INT10448

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Srf) nucleolus (Srf) nucleus (Srf)
DNA binding (Srf) transcription factor binding (Srf) cytoplasm (Srf)
Anatomy Link Frequency
MRFS 1
neurons 1
stage 5 1
Srf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 12 87.76 High High
Dorsal horn neuron 7 87.76 High High
tail-flick 6 75.04 Quite High
lidocaine 4 75.00 Quite High
midbrain 2 75.00 Quite High
Locus ceruleus 1 71.24 Quite High
c fibre 1 59.64 Quite High
vagus nerve 1 54.16 Quite High
Central grey 1 46.32 Quite Low
medulla 1 28.36 Quite Low
Disease Link Frequency Relevance Heat
Retinopathy 23 99.12 Very High Very High Very High
Retina Disease 4 96.48 Very High Very High Very High
Disease 7 78.40 Quite High
Nociception 4 75.00 Quite High
Hypoxia 5 73.40 Quite High
Uveitis 1 62.00 Quite High
Glaucoma 4 52.80 Quite High
Urological Neuroanatomy 1 46.32 Quite Low
Paralysis 1 25.00 Low Low
Birth Weight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SDVAS produced a significant rightward, parallel shift in the stimulus response function (SRF) of class-2 neurons to noxious, graded heat stimuli ranging from 40 to 52 degrees C, while SDVAS produced a significant increase in the threshold and a significant reduction in the slope of the SRF of class-3 neurons.
Positive_regulation (produced) of SRF in neurons
1) Confidence 0.47 Published 1992 Journal Pain Section Abstract Doc Link 1491862 Disease Relevance 0.13 Pain Relevance 0.54
MRFS shifted this stimulus response function (SRF) to the right, raising significantly the threshold of response a mean 2.2 degrees C to noxious heating of the skin without significantly affecting the slope of the SRF.
Positive_regulation (shifted) of SRF in MRFS
2) Confidence 0.19 Published 1983 Journal J. Neurophysiol. Section Abstract Doc Link 6663337 Disease Relevance 0.07 Pain Relevance 0.49
The results of this study conf irm the existence of elevated VEGF levels in vitreous, aqueous and SRF in eyes with stage 5 ROP, which remain high despite the significant damage to the intraocular structures.
Positive_regulation (elevated) of SRF in stage 5 associated with retinopathy
3) Confidence 0.07 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2938272 Disease Relevance 0.69 Pain Relevance 0

General Comments

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