous opioid
4) Confidence 0.59 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.09 Pain Relevance 0.50
Naloxone was able to counteract inhibition of pulsatile LH release by these steroids.
Negative_regulation (inhibition) of Localization (release) of LH associated with narcan
5) Confidence 0.59 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6122171 Disease Relevance 0 Pain Relevance 0.58
Pulsatile LH release was suppressed by estradiol benzoate or the combination of estradiol benzoate and progesterone.
Negative_regulation (suppressed) of Localization (release) of LH
6) Confidence 0.59 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6122171 Disease Relevance 0 Pain Relevance 0.57
Morphine had no effect on steroid inhibition of pulsatile LH release.
Negative_regulation (inhibition) of Localization (release) of LH associated with morphine
7) Confidence 0.59 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6122171 Disease Relevance 0 Pain Relevance 0.56
The experiments indicate that both pulsatile LH secretion, and LH release caused by VNAT stimulation, are impaired by an acute fast.
Negative_regulation (impaired) of Localization (release) of LH
8) Confidence 0.59 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 4039350 Disease Relevance 0 Pain Relevance 0.33
Pretreatment with reserpine (10 mg/kg), given 24 h before the experiment, significantly suppressed pulsatile LH secretion in these rats.
Negative_regulation (suppressed) of Localization (secretion) of LH
9) Confidence 0.59 Published 1981 Journal Endocrinology Section Abstract Doc Link 6258902 Disease Relevance 0 Pain Relevance 0.22
Pulsatile LH release was suppressed after 48 h of fasting in the ovariectomized rats implanted with oestradiol but not in the oil-implanted controls.
Negative_regulation (suppressed) of Localization (release) of LH
10) Confidence 0.59 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.07 Pain Relevance 0.36
In the fasted oestradiol-treated ovariectomized rats, naloxone was able to prevent the suppression of pulsatile LH release.
Negative_regulation (suppression) of Localization (release) of LH associated with narcan
11) Confidence 0.59 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 2066689 Disease Relevance 0.09 Pain Relevance 0.51
PBTL administration initially inhibited pulsatile LH release for 1 1/2-1 1/2 h, after which episodic release resumed.
Negative_regulation (inhibited) of Localization (release) of LH
12) Confidence 0.59 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 732952 Disease Relevance 0 Pain Relevance 0.31
However, in a subsequent study, the inhibition of pulsatile LH secretion by a 120-h fast was prevented in a group of eight rats given the opioid antagonist naloxone hydrochloride before the start of the blood-sampling period.
Negative_regulation (inhibition) of Localization (secretion) of LH in blood associated with antagonist, narcan and opioid
13) Confidence 0.59 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 4039350 Disease Relevance 0 Pain Relevance 0.44
The experiments indicate that both pulsatile LH secretion, and LH release caused by VNAT stimulation, are impaired by an acute fast.
Negative_regulation (impaired) of Localization (secretion) of LH
14) Confidence 0.59 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 4039350 Disease Relevance 0 Pain Relevance 0.36
Fasting impairs LH secretion in female rats by activating an inhibitory opioid pathway.
Negative_regulation (impairs) of Localization (secretion) of LH associated with narcan and opioid
15) Confidence 0.59 Published 1985 Journal J. Endocrinol. Section Title Doc Link 4039350 Disease Relevance 0 Pain Relevance 0.45
Hence, the inhibitory effect of naltrexone on LH release appeared to result from an alteration of the central mechanism responsible for EB-induced LH secretion.
Negative_regulation (effect) of Localization (release) of LH
16) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.70
This attenuation of opiate-induced inhibition of LH release may provide a neurochemical basis for the well-described shift in sensitivity of gonadal steroid feedback which occurs with the approach of puberty.
Negative_regulation (inhibition) of Localization (release) of LH in gonadal associated with opiate
17) Confidence 0.59 Published 1982 Journal Endocrinology Section Abstract Doc Link 7056220 Disease Relevance 0 Pain Relevance 0.29
Similarly, by 7 days in the male, and 21 days in the female, FK 33-824 is unable to inhibit LH secretion.
Negative_regulation (inhibit) of Localization (secretion) of LH
18) Confidence 0.59 Published 1983 Journal Endocrinology Section Abstract Doc Link 6291922 Disease Relevance 0 Pain Relevance 0.39
A puberty-related attenuation of opiate peptide-induced inhibition of LH secretion.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with enkephalin and opiate
19) Confidence 0.59 Published 1982 Journal Endocrinology Section Title Doc Link 7056220 Disease Relevance 0 Pain Relevance 0.42
We have observed an age-related decrease in the ability of FK to reduce LH secretion in the 48 h post-gonadectomized rat.
Negative_regulation (reduce) of Localization (secretion) of LH
20) Confidence 0.59 Published 1982 Journal Endocrinology Section Abstract Doc Link 7056220 Disease Relevance 0 Pain Relevance 0.29

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