INT10444

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 8.69
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
N18TG2 4
T-lymphocytes 4
HEK 2
hippocampus 2
intestine 2
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 153 100.00 Very High Very High Very High
Cannabinoid receptor 96 100.00 Very High Very High Very High
qutenza 7 100.00 Very High Very High Very High
Endocannabinoid 173 99.84 Very High Very High Very High
Hippocampus 9 99.44 Very High Very High Very High
Neurotransmitter 23 99.24 Very High Very High Very High
antagonist 50 98.88 Very High Very High Very High
Pain 34 98.44 Very High Very High Very High
agonist 32 98.42 Very High Very High Very High
headache 6 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 10 100.00 Very High Very High Very High
Ileus 4 100.00 Very High Very High Very High
Inflammatory Bowel Disease 96 99.60 Very High Very High Very High
Neuroblastoma 4 99.28 Very High Very High Very High
Colitis 60 99.08 Very High Very High Very High
Pain 44 98.44 Very High Very High Very High
Prostate Cancer 174 98.20 Very High Very High Very High
Anaplastic Astrocytoma 7 97.52 Very High Very High Very High
Migraine Disorders 3 97.40 Very High Very High Very High
Vomiting 267 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of expression of the modified cannabinoid CB1 receptor did not limit DAMGO-mediated ERK1/2 MAP kinase phosphorylation and did not allow SR141716A to enhance the function of DAMGO.
Positive_regulation (Induction) of Gene_expression (expression) of CB1 associated with cannabinoid
1) Confidence 0.69 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.71
The CNR1 was covered by 10 SNPs located throughout the gene based on haplotype tagging (htSNP) and previous literature.
Positive_regulation (covered) of Gene_expression (covered) of CNR1
2) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19539700 Disease Relevance 1.18 Pain Relevance 1.20
Binding of endocannabinoids to the CB1 receptor results in activation of a G-protein leading to a reduction of neurotransmitter release, a process known as depolarization-induced suppression of inhibition (DSI) (Freund et al 2003; Diana and Mart 2004)
Positive_regulation (activation) of Gene_expression (results) of CB1 receptor associated with endocannabinoid and neurotransmitter
3) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 0.41 Pain Relevance 0.88
Binding of endocannabinoids to the CB1 receptor results in activation of a G-protein leading to a reduction of neurotransmitter release, a process known as depolarization-induced suppression of inhibition (DSI) (Freund et al 2003; Diana and Mart 2004)
Positive_regulation (leading) of Gene_expression (results) of CB1 receptor associated with endocannabinoid and neurotransmitter
4) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 0.41 Pain Relevance 0.94
Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors.
Positive_regulation (transfected) of Gene_expression (transfected) of CB1 in N18TG2 associated with neuroblastoma, cannabinoid and agonist
5) Confidence 0.49 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867259 Disease Relevance 0.10 Pain Relevance 0.21
Neutral antagonist and binding properties were confirmed in HEK-293 cells transfected with human CB1 or CB2 receptors.
Positive_regulation (transfected) of Gene_expression (transfected) of CB1 associated with antagonist
6) Confidence 0.47 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17959701 Disease Relevance 0.60 Pain Relevance 0.35
Thus, changes in cannabinoid receptor gene expression appear to be partially responsible for age-related loss of these receptors.
Positive_regulation (changes) of Gene_expression (expression) of cannabinoid receptor gene associated with cannabinoid receptor
7) Confidence 0.46 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1491804 Disease Relevance 0.09 Pain Relevance 0.26
After a 5-min pre-treatment, HU-210 (0.1 microM) significantly enhanced the effect of several concentrations of capsaicin on [Ca2+]i in HEK-293 cells over-expressing both rat CB1 and human VR1 (CB1-VR1-HEK cells), but not in cells over-expressing only human VR1 (VR1-HEK cells).
Positive_regulation (enhanced) of Neg (not) Gene_expression (expressing) of CB1 in HEK associated with qutenza
8) Confidence 0.43 Published 2003 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 12737320 Disease Relevance 0 Pain Relevance 0.55
Western blotting for measurement of cannabinoid receptor expression
Positive_regulation (measurement) of Gene_expression (expression) of cannabinoid receptor associated with cannabinoid receptor
9) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0 Pain Relevance 0.08
Reverse transcription-polymerase chain reaction for CB1 and CB2 receptors
Positive_regulation (reaction) of Gene_expression (receptors) of CB1
10) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0 Pain Relevance 0.09
In infants (<1 year) and pre-teens (5–11 years), CB1 expression was high, but in young children (1–2 years), adults (21–55 years), and older adults (>55 years) it was about 40% less (p <?
Positive_regulation (high) of Gene_expression (expression) of CB1 associated with cannabinoid receptor
11) Confidence 0.36 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.40 Pain Relevance 0.45
Needless to say, the step from astrocytoma cells in vitro to prostate cancer is large, and factors such as changes in receptor reserve (seen in normal tissues with a high CB1 expression, such as the hippocampus [56]) may also be of importance.
Positive_regulation (high) of Gene_expression (expression) of CB1 in hippocampus associated with anaplastic astrocytoma, prostate cancer and hippocampus
12) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.70 Pain Relevance 0.21
In contrast to the situation for Jurkat cells and T-lymphocytes, the expression of CB1 in LNCaP cells was not regulated by IL-4: the relative expression of CB1/GAPDH (% of untreated controls, means ± s.e.m., n?
Positive_regulation (by) of Gene_expression (expression) of CB1 in T-lymphocytes
13) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.37 Pain Relevance 0
In contrast to the situation for Jurkat cells and T-lymphocytes, the expression of CB1 in LNCaP cells was not regulated by IL-4: the relative expression of CB1/GAPDH (% of untreated controls, means ± s.e.m., n?
Positive_regulation (by) of Gene_expression (expression) of CB1 in T-lymphocytes
14) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.44 Pain Relevance 0
Additionally, it would be of interest to determine in cultured cells expressing high levels of CB1 receptors whether activation of these receptors results in an increased phosphorylation of EGFR, since this would provide an explanation for the low incidence of cases with a high CB1IR/low pEGFR-IR in the present study.

3.

Spec (whether) Positive_regulation (levels) of Spec (whether) Gene_expression (expressing) of CB1
15) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 0.62 Pain Relevance 0.09
CB1R is transiently increased, consistent with other reports related to pathways associated with pain sensation stimulated by colitis, and also consistent with data demonstrating increased CB1R expression in human IBD.


Positive_regulation (increased) of Gene_expression (expression) of CB1R associated with colitis, pain and inflammatory bowel disease
16) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.35 Pain Relevance 0.68
In addition, the new anandamides inhibit prostaglandin E1-stimulated adenylate cyclase activity in Chinese hamster ovary-K1 cells transfected with the cannabinoid receptor, as well as in N18TG2 mouse neuroblastoma cells that express the cannabinoid receptor naturally.
Positive_regulation (transfected) of Gene_expression (transfected) of cannabinoid receptor in N18TG2 associated with neuroblastoma and cannabinoid receptor
17) Confidence 0.04 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8749028 Disease Relevance 0.10 Pain Relevance 0.28
Moreover, an increase of cannabinoid receptor expression was also observed.
Positive_regulation (increase) of Gene_expression (expression) of cannabinoid receptor associated with cannabinoid receptor
18) Confidence 0.02 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 19931394 Disease Relevance 0.86 Pain Relevance 0.55
Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.
Spec (investigated) Positive_regulation (sepsis-induced) of Gene_expression (expression) of cannabinoid receptor in intestine associated with ileus, cannabinoid receptor and sepsis
19) Confidence 0.01 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.06 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox