INT104474

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 3.10
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
corneas 5
tear 3
corneal epithelium 2
endothelial cells 1
cartilage 1
Mmp8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 99.84 Very High Very High Very High
metalloproteinase 317 98.80 Very High Very High Very High
Osteoarthritis 4 87.08 High High
Inflammation 49 80.80 Quite High
alcohol 9 80.08 Quite High
cINOD 6 75.36 Quite High
agonist 1 73.04 Quite High
cytokine 15 70.12 Quite High
nMDA receptor 42 65.92 Quite High
corticosteroid 1 51.84 Quite High
Disease Link Frequency Relevance Heat
Pain 3 99.84 Very High Very High Very High
Disease 26 95.00 High High
Wound Healing 78 90.36 High High
Osteoarthritis 4 87.08 High High
Pathologic Processes 9 82.92 Quite High
INFLAMMATION 68 80.80 Quite High
Corneal Perforation 27 79.76 Quite High
Stress 30 76.28 Quite High
Periodontal Disease 48 72.84 Quite High
Keratitis 18 68.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The corneas were excised and processed for immunohistochemical staining, Western blot assay, and zymography studies to determine the localization of the production of the following matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-8, and MMP-9.
Spec (determine) Gene_expression (production) of MMP-8 in corneas
1) Confidence 0.71 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Matrix metalloproteinase-1, MMP-8, and MMP-2 were detected in rat corneas at 48 hours in the debrided and intact epithelium groups treated with NSAID eyedrops.
Gene_expression (detected) of MMP-8 in corneas
2) Confidence 0.71 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.05 Pain Relevance 0
The MMP-1 and MMP-8 expression levels were higher in intact corneas in the diclofenac sodium groups than in the ketorolac and artificial tears groups.
Gene_expression (expression) of MMP-8 in tears
3) Confidence 0.71 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
CONCLUSION: This study provides preliminary evidence that topical application of some NSAIDs can induce the early expression of MMP-1, MMP-2, and MMP-8 in the cornea, suggesting that MMPs play a role in the corneal cytotoxicity of certain NSAIDs.


Gene_expression (expression) of MMP-8 in cornea
4) Confidence 0.62 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
The levels of MMP-1 and MMP-8 in the cornea-conditioned culture medium were assessed by Western blot.
Gene_expression (levels) of MMP-8 in cornea
5) Confidence 0.53 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0 Pain Relevance 0.03
MMP-1, MMP-2, MMP-8 and MMP-9 expression were detected at 48 hrs in undebrided corneal epithelium groups treated with the topical fluoroquinolones.
Gene_expression (expression) of MMP-8 in corneal epithelium
6) Confidence 0.41 Published 2003 Journal BMC Ophthalmol Section Abstract Doc Link PMC239861 Disease Relevance 0.13 Pain Relevance 0.33
These studies also disclosed that the application of the present ophthalmic fluoroquinolone solutions (Ciloxan, Ocuflox and Quixin) increases MMP-1, MMP-8 (immunoblots, figure 2) and MMP-2, MMP-9 (zymography, figure 3) expression in both intact and wounded corneas although the levels of expression may be slightly different among various groups.
Gene_expression (expression) of MMP-8 in corneas
7) Confidence 0.41 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.07 Pain Relevance 0.12
We focused on two specific groups: collagenases and gelatinases; evaluating the expression of interstitial collagenase (MMP-1) and PMN collagenase (MMP-8), both of which can be secreted by corneal cells and are able to cleave corneal stromal collagens.
Gene_expression (expression) of MMP-8
8) Confidence 0.41 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.34 Pain Relevance 0.17
Our study provides preliminary evidence that topical application of fluoroquinolone drugs can induce the expression of MMP-1, MMP-2, MMP-8 and MMP-9 in the undebrided corneal epithelium compared to artificial tear eye drops.



Gene_expression (expression) of MMP-8 in tear
9) Confidence 0.41 Published 2003 Journal BMC Ophthalmol Section Abstract Doc Link PMC239861 Disease Relevance 0.09 Pain Relevance 0.23
Furthermore, the results of our study clearly demonstrate that the commercial fluoroquinolone ophthalmic agents tested stimulate expression of corneal collagenases (MMP-1 and MMP-8) and gelatinases (MMP-2 and MMP-9) in normal eyes compared to a negative expression of MMPs in the artificial tear group.
Gene_expression (expression) of MMP-8 in tear associated with metalloproteinase
10) Confidence 0.36 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.36 Pain Relevance 0.23
These findings identify a novel source of MMP-8 expression at the corneal epithelial cells as a non-PMN cellular source of this collagenase.
Gene_expression (expression) of MMP-8 in corneal epithelial cells
11) Confidence 0.36 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.06 Pain Relevance 0.15
In previous studies, we also observed MMP-8 expression at the level of the corneal epithelium associated with ulcerative keratolysis.
Gene_expression (expression) of MMP-8 in corneal epithelium
12) Confidence 0.36 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.06 Pain Relevance 0.16
Additional studies are required to confirm the exact cellular origin of MMP-8 expressed in corneal tissue, although it is now recognized that cell types other than PMNs can express this collagenase.
Gene_expression (expressed) of MMP-8
13) Confidence 0.36 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.26 Pain Relevance 0.24
Inhibition of synthesis of MMP-8 and MMP-9 by endothelial cells in response to doxycycline and to a lesser extent by the chemically modified tetracyclines (CMTs) has been demonstrated at the mRNA level [56].
Gene_expression (synthesis) of MMP-8 in endothelial cells
14) Confidence 0.07 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.95 Pain Relevance 0.27
The presence of MMP-8 or both MMP-2 and MMP-9-inhibitors during NMDA stimulation did not prevent the loss of extracellular NR1 epitopes (data not shown).
Gene_expression (presence) of MMP-8
15) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.26
During treatment with nimesulide, in addition to clinical improvement and less pain, serum levels of MMP-3, MMP-8 and COMP fell indicating a beneficial effect on cartilage catabolism.
Gene_expression (levels) of MMP-8 in cartilage associated with pain
16) Confidence 0.06 Published 2002 Journal Int J Clin Pract Suppl Section Abstract Doc Link 12166616 Disease Relevance 0.66 Pain Relevance 0.58

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