INT10447

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Context Info
Confidence 0.40
First Reported 1983
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Srf) nucleolus (Srf) nucleus (Srf)
DNA binding (Srf) transcription factor binding (Srf) cytoplasm (Srf)
Anatomy Link Frequency
neurons 1
dorsal horn 1
Srf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
repetitive firing 3 100.00 Very High Very High Very High
Central grey 11 99.98 Very High Very High Very High
antiepileptic Drug 14 99.14 Very High Very High Very High
sodium channel 11 98.08 Very High Very High Very High
Dorsal horn 3 95.28 Very High Very High Very High
Spinal cord 2 92.52 High High
anticonvulsant 21 91.76 High High
Raphe magnus 14 90.60 High High
Dorsal horn neuron 6 90.16 High High
Action potential 1 82.84 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 99.98 Very High Very High Very High
Nociception 4 96.56 Very High Very High Very High
Epilepsy 22 58.64 Quite High
Tremor 1 45.92 Quite Low
Cluster Headache 1 44.56 Quite Low
Headache 3 43.72 Quite Low
Syndrome 3 43.32 Quite Low
Neuropathic Pain 2 42.92 Quite Low
Eating Disorder 4 42.20 Quite Low
Psychosis 10 41.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SDVAS produced a significant rightward, parallel shift in the stimulus response function (SRF) of class-2 neurons to noxious, graded heat stimuli ranging from 40 to 52 degrees C, while SDVAS produced a significant increase in the threshold and a significant reduction in the slope of the SRF of class-3 neurons.
Negative_regulation (reduction) of SRF in neurons
1) Confidence 0.40 Published 1992 Journal Pain Section Abstract Doc Link 1491862 Disease Relevance 0.07 Pain Relevance 0.44
However, the activity of TPM on sodium channels differs from that of other antiepileptic drugs (AEDs), in which a rapid limitation or complete block of SRF occurs.
Negative_regulation (block) of SRF associated with repetitive firing, sodium channel and antiepileptic drug
2) Confidence 0.15 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671954 Disease Relevance 0.12 Pain Relevance 0.83
Stimulation in the PAG decreased the slope of the stimulus-response function (SRF) without affecting unit thresholds of response, thus influencing the gain control of nociceptive transmission in the dorsal horn.
Negative_regulation (decreased) of SRF in dorsal horn associated with nociception, dorsal horn and central grey
3) Confidence 0.06 Published 1983 Journal J. Neurophysiol. Section Abstract Doc Link 6663336 Disease Relevance 0.76 Pain Relevance 0.71

General Comments

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