INT104402

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.77
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
MCF-7 1
lung 1
BT-474 1
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 97.60 Very High Very High Very High
qutenza 140 93.28 High High
agonist 39 92.24 High High
palliative 1 84.24 Quite High
anesthesia 3 82.72 Quite High
antagonist 33 76.72 Quite High
Pain 6 75.64 Quite High
backache 1 75.44 Quite High
Kinase C 1 71.60 Quite High
cINOD 24 61.00 Quite High
Disease Link Frequency Relevance Heat
Epstein-barr Virus 2 99.84 Very High Very High Very High
Hyperplasia 11 99.82 Very High Very High Very High
Repression 1 99.80 Very High Very High Very High
Death 73 99.20 Very High Very High Very High
Apoptosis 414 99.10 Very High Very High Very High
Breast Cancer 144 98.96 Very High Very High Very High
Cancer 458 98.68 Very High Very High Very High
Lung Cancer 26 98.64 Very High Very High Very High
Reprotox - General 1 14 98.32 Very High Very High Very High
Malignant Neoplastic Disease 17 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other contributing effects of morphine include activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1.
Positive_regulation (increasing) of cyclin D1 associated with apoptosis and morphine
1) Confidence 0.70 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154060 Disease Relevance 0.60 Pain Relevance 0.58
The tumor cells were positive for vimentin and cytokeratins, and showed an accumulation of p53 and cyclin D1.
Positive_regulation (accumulation) of cyclin D1 associated with cancer
2) Confidence 0.44 Published 2003 Journal Pathol. Int. Section Abstract Doc Link 14516322 Disease Relevance 1.50 Pain Relevance 0.06
Western blot analysis of sensitive and resistant LDC clonal lines confirmed increases in cyclin D1, STAT6, Bcl-xL, and BAD, with decreased expression of caspase 1.
Positive_regulation (increases) of cyclin D1
3) Confidence 0.41 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.10 Pain Relevance 0.06
Western blot analysis showed a decrease in cyclin D1 and an increase in p21 and p27, indicating that the mechanism of this growth inhibition is cell cycle arrest.
Positive_regulation (increase) of cyclin D1
4) Confidence 0.32 Published 2007 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17874277 Disease Relevance 1.14 Pain Relevance 0.08
On immunohistochemistry they were found to be positive for Bcl2, CD20, CD45RB and CD79a, but negative for CD3, CD5, CD10 and cyclin D1.
Positive_regulation (negative) of cyclin D1
5) Confidence 0.30 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 18324920 Disease Relevance 0.59 Pain Relevance 0.23
Interestingly, the estrogen-stimulated induction of the cyclin D1 mRNA level was decreased by decursin only at the 3 hour timepoint.
Positive_regulation (induction) of cyclin D1 mRNA
6) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.07 Pain Relevance 0
Because cells begin to undergo cell division through mitogenic stimuli, there is induction of synthesis of cyclin D1, which is associated with the kinases CDK4 as well as CDK6.
Positive_regulation (induction) of cyclin D1
7) Confidence 0.16 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.68 Pain Relevance 0.07
The drug potently inhibited growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, which was associated with G(0)/G(1) cell-cycle arrest, increased levels of apoptosis and reduced protein expression of human epidermal growth factor receptor (EGFR), HER-2, activated extracellular-regulated kinase (ERK) and cyclin D1.
Positive_regulation (activated) of cyclin D1 in BT-474 associated with breast cancer and apoptosis
8) Confidence 0.15 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.82 Pain Relevance 0.38
activation of cyclin D1 and repression of critical genes involved in apoptosis.
Positive_regulation (activation) of cyclin D1 associated with repression and apoptosis
9) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.22 Pain Relevance 0.09
If phosphorylation occurs on T157 and T198 by PI3K (phosphoinositide 3-kinase), it triggers cell cycle transition by stabilizing the cyclin D1/cdk4 complex [55].
Positive_regulation (stabilizing) of cyclin D1
10) Confidence 0.12 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.84 Pain Relevance 0
Many of these defects are similar to those seen in the earliest lesions of breast malignancy, and Crawford and coworkers have already described this variant HMEC population to contain cells with hypermethylated INK4a promoter sequences, which leads to loss of p16INK4A protein and allows increased cell cycling through cyclin D1.
Positive_regulation (increased) of cyclin D1 associated with malignant neoplastic disease
11) Confidence 0.12 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 0.33 Pain Relevance 0
Data obtained from microarrays, tissue samples from lung cancer patients and human lung cancer cell lines indicate that cell cycle regulatory molecules, like E2F1–5, p130, Skp2, cyclin D1 and p16, contribute to the growth and progression of lung tumors [33].
Positive_regulation (contribute) of cyclin D1 in lung associated with lung cancer
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.60 Pain Relevance 0.45
The biological plausibility of this excess energy hypothesis has been supported by a number of in vitro studies: Yamamoto et al. found that increasing glucose concentration in the culture media of MCF-7 breast cancer cells increased proliferation [30], mediated by an upregulation of cdk2 and cyclin D1 [31].
Positive_regulation (upregulation) of cyclin D1 in MCF-7 associated with breast cancer
13) Confidence 0.10 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 0.94 Pain Relevance 0
Among the upregulated genes, cell growth regulatory genes were often observed (49%), including cyclin E2, replication factor C, cyclin D1, replication protein A2, and cell division cycle associated 7.
Positive_regulation (upregulated) of cyclin D1
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.84 Pain Relevance 0
B p50 and p52 homodimers from a repressive to an active state leading to cellular proliferation through activation of the cyclin D1 gene [10].
Positive_regulation (activation) of cyclin D1 gene associated with hyperplasia
15) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.51 Pain Relevance 0.06

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