INT104478

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.56
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
transcription factor binding (Mapk9) cytoplasm (Mapk9)
Anatomy Link Frequency
neuronal 1
Mapk9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 26 99.12 Very High Very High Very High
tolerance 7 97.64 Very High Very High Very High
cytokine 18 95.08 Very High Very High Very High
Inflammation 24 92.24 High High
diabetic neuropathy 47 87.20 High High
anesthesia 2 84.80 Quite High
unmyelinated 2 84.08 Quite High
Pyramidal cell 2 80.08 Quite High
Analgesic 1 72.48 Quite High
Nerve growth factor 8 58.08 Quite High
Disease Link Frequency Relevance Heat
Stress 73 100.00 Very High Very High Very High
Apoptosis 272 99.68 Very High Very High Very High
Diabetes Mellitus 69 99.60 Very High Very High Very High
Hemorrhage 26 99.12 Very High Very High Very High
Disease 258 98.16 Very High Very High Very High
Toxicity 30 96.20 Very High Very High Very High
Carcinoma 2 96.04 Very High Very High Very High
Sepsis 2 92.36 High High
Aging 10 92.28 High High
Necrosis 7 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, activation of both p44/42 and SAPK/JNK in response to LPS, was significantly lower in the SLH rats when compared to shams.
Positive_regulation (activation) of SAPK associated with cva
1) Confidence 0.67 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 1.04 Pain Relevance 0.74
Moreover, STME inhibited inducible nitric oxide synthase expression and blunted nitrite release and inhibited both extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation in lipopolysaccharide-stimulated MPhis.
Positive_regulation (activation) of c-Jun N-terminal kinase
2) Confidence 0.57 Published 2008 Journal Pharmacology Section Abstract Doc Link 18818510 Disease Relevance 0.40 Pain Relevance 0.23
The purpose of this study was to explore whether changes in p44/42 and SAPK/JNK MAP kinase activity also occur after the induction of tolerance by SLH.
Spec (whether) Positive_regulation (changes) of SAPK associated with tolerance and cva
3) Confidence 0.49 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 0.73 Pain Relevance 0.55
upregulation of phosphorylating stress kinases like SAPK and GSK-3?
Positive_regulation (upregulation) of SAPK associated with stress
4) Confidence 0.33 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.70 Pain Relevance 0.19
Furthermore, cell cycle re-entry might also be triggered by oxidative stress through activation of the stress-activated protein kinases JNK-SAPK and p38-SAPK2, which control stress responses in AD [176], suggesting a possible link between the occurrence of cell cycle reentry and increased oxidative stress and neuronal vulnerability in aging.
Positive_regulation (activation) of SAPK in neuronal associated with stress, aging and disease
5) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.27 Pain Relevance 0.04
-induced apoptosis is mediated by activation of the Stress-activated protein kinases (SAPK) p38 Mitogen Activated Protein Kinase (p38MAPK) and JNK, followed by activation of both NF-kB and p53 [171,174,175].
Positive_regulation (activation) of SAPK associated with stress and apoptosis
6) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.42 Pain Relevance 0.06

General Comments

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