INT10443

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.96
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
striatum 2
basal ganglia 2
T-lymphocytes 2
intestine 2
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 53 100.00 Very High Very High Very High
Cannabinoid receptor 46 100.00 Very High Very High Very High
agonist 29 99.52 Very High Very High Very High
mu opioid receptor 6 98.96 Very High Very High Very High
gABA 36 98.48 Very High Very High Very High
Endocannabinoid 58 98.06 Very High Very High Very High
narcan 2 97.40 Very High Very High Very High
antagonist 21 97.04 Very High Very High Very High
Opioid 1 96.60 Very High Very High Very High
Glutamate 1 91.84 High High
Disease Link Frequency Relevance Heat
Cancer 120 100.00 Very High Very High Very High
Sepsis 10 100.00 Very High Very High Very High
Ileus 4 100.00 Very High Very High Very High
Lifespan 27 99.52 Very High Very High Very High
Disease 131 98.52 Very High Very High Very High
Inflammatory Bowel Disease 27 94.12 High High
Aging 18 93.24 High High
Prostate Cancer 72 88.24 High High
Malignant Neoplastic Disease 16 86.32 High High
INFLAMMATION 23 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the attempt to shed some light on such immunomodulatory activity of AEA, we first collected evidence for the alteration of the expression of CB1R and CB2R, as a result of cell activation.
Regulation (alteration) of Gene_expression (expression) of CB1R
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.08 Pain Relevance 0.14
CB1 expression did not change in acute samples at any clinic score.
Neg (not) Regulation (change) of Gene_expression (expression) of CB1
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.58 Pain Relevance 0.03
Expression of the human cannabinoid CB1 receptor in these cells from the inducible Flp-In T-REx locus did not alter expression levels of the mu opioid receptor.
Neg (not) Regulation (alter) of Gene_expression (Expression) of CB1 associated with cannabinoid and mu opioid receptor
3) Confidence 0.45 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.73
In contrast to the situation for Jurkat cells and T-lymphocytes, the expression of CB1 in LNCaP cells was not regulated by IL-4: the relative expression of CB1/GAPDH (% of untreated controls, means ± s.e.m., n?
Regulation (relative) of Gene_expression (expression) of CB1 in T-lymphocytes
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.37 Pain Relevance 0
Thus, changes in cannabinoid receptor gene expression appear to be partially responsible for age-related loss of these receptors.
Regulation (changes) of Gene_expression (expression) of cannabinoid receptor gene associated with cannabinoid receptor
5) Confidence 0.25 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1491804 Disease Relevance 0.09 Pain Relevance 0.26
Herein, we demonstrate that CB1 expression and signaling are perturbed under these conditions.
Regulation (perturbed) of Gene_expression (expression) of CB1 associated with cannabinoid receptor
6) Confidence 0.24 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16412482 Disease Relevance 0 Pain Relevance 0.57
CB1 is a pre-synaptic receptor involved in modulating GABA release (Hajos and Freund, 2002); over the lifespan there were significant changes in the expression of CB1 in human V1 (p <?
Regulation (changes) of Gene_expression (expression) of CB1 associated with gaba, cannabinoid receptor and lifespan
7) Confidence 0.21 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.47 Pain Relevance 0.45
Given the local protective role of endocannabinoids in the prostate (see above), this study raises the possibility that differences in the relative expression of CB1 receptors and pEGFR in the tumour tissue may affect the pathogenesis and outcome of the disease.
Spec (may) Regulation (affect) of Gene_expression (expression) of CB1 associated with endocannabinoid, cancer and disease
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 1.16 Pain Relevance 0.17
The influence of adrenalectomy on cannabinoid receptor gene expression in the adult rat dorsal striatum was investigated by in situ hybridization with specific oligonucleotide probes.
Regulation (influence) of Gene_expression (expression) of cannabinoid receptor gene in striatum associated with cannabinoid receptor
9) Confidence 0.12 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8414189 Disease Relevance 0 Pain Relevance 0.16
Further, Mn exposure had no effect on D1R or cannabinoid receptor 1 levels in the basal ganglia.
Neg (no) Regulation (effect) of Gene_expression (levels) of cannabinoid receptor 1 in basal ganglia associated with cannabinoid receptor
10) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.15 Pain Relevance 0.24
Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of cannabinoid receptor in intestine associated with ileus, cannabinoid receptor and sepsis
11) Confidence 0.01 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.06 Pain Relevance 0.30

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