INT104476

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.75
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
cartilage 1
extracellular matrix 1
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 61 100.00 Very High Very High Very High
Osteoarthritis 4 99.84 Very High Very High Very High
Pain 6 99.52 Very High Very High Very High
Arthritis 111 97.64 Very High Very High Very High
rheumatoid arthritis 55 95.92 Very High Very High Very High
cytokine 43 95.72 Very High Very High Very High
cINOD 3 91.84 High High
Inflammation 52 90.28 High High
fibrosis 26 83.48 Quite High
Glutamate 1 77.60 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 4 99.84 Very High Very High Very High
Arthritis 115 97.64 Very High Very High Very High
Disease 70 97.52 Very High Very High Very High
Systemic Sclerosis 67 97.08 Very High Very High Very High
Appetite Loss 90 96.80 Very High Very High Very High
Rheumatoid Arthritis 55 95.92 Very High Very High Very High
INFLAMMATION 58 91.12 High High
Congenital Anomalies 14 85.36 High High
Fibrosis 24 83.48 Quite High
Immunization 1 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that selectively degrade the components of various extracellular matrixes.
Protein_catabolism (degrade) of metalloproteinases associated with metalloproteinase
1) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.50 Pain Relevance 0.28
Based on the evidence from laboratory and clinical trials, it is evident that EPA is a promising agent that may attenuate protein degradation by targeting the proteasomes, and have enough evidence to warrant use in clinical trials to examine its efficacy for the treatment of CC.
Protein_catabolism (degradation) of EPA associated with appetite loss
2) Confidence 0.39 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 1.33 Pain Relevance 0.05
Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade extracellular matrix components.
Protein_catabolism (degrade) of metalloproteinases in extracellular matrix associated with metalloproteinase
3) Confidence 0.12 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14741353 Disease Relevance 0.45 Pain Relevance 0.44
Matrix metalloproteinases (MMPs) degrade extracellular matrix components and have been demonstrated to contribute to cartilage degradation in RA.
Protein_catabolism (degrade) of metalloproteinases in cartilage associated with rheumatoid arthritis and metalloproteinase
4) Confidence 0.10 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.55 Pain Relevance 0.80
Degrading Zinc Metalloproteinases
Protein_catabolism (Degrading) of Metalloproteinases associated with metalloproteinase
5) Confidence 0.02 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.31 Pain Relevance 0.26
Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study.
Protein_catabolism (degradation) of metalloproteinases associated with pain, metalloproteinase and osteoarthritis
6) Confidence 0.00 Published 2002 Journal Int J Clin Pract Suppl Section Title Doc Link 12166616 Disease Relevance 0.61 Pain Relevance 0.79

General Comments

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